Cytokine status disorders in children with urticaria

Мальцев, С. В.; Сизякина, Л. П.; Лебеденко, А. А.; Pampura, A N

doi:10.21886/2219-8075-2020-11-4-51-57

Cited by 3 publications

(3 citation statements)

References 3 publications

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Section: Methodsmentioning

confidence: 99%

“…The diagnostic criteria for acute urticaria included: sudden onset; immediate pruritus with the appearance of irregularly shaped wheals of varying colors, resulting in an uneven, orange-peel-like skin texture; transient skin edema that resolves swiftly, with wheals transitioning to erythema before fading, while new wheals continue to emerge; and a disease duration not exceeding 6 weeks. [10][11][12] Eligibility criteria for participants were: conformity to the acute urticaria diagnostic criteria; provision of informed consent and willingness to participate in the study and undergo follow-up; age between 18 and 65 years; absence of long-acting glucocorticoid or steroid use within 2 weeks prior to enrollment, and no antihistamine or corticosteroid use within 1 week prior to enrollment; normal results in routine blood, stool, and urine tests, and normal liver and kidney function.…”

Section: General Informationmentioning

confidence: 99%

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CNP model intervention effect on acute urticaria patients’ psychological status, compliance, and life quality

Yang,

Ma,

Wei

et al. 2024

Medicine

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This study aimed to evaluate the impact of the clinical nursing pathway (CNP) on the psychological state, treatment adherence, and quality of life in patients with acute urticaria. A total of 240 patients diagnosed with acute urticaria at a tertiary hospital in Shandong Province were retrospectively assigned to either a control group, receiving standard care, or an intervention group, receiving care according to the CNP model. The primary outcomes assessed were levels of anxiety, depression, quality of life, and patient compliance. Statistical analyses were employed to evaluate the outcomes. Following the intervention, significant differences were observed in the anxiety and depression scores (P < .001), with the intervention group demonstrating lower levels of both. The control group’s psychological state exhibited significant variance pre- and post-intervention (P < .001), alongside notably reduced overall compliance (P < .01). Post-intervention, patients in the intervention group showed enhanced treatment compliance, with a rapid increase within the first hour and a stable ascent over the following 10 hours, albeit with a marginally greater increase in the CNP group. Beyond 10 hours, the CNP group’s compliance gradually declined, with a slight uptick in noncompliance rates. By 14 hours, the control group’s overall compliance began to wane, with a sharp decline in full compliance and a rapid rise in noncompliance rates observed after 19 hours. At the 20-hour mark, the control group’s noncompliance rate surpassed both the partial and full compliance rates. Conversely, post-20 hours, the CNP group maintained higher rates of full and partial compliance, with a lower noncompliance rate. No significant changes were noted in the control group’s physiological or mental state, except in the domains of self-care and social ability, where notable differences were absent pre- and post-intervention. In contrast, the CNP group showed significant improvements in physiological and mental states, self-care, and social abilities post-intervention (P < .001), with noticeable differences in these domains evident 6 hours into the treatment (P < .01), leading to an enhanced quality of life. The CNP-based clinical nursing model intervention significantly benefits patients with acute urticaria by alleviating anxiety and depression, enhancing treatment adherence, and improving overall quality of life.

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Section: Methodsmentioning

confidence: 99%

Section: General Informationmentioning

confidence: 99%

CNP model intervention effect on acute urticaria patients’ psychological status, compliance, and life quality

Yang,

Ma,

Wei

et al. 2024

Medicine

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“…Активация и стимуляция Th2 приводит к усилению продукции IL-4, IL-5, IL-9, IL-13 -цитокинов, принимающих участие в регуляции синтеза IgE [3]. Однако если роли некоторых интерлейкинов (IL-4, IL-5, IL-13) посвящено достаточное количество публикаций [4][5][6][7], то сведений о значении IL-9 в развитии данной патологии в доступной литературе практически нет.…”

Section:  введениеunclassified

Features of Cytokine Status in Children with Acute Urticaria

Султанова¹,

Шихаммадова²

2023

Педиатрия. Восточная Европа

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Введение. Исследование цитокинового профиля пациентов, страдающих крапивницей, является определяющим в понимании механизмов развития различных форм заболевания. Цель. Определение показателей уровня цитокинов (IL-9, IL-17, TNFβ) у детей с острой крапивницей. Материалы и методы. Обследовано 80 детей обоего пола, поступивших под наблюдение с диагнозом «острая крапивница». Количество мальчиков составило 43 (53,7%), девочек – 37 (46,3%). В контрольную группу вошли 20 практически здоровых детей. Средний возраст детей составил (7,48±0,39) года. Уровень содержания интерлейкинов IL-9, IL-17 и TNFβ в периферической крови был определен у 70 пациентов с острой крапивницей и 20 здоровых детей контрольной группы методом твердофазного иммуноферментного анализа из единой пробы сыворотки крови. Межгрупповые показатели сравнивали с применением критерия χ2 Пирсона (Pearson Chi-Square – рχ2), с дополнительным уточнением результатов критерием U Манна – Уитни (U-Mann – Whitney – pU). Внутригрупповые сравнения проводили критериями W Вилкоксона (Wilcoxon test – pW) и Z-знаков (Sign test – pZ). Результаты. Острая крапивница у детей сопровождалась гиперпродукцией в крови провоспалительных цитокинов. Отмечалось достоверное повышение уровня IL-9 (р < 0,000) и IL-17 (р < 0,000) в крови у детей с острой крапивницей и отеком Квинке. Установленные межсистемные связи выявили достоверную корреляцию между клиническими симптомами острой крапивницы и повышенными уровнями содержания провоспалительных цитокинов IL-9 и IL-17, а также достоверную корреляционную связь между повышенными уровнями содержания в крови IL-9, IL-17 и представителями кишечной микробиоты. Заключение. Результаты исследования свидетельствуют о важной роли цитокинов в патогенезе острой крапивницы и отека Квинке, а также об участии кишечной микрофлоры в развитии данной патологии у детей. Introduction. The study of the cytokine profile of patients suffering from urticaria is decisive in understanding mechanisms of development of various forms of the disease. Purpose. To determine cytokines (IL-9, IL-17, TNFβ) levels in children with acute urticaria. Materials and methods. We examined 80 children of both genders admitted under observation with diagnosis of acute urticaria. The number of boys was 43 (53.7%), girls – 37 (46.3%). The control group consisted of 20 practically healthy children. The average age of the children was 7.48±0.39 years. The level of interleukins IL-9, IL-17 and TNFβ in peripheral blood was determined in 70 patients with acute urticaria and 20 healthy children of the control group by enzyme-linked immunosorbent assay from a single blood serum sample. Intergroup indicators were compared using the χ2-Pearson test (Pearson Chi-Square – pχ2), with additional refinement of the results by the U-Wilcoxon test (U-Mann-Whitney – pU). Intragroup comparisons were performed using W-Wilcoxon test (Wilcoxon test – pW) and Z-signs (Sign test – pZ). Results. Acute urticaria in children was accompanied by hyperproduction of pro- inflammatory cytokines in the blood. There was a significant increase in IL-9 (p < 0.000) and IL-17 (p < 0.000) levels in the blood of children with acute urticaria and Quincke’s edema. The established intersystem relationships revealed a significant correlation between clinical symptoms of acute urticaria and elevated levels of pro-inflammatory cytokines IL-9 and IL-17, as well as a significant correlation between elevated blood levels of IL-9, IL-17 and representatives of intestinal microbiota. Conclusion. The results of the study indicate the important role of cytokines in the pathogenesis of acute urticaria and Quincke’s edema, as well as the participation of intestinal microflora in the development of this pathology in children.

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Features of the functioning of innate immunity in children with chronic idiopathic urticaria

2022

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Aim. To study the features of the functioning of innate immunity in children with chronic idiopathic urticaria.Materials and methods. The study included 28 children of both sexes aged 6–16 years with chronic idiopathic urticaria (CIU). The median age of the patients was 8 years (p = 0.045). Clinical research methods included an analysis of complaints and anamnestic data, as well as an objective examination of the child (dynamics of urticaria, severity of itching, the presence of angioedema). Immunological techniques included determination of the number of monocytes expressing CD14+CD282+, CD14+CD284+, CD14+CD289+, the number of peripheral blood lymphocytes expressing CD3+CD16+, the levels of immunoglobulin (Ig) E, lactoferrin, interferon (IFN) γ, interleukin (IL)4, and IL-6, and a nitroblue tetrazolium test.Results. In the course of the study, an increase in the expression of Toll-like receptors TLR2 and TLR4 by monocytes, a decrease in the expression of TLR9 by monocytes, a significant rise in lactoferrin levels, a slight decrease in the number of natural killer (NK) cells, a decrease in microbicidal activity and adaptive reserves, a rise in IgE levels, a decrease in IL-4 levels, and an increase in IFNγ and IL-6 were revealed in children with CIU.Conclusion. The immunological changes revealed during the study indicate multidirectional expression of Toll-like receptors, disturbances in the work of the cellular components of innate immunity, and a launch of a proinflammatory cytokine cascade in children with CIU, which can serve as a mainstay for the development of new schemes for personalized therapy of CIU in children.

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Cytokine status disorders in children with urticaria

Cited by 3 publications

References 3 publications

CNP model intervention effect on acute urticaria patients’ psychological status, compliance, and life quality

CNP model intervention effect on acute urticaria patients’ psychological status, compliance, and life quality

Features of Cytokine Status in Children with Acute Urticaria

Features of the functioning of innate immunity in children with chronic idiopathic urticaria

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