Leukoplakia of the oral mucosa is characterized by impairment of the epithelial differentiation program. The use of complex phytoadaptogen in the treatment of patients with leukoplakia normalized expression of Fas-APO-1 antigen and keratin 17; increased expression of CD54 attested to activation of immune effectors. The clinical effect manifested in involution or shrinkage and loosening of the pathological focus and complete epithelialization of erosive surfaces. The phytopreparation exhibited adaptogenic effects normalizing the immune and IFN status and improving the state of adaptation systems in the body.
Phytoadaptogens (ginseng, eleutherococcus, rhodiola rosea, aralia, etc.) have a wide spectrum of biological activity, supporting the body in a state of nonspecific increased resistance to stress. The second part of the review provides information of the phytoadaptogens normalizing effects on the cardiovascular system. Analyzes current data on the antitumor properties of phytoadaptogens in relation to the effect on the onset and development of tumours, metastasis, recurrence, development of cytostatic disease, confirming the prospect of their using in drugs for prevention and biotherapy of tumour diseases.Past 1 see: Phytoadaptogens in the tumours biotherapy and geriatrics (Past 1). Russian Journal of Biotherapy 2020;19(2):13–21.
The efficiency of treatment of diffuse stomach cancer can be improved by using a complex phytoadaptogen. In groups receiving phytoadaptogen, the level of tumor marker CA 19-9 decreased and the mean life span of patients increased by 2.5 times. The drug exhibited immunomodulating (including interferonogenic and adhesiogenic), antioxidant, and hormone-modulating effects.
We studied the influence of nontoxic phytoadaptogen complex on the lifespan and somatic status (body weight, coat state, and motor activity) of CBA mice predisposed to spontaneous hepatomas. Administration of the complex phytoadaptogen during the first month of postnatal ontogeny increased mean animal lifespan by 17.1% (p<0.001) and median of survival by 25.6% (p<0.001) and promoted maintenance of satisfactory physical status of CBA mice during spontaneous hepatocarcinogenesis.
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