Reduced Bone Mineral Density in Children and Adolescents: Causes, Incidence and Treatment

Мальцев, С. В.; Мансурова, Г. Ш.

doi:10.15690/vsp.v14i5.1442

Cited by 11 publications

(3 citation statements)

References 6 publications

(13 reference statements)

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“…Так, к примеру, в позвонках самый интенсивный рост значений фракции жира наблюдается в возрасте от 0 до 8-10 лет [21]. Исходя из наблюдений российских ученых [3], дети от 10 лет подвержены максимальному риску снижения минеральной плотности, что определяет наибольший интерес к этой группе в плане дальнейших исследований.…”

Section: Discussionunclassified

“…По статистике, остеопороз регистрируют у каждой третьей женщины и каждого четвертого мужчины в возрасте 50 лет и старше [2]. Частота остеопении в периоды интенсивного роста детского организма достигает 40-55% [3]. Низкие значения МПКТ в детском возрасте существенно увеличивают вероятность раннего заболевания остеопорозом, так как пик формирования костной массы приходится на возраст 20-25 лет, а затем прочность костей постепенно снижается.…”

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Proton magnetic resonance spectroscopy as an alternative method for quantitative assessment of mineral bone density

Ivantsova

Menshchikov

Polyakova

et al. 2021

Almanac of Clinical Medicine

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Aims: 1) To evaluate an association between the fat fraction (FF) and bone mineral density (BMD) measured by localized proton magnetic resonance spectroscopy (1H-MRS) and quantitative computed tomography (QCT) densitometry, respectively, in healthy vertebrae of children after a compression fracture; 2) To compare the FF and BMD values with the severity of the compression vertebrae fractures.Materials and methods: Twenty (20) patients (aged 11.1±2.1 years) with a trauma-induced compression vertebral fractures participated in the study. The BMD of L3, L4 vertebrae (mg/cm3) was measured in by QCT (Philips Brilliance 16). FF in the same area was measured from 1H-MR-spectra (STEAM, echo time (TE)=12.8 ms, repetition time (TR)=3000 ms, voxel size=20×15×10 mm) using Philips Achieva TX 3.0T MRI scanner.Results: Correlation analysis revealed a significant inverse linear correlation (r=-0.55, p=0.0004) between FF and BMD of L3 и L4 vertebrae. In addition, in the patients with severe compression vertebral fracture (more than 2 fractured vertebrae) there was a significant increase in FF values and a BMD decrease, compared to the values in the patients with mild fractures (1–2 fractured vertebrae).Conclusion: The correlation suggests that the increase of FF in the bone marrow and the decrease of BMD in children go in parallel. Therefore, 1H-MRS could be an alternative to QCT and dual-energy X-ray absorptiometry. The absence of radiation load allows for recommendation to use 1Н-MRS for screening and follow-up, as well as for the control of BMD.

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Section: Discussionunclassified

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Proton magnetic resonance spectroscopy as an alternative method for quantitative assessment of mineral bone density

Ivantsova

Menshchikov

Polyakova

et al. 2021

Almanac of Clinical Medicine

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“…Впроцессеразвитияребенкаопорныеструктуры скелетапроходятпоследовательныеэтапыформирования,вовремякоторыхпроисходятизменениямикроструктуры и степени минерализации костного матрикса [22]. В результате формируется пиковая костнаямасса,котораяопределяетпрочностьиустойчивостьскелетавпоследующиегодыжизни.Ееснижениеявляетсяпрогностическимфакторомразвития остеопороза, нарушений осанки, переломов в дальнейшейжизни [23][24][25].…”

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Impact of malignant neoplasms on musculoskeletal system in children (literature review)

Тихонова¹,

Крутикова²,

Karelin³

et al. 2019

Onkogematologiâ

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Because of the successful implementation of modern treatment technologies at any stage of therapy of children with oncohematological diseases, their overall and disease-free survival has increased significantly. According to recent observations, 80 % of children after the completion of a special antitumor treatment continue to have changes of different organs. Almost all patients are at risk for late complications from the musculoskeletal system but little attention is paid to this issue. Evaluation of long-term complications from the musculoskeletal system and mineral metabolism in patients, development of their complex rehabilitation and prevention is an actual problem of pediatric oncology and hematology. This review summarizes data on long-term complications from the musculoskeletal system after special therapy. The necessity of diagnostics approaches harmonization and correction of not only the most common complications, but also little studied conditions, such as reduction of bone mineralization, is shown. It is noted that multidisciplinary rehabilitation treatment of children in remission can not only correct the consequences of the underlying disease, concomitant pathology and the consequences of special therapy but also reduce the disability of children.

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Methods of prevention of calcium deficiency in pediatric practice

Taranushenko¹,

NG²,

TV³

2022

Arch Prev Med

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It is known that the prevention of deficiency conditions in children is one of the most urgent tasks of preventive pediatrics. The importance of timely recommendations for optimizing the replenishment of microelements and vitamins is undeniable, and understanding the importance of using calcium and vitamin D supplements significantly reduces the risk of adverse health effects in childhood and later life.

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Reduced Bone Mineral Density in Children and Adolescents: Causes, Incidence and Treatment

Cited by 11 publications

References 6 publications

Proton magnetic resonance spectroscopy as an alternative method for quantitative assessment of mineral bone density

Proton magnetic resonance spectroscopy as an alternative method for quantitative assessment of mineral bone density

Impact of malignant neoplasms on musculoskeletal system in children (literature review)

Methods of prevention of calcium deficiency in pediatric practice

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