Изучение популяционно-генетической структуры североосетинских кумыков проводится в рамках генетико-эпидемиологического обследования населения республики Северная Осетия-Алания. Кумыки компактно проживают в Моздокском районе и составляют 18% населения района. В данной работе использованы небиологические источники информации - 6303 брачные записи (тотальная выборка) и 50 демографических анкет, полученных в ходе опроса женщин пострепродуктивного возраста. Параметры изоляции расстоянием Малеко: Nе=4220, σ=35,6, а=0,00067, b=0,0277. Индекс территориальной эндогамии 0,86. Этническая брачная ассортативность 3,3. Интенсивность метисации 17,6%. Эффективная плодовитость 2,94±0,17. Тотальный индекс Кроу составил 0,214, а его компоненты Im=0,048, If=0,159.
The study of the genetic structure of the North Ossetian Kumyks is carried out as part of a genetic and epidemiological survey of the population of the Republic of North Ossetia-Alania. Kumyks compactly live in Mozdoksky district and present 18% of district population. Based on the marriage records for 1990-2000, the main population genetic parameters of the North Ossetian Kumyks were determined. Malekot’s parameters of isolation are Ne=4220, σ=35.6, a=0.00067, b=0.0277. The territorial endogamy index is 0.86. Ethnic marital assortativity is 3.3. The intensity of mestization is 17.6%. Effective fertility is 2.94±0.17. The total Crow index is 0.214, and its components Im=0.048, If=0.159.
Glyphosate is one of the most widely used herbicides in the world. In recent years, there have been concerns about the possible mutagenicity and carcinogenicity of this pesticide. In this connection, the study of genotoxic and carcinogenic properties of glyphosate and glyphosate-containing preparations has been resumed in a number of countries. In this study, the induction of micronucleation formation in vivo in polychromatophilic erythrocytes of bone marrow of CD-1 mice was assessed by the action of three different technical glyphosate products entering the Russian Federation. It was found that the tested samples of technical products showed different cytogenetic activity, while only one of them caused a statistically significant, dose-dependent increase in the frequency of induction of micronuclei compared to the negative control. The analysis of the composition of the studied product samples showed that the cytogenetic activity may depend on the content of potentially mutagenic impurities, in particular formaldehyde. The obtained data are additional grounds for lowering the upper limit of formaldehyde content in technical products of glyphosate and also indicate the need to assess the genotoxic activity of analog pesticides entering the market of plant protection products.
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