Causes of microcytic anaemia and evaluation of conventional laboratory parameters in the differentiation of erythrocytic microcytosis in blood donors candidates

Carlos, Aline Menezes; Souza, Bruna Maria Bereta de; Souza, Renata Andréia Volpe de; Resende, Gláucia Aparecida Domingos; Pereira, Gilberto de Araújo; Moraes-Souza, Hélio

doi:10.1080/10245332.2018.1446703

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…Majority of the children had microcytic anaemia (59.3%) that occurred abundantly in males (64.6%), those undernourished (64.3%) especially the stunted (66.2%) and those whose parents had primary level of education (63.0%). Microcytic anaemia result from defective synthesis of haemoglobin causing a reduction in its mean corpuscular volume and the most common causes include iron deficiency anaemia, anaemia of chronic disease, α- thalassemias and sideroblastic anaemia [ 34 – 36 ]. The high proportion of microcytic anaemia which is probably linked to the occurrence of microcytosis (70.9%) suggests iron deficiency is the main cause of anaemia in the population.…”

Section: Discussionmentioning

confidence: 99%

Burden of moderate to severe anaemia and severe stunting in children < 3 years in conflict-hit Mount Cameroon: a community based descriptive cross-sectional study

et al. 2020

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Background: Armed conflict is a significant social determinant of child health with nuanced effects. There is a dearth of knowledge on the public health issues facing vulnerable populations in conflict-stricken areas. The objective was to determine the prevalence and determinants of moderate to severe anaemia (MdSA) and severe stunting (SS) in children ≤3 years in conflict-hit Dibanda, Ekona and Muea in the Mount Cameroon area. Methods: Haematological parameters were obtained using an automated haematology analyser while undernutrition indices standard deviation (SD) scores (z-scores), were computed based on the WHO growth reference curves for 649 children in a community based cross-sectional study in 2018. Binomial logistic regression models were used to evaluate the determinants of MdSA and SS against a set of predictor variables. Results: Anaemia was prevalent in 84.0% (545) of the children with a majority having microcytic anaemia (59.3%). The prevalence of MdSA was 56.1% (364). Educational level of parents/caregiver (P < 0.001) and site (P = 0.043) had a significant negative effect on the occurrence of MdSA. Stunting, underweight and wasting occurred in 31.3, 13.1 and 6.3% of the children, respectively. Overall, SS was prevalent in 17.1% (111) of the children. The age groups (0.1-1.0 year, P = 0.042 and 1.1-2.0 years, P = 0.008), educational levels (no formal education, P < 0.001 and primary education P = 0.028) and SS (P = 0.035) were significant determinants of MdSA while MdSA (P = 0.035) was the only significant determinant of SS. On the contrary, age group 0.1-1 year (OR = 0.56, P = 0.043) and site (Dibanda, OR = 0.29, P = 0.001) demonstrated a significant protective effect against SS. Conclusions: Moderate to severe anaemia, severe stunting and wasting especially in children not breastfed at all are public health challenges in the conflict-hit area. There is a need for targeted intervention to control anaemia as well as increased awareness of exclusive breast feeding in conflict-hit areas to limit the burden of wasting and stunting.

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Section: Discussionmentioning

confidence: 99%

Burden of moderate to severe anaemia and severe stunting in children < 3 years in conflict-hit Mount Cameroon: a community based descriptive cross-sectional study

et al. 2020

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show abstract

“…Majority of the children had microcytic anaemia (59.3%) that occurred abundantly in males (64.6%), those undernourished (64.3%) especially the stunted (66.2%) and those whose parents had primary level of education (63.0%). Microcytic anaemia result from defective synthesis of haemoglobin causing a reduction in its MCV and the most common causes include iron deficiency anaemia, anaemia of chronic disease, α-thalassemias and sideroblastic anaemia [34,35,36]. The high proportion of microcytic anaemia which is probably linked to the occurrence of microcytosis (70.9%) suggests iron deficiency is the main cause of anaemia in the population.…”

Section: Discussionmentioning

confidence: 99%

Burden of moderate to severe anaemia and severe stunting in children ≤ 3 years in conflict hit Mount Cameroon: a community based descriptive cross-sectional study

Sumbele¹

2020

Preprint

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Background: Armed conflict is a significant social determinant of child health with nuanced effects. There is a dearth of knowledge on the public health issues facing vulnerable populations in conflict-stricken areas. The objective was to determine the prevalence and determinants of moderate to severe anaemia (MdSA) and severe stunting (SS) in children ≤3 years in conflict hit Dibanda, Ekona and Muea in the Mount Cameroon area.Methods: Haematological parameters were obtained using an automated haematology analyser while, undernutrition indices standard deviation (SD) scores (Z scores) were computed based on the WHO growth reference curves for 649 children in a community based cross-sectional study in 2018. Binomial logistic regression models were used to evaluate the determinants of MdSA and SS against a set of predictor variables.Results: Anaemia was prevalent in 84.0% (545) of the children with a majority having microcytic anaemia (59.3%). The prevalence of MdSA was 56.1% (364). Educational level of parents/caregiver (P < 0.001) and site (P = 0.043) had a significant negative effect on the occurrence of MdSA. Stunting, underweight and wasting occurred in 31.3%, 13.1% and 6.3% of the children respectively. Overall, SS was prevalent in 17.1% (111) of the children. The age group (0.1–1.0 year, P = 0.042 and 1.1–2.0 years, P = 0.008), educational level (No formal education, P < 0.001 and primary education P = 0.028) and SS (P = 0.035) were significant determinants of MdSA while MdSA (P = 0.035) was the only significant determinant of SS. On the contrary, age group 0.1-1 year (OR = 0.56, P = 0.043) and site (Dibanda, OR = 0.29, P = 0.001) demonstrated a significant protective effect against SS.Conclusions: Moderate to severe anaemia, severe stunting and wasting especially in children not breastfed at all are public health challenges in the conflict hit area. There is a need for targeted intervention to control anaemia as well as increase awareness of exclusive breast feeding in conflict hit areas to limit the burden of wasting and stunting.

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“…22,23 Esta pérdida pocas veces se recupera puesto que para mitigar lo que supone una sola sesión de donación los enterocitos encargados de la absorción del hierro en la dieta, tendrían que absorberlo todo y aun así tardarían entre15 y 20 días para restituir los niveles normales, lo que puede conllevar a una anemia por deficiencia de hierro en los donadores frecuentes. 3,24 Se sabe que los niveles de hemoglobina y hematocrito no sirven para la detección de depleción de hierro en pacientes con hemoglobina en niveles relativamente normales, lo que sugiere que estos casos pueden tener una deficiencia de hierro subclínica. 25,26 Además se ha observado en algunos estudios que 42% de los pacientes presentan bajos niveles de ferritina, cifra que aumenta con la frecuencia de las donaciones.…”

Section: Deficiencia De Hierrounclassified

La Donación de Sangre

Ariño

Martínez

2021

Repert. Med. Cir.

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La donación de sangre es un procedimiento muy común en medicina, por eso tiene relevancia el estudio de las complicaciones frecuentes en los donantes y en especial las asociadas con la ferropenia. El procedimiento reporta beneficios tanto por la utilidad futura del producto como por los efectos favorables para la salud del donante; sin embargo, se han descrito complicaciones recurrentes derivadas tanto de la extracción de sangre total como de sus componentes por separado. En este artículo de revisión se encuentra la información relacionada con los factores de riesgo asociados con esta práctica y las principales complicaciones que pueden aparecer como es la depleción de hierro, con el fin de ilustrar al lector sobre los factores predisponentes en donantes iniciales y habituales. Se concluye que las reacciones más frecuentes son las vasovagales y algunas otras que pueden conllevar a síntomas indeseados, pero es la disminución de los niveles de hierro una de las complicaciones más alarmantes. Hay evidencia de factores como sexo, edad, nivel socioeconómico, dieta y tipo de sangre que favorecen la probabilidad de desarrollar complicaciones por deficiencia de hierro en los donantes.

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Causes of microcytic anaemia and evaluation of conventional laboratory parameters in the differentiation of erythrocytic microcytosis in blood donors candidates

Cited by 7 publications

References 25 publications

Burden of moderate to severe anaemia and severe stunting in children < 3 years in conflict-hit Mount Cameroon: a community based descriptive cross-sectional study

Burden of moderate to severe anaemia and severe stunting in children < 3 years in conflict-hit Mount Cameroon: a community based descriptive cross-sectional study

Burden of moderate to severe anaemia and severe stunting in children ≤ 3 years in conflict hit Mount Cameroon: a community based descriptive cross-sectional study

La Donación de Sangre

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