Therapeutic efficacy of the plant neuroprotector Phytomix-40 in Parkinson's disease was demonstrated. This preparation consists of the components from extracts of 40 plants, including some adaptogens (ginseng, eleutherococcus, Rhodiola rosea, etc.). The preparation normalized immune, antioxidant, and hormonal parameters in patients. The neuroprotective plant adaptogen can be used in complex therapy for Parkinson's disease for improving its efficacy.
Leukoplakia of the oral mucosa is characterized by impairment of the epithelial differentiation program. The use of complex phytoadaptogen in the treatment of patients with leukoplakia normalized expression of Fas-APO-1 antigen and keratin 17; increased expression of CD54 attested to activation of immune effectors. The clinical effect manifested in involution or shrinkage and loosening of the pathological focus and complete epithelialization of erosive surfaces. The phytopreparation exhibited adaptogenic effects normalizing the immune and IFN status and improving the state of adaptation systems in the body.
Oligo(hexamethyleneguanidine) (OHMG) hydrochloride samples with various molecular weights that were synthesized from hexamethylenediamine and guanidine hydrochloride were characterized by 13 C NMR, ultracentrifugation, and capillary viscosimetry techniques. It was found that OHMG hydrochloride has 0.16 -1.08 branching points per molecule. Number-average molecular weights M n and weight-average molecular weights M w were calculated from 13 C NMR and ultracentrifugation data. A comparative analysis of these characteristics shows that the synthesized oligomers have a wide molecular-weight distribution (M w /M n = 5.4 -9.3).
Phytoadaptogens (ginseng, eleutherococcus, rhodiola rosea, aralia, etc.) have a wide spectrum of biological activity, supporting the body in a state of nonspecific increased resistance to stress. The second part of the review provides information of the phytoadaptogens normalizing effects on the cardiovascular system. Analyzes current data on the antitumor properties of phytoadaptogens in relation to the effect on the onset and development of tumours, metastasis, recurrence, development of cytostatic disease, confirming the prospect of their using in drugs for prevention and biotherapy of tumour diseases.Past 1 see: Phytoadaptogens in the tumours biotherapy and geriatrics (Past 1). Russian Journal of Biotherapy 2020;19(2):13–21.
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