Influence of vitamin D on the immune response  of the organism

Захарова, И. Н.; Мальцев, С. В.; Заплатников, А Л; Klimov, Leonid; Pampura, A N; Kur'yaninova, Viktoriia A.; Berezhnaya, I. V.; Zhdakaeva, E.D.; Симакова, М. А.; Цуцаева, А. Н.; Dolbnya, Svetlana; Verisokina, Natalia; Krushelnitsky, Anatolii A.; Makhaeva, A.V.; Sychev, Dmitrii A.; No, Moscow Children's City Clinic

doi:10.26442/26586630.2020.2.200238

Cited by 5 publications

(1 citation statement)

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“…Установлено, что кальцитриол регулирует несколько механизмов противовирусного иммунитета [10,11], в т. ч. экспрессию рецепторов распознавания микробных паттернов (PRR), синтез антимикробных пептидов и цитокинов, образование Т-регуляторных лимфоцитов [10].…”

Section: иммунный ответ на респираторные вирусы и его модуляция витам...unclassified

Vitamin D supply, respiratory viral infections and persistent wheezing in children: how significant is the relationship?

Barycheva,

Dolbnya,

Tolkunova

et al. 2024

Medicinskij sovet

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The review discusses the multifaceted effect of vitamin D on antiviral immunity, induction of antimicrobial peptides, functional activity of immunocompetent cells, autophagy processes, clearance of viruses and viral fragments. The relationship between vitamin D and allergic inflammatory cells, its modulating and tolerogenic potential is considered. The inhibitory effect of vitamin D on eosinophils, mast cells, the production of pro-inflammatory and proallergic mediators, and the synthesis of IgE has been shown. The protective role of vitamin D in the development of remodeling and hyperresponsiveness of the respiratory tract has been established by reducing the number of goblet cells, mucus hypersecretion, and the expression of metalloproteinases. The effects of vitamin D on the replication of respiratory viruses and experimental resistance to them through the induction of antimicrobial peptides and other mechanisms have been demonstrated. Data from clinical studies on the preventive effect of vitamin D on the incidence of respiratory infections and episodes of persistent wheezing in children are presented. Children with respiratory syncytial infection and vitamin D deficiency were more likely to require respiratory support and mechanical ventilation. The preventive role of vitamin D in the development of obstructive bronchitis in children and severe bronchiolitis in infants has been shown. It has been established that normal levels of 25(OH)D in the mother significantly reduce the risk of developing bronchial obstruction in the child. Alternative data that do not support a protective effect of vitamin D on respiratory morbidity and wheezing in children are discussed. Further monitoring studies that take into account geographic location and analysis of the dose of cholecalciferol used to assess its preventive role in the development of wheezing and bronchial asthma in children are advisable.

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Section: иммунный ответ на респираторные вирусы и его модуляция витам...unclassified

Vitamin D supply, respiratory viral infections and persistent wheezing in children: how significant is the relationship?

Barycheva,

Dolbnya,

Tolkunova

et al. 2024

Medicinskij sovet

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Impact of compliance with cholecalciferol administration on the incidence of respiratory infections in young children

et al. 2020

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Резюме Введение. Несколько десятилетий назад впервые появились данные о наличии рецепторов к витамину D (VDR) на поверхности различных клеток организма человека, что послужило предпосылкой к исследованиям об изучении роли витамина D в развитии ряда заболеваний, в т. ч. и инфекционных. Цель работы. Оценка взаимосвязи между приемом препаратов холекальциферола, синтезом дефензинов, а также частотой и структурой заболеваемости острыми респираторными инфекциями у детей раннего возраста. Материал и методы. Обследовано 108 здоровых детей в возрасте от 1 мес. до 3 лет, из которых адекватно обеспеченных витамином D-34 (31,5%), с недостаточностью-40 (37,0%), дефицитом витамина D-27 (25,0%) и тяжелым дефицитом-7 (6,5%) детей. После курса коррекции гиповитаминоза D лечебными дозами всем пациентам назначалась профилактическая доза препаратов холекальциферола (1000 МЕ/сут) курсом 6 мес. Результаты. Лечебные дозы холекальциферола способствовали приросту β1-и β2-дефензина, между суточной дозой витамина D и приростом β2-дефензина выявлена прямая корреляционная связь (г = 0,34, р < 0,05). Прием профилактической дозы холекальциферола 1000 МЕ/сут в течение 6 мес. сопровождался дальнейшим увеличением продукции АМП-уровень β1-дефензина вырос в 2,4 раза (р < 0,001), а уровень β2-дефензина-в 2,5 раза (р < 0,001) по сравнению с исходными значениями. На фоне проводимой дотации препаратами холекальциферола частота респираторной заболеваемости составила 1,7 ± 0,2 раза в 6 мес. В группе детей с оптимальной обеспеченностью витамином D имелось достоверно большее число неболевших по сравнению с группами детей с недостаточностью и дефицитом витамина D. Выводы. Прием препаратов витамина D способствует приросту уровней антимикробных пептидов и снижает частоту и тяжесть острых респираторных инфекций у детей раннего возраста.

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Barrier function of the skin and the role of fat-soluble vitamins in the correction of its disorders

Petrova

Albanova

2022

Vestnik dermatologii i venerologii

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The main function of the skin is to protect the body from negative environmental influences. The physical barrier permeability is mainly represented by the stratum corneum; however, other layers of the epidermis and the dermis are its important components. The mechanical strength of the skin is provided by intercellular contacts in the epidermis and structural proteins of the dermis. The chemical-biological barrier includes lipids, acids, natural moisturizing factor and antimicrobial peptides. Mucosal immunity system creates a barrier against infection. The microflora of healthy skin counteracts its colonization by pathogens and is vital for its immune functions. Physiological processes in the skin are closely related. A violation in one of them often leads to the formation of a whole cascade of pathological reactions affecting all the links of its protection. Vitamins A, D and E are used to correct impaired barrier function of the skin. The most pronounced effect of vitamin A (retinol palmitate) is the proliferation of epidermal cells and synthesis of extracellular matrix structures of the dermis; vitamin D (cholecalciferol) regulation of differentiation and suppression of excessive proliferation of keratinocytes; vitamin E (tocopherol acetate) antioxidant effect. The combined use of these vitamins in the composition of RadevitActive ointment affects all the main elements of the protection of the epidermis and dermis: strengthens the mechanical strength of the stratum corneum and dermis, stabilizes chemical and physical protection, including prevents the penetration of foreign substances and microorganisms, reduces transepidermal loss of water and electrolytes, reduces the damaging effect of UV, increases antimicrobial and antioxidant protection.

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Influence of vitamin D on the immune response of the organism

Cited by 5 publications

References 0 publications

Vitamin D supply, respiratory viral infections and persistent wheezing in children: how significant is the relationship?

Vitamin D supply, respiratory viral infections and persistent wheezing in children: how significant is the relationship?

Impact of compliance with cholecalciferol administration on the incidence of respiratory infections in young children

Barrier function of the skin and the role of fat-soluble vitamins in the correction of its disorders

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