Objective: to study the state of cytokine status in children with acute and chronic urticaria.Materials and methods: 264 children of both sexes aged from 6 to 16 years with different variants of urticaria were examined. Clinical research methods included analysis of anamnestic data, objective examination of the child to determine the severity of urticaria. Immunological research methods included determination of IL-4, IL-6, IL-17, and IFN-γ levels by the method of enzyme immunoassay of blood serum.Results: cytokine profile analysis revealed hyperproduction of IL-17, γ-IFN with reduced IL-4 synthesis in children with acute urticaria. In children with chronic urticaria, IL-6 hyperproduction is noted against the background of a significant decrease in IL-4 synthesis.Conclusion: there was a significant relationship between the development of severe acute urticaria and the levels of proinflammatory cytokines IL-6, IL-17, and between the formation of chronic urticaria and the level of IL-6.
Литературный обзор посвящен влиянию витамина D на иммунный ответ организма. Как показывают исследования, витамин D способен ингибиро-вать синтез провоспалительных цитокинов и, как следствие, играть важную роль в формировании иммунной толерантности, что важно при ин-фекционных, аутоиммунных заболеваниях и у пациентов после трансплантации органов. Витамин D может применяться как в качестве профилак-тики, так и в лечебных целях при инфекционных заболеваниях, в онкогематологии, аллергологии, гастроэнтерологии, а также способен влиять на внутриутробное развитие плода и иммунный ответ новорожденного, снижая риск развития патологии беременности, преждевременных родов и патологии плаценты, а также уменьшая частоту, степень тяжести и риск неблагоприятного исхода у новорожденных с врожденной и приобретен-ной инфекционной патологией. В постнатальном периоде нормальная обеспеченность витамином D не только снижает частоту, но и предотвра-щает формирование тяжелых форм аутоиммунных, аллергических заболеваний у детей и подростков. Ключевые слова: витамин D, иммунитет, кальцитриол, плацента, инфекционные заболевания, аутоиммунные болезни. Для цитирования: Захарова И.Н., Мальцев С.В., Заплатников А.Л. и др. Влияние витамина D на иммунный ответ организма. Педиатрия. Consilium Medicum. 2020; 2: 29–37. DOI: 10.26442/26586630.2020.2.200238
The aim of the research is to assess the possibility of using the energy-dispersive X-ray fluorescence method directly at the stoping operation site. To meet this objective, a hand-held X-ray fluorescence spectrometer of the expert class of the NITON XL2 brand was selected. This will solve the problem of developing an express method for assessing the explosive and fire-hazardous properties of sulfur-containing or pyrite-containing ore. The development of the method is dictated by the need for operational control of the dust explosion hazard of sulfur-containing rocks and the assessment of their tendency to spontaneous combustion and also the possibility of making amendments to the development process of complex heterogeneous host rocks. Visual and optical control methods were used as an auxiliary method. In the process of developing the express method, both express analyses were carried out directly at the face bottom, and monolithic large-sized pieces of mined rock mass and also additional laboratory studies of previously studied samples of these rocks dispersed to a size of less than 100 microns were performed. The obtained results allowed to draw a number of conclusions about the expediency of using the X-ray fluorescence express method and suggest ways to use it directly in the stoping face.
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