Structure and molecular-weight characteristics of oligo(hexamethyleneguanidine) hydrochlorides

Кедик, С. А.; Бочарова, О. А.; An, Ha Kam; Панов, Алексей Валерьевич; Sedishev, I. P.; Жаворонок, Е. С.; Тимофеева, Г. И.; Suslov, V. V.; Beksaev, S. G.

doi:10.1007/s11094-011-0519-9

Cited by 11 publications

(8 citation statements)

References 11 publications

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“…Injectable depot forms of microparticles (administered intramuscularly or subcutaneously) provide a controlled release of active compounds over weeks and even months, thereby demonstrating a huge advantage over classical dosage forms that, commonly, require daily administration to maintain a therapeutically effective concentration in the blood. Dozens of prolonged release drugs based on PLGA microparticles are used in clinical practice for the treatment of alcohol dependence, cancer, schizophrenia, and many other diseases [37]. We are happy to note that some of them are manufactured in Russia.…”

Section: Preparation Of Nanoparticles Based On Poly(lactide-co-glycolide)mentioning

confidence: 99%

Nanoformulations of Drugs Based on Biodegradable Lactide Copolymers with Various Molecular Structures and Architectures

et al. 2021

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Modern pharmaceutics are actively developing towards the design of targeted drugs. The development of selectively acting formulations requires the creation of smart delivery systems based on carriers that would first find the target cells and enter them and then release the active substance locally. Nanoparticles of biocompatible and biodegradable polymers can be effectively used as such carriers. Flexible regulation of the molecular structure and architecture of polymers, as well as the modification of nanoparticles with vector molecules, allows one to construct carrier particles for the development of nanoformulations for active agents of various nature. This review presents the main approaches to the design of nanoformulations for targeted delivery, describes the methods for the preparation and study of nanoparticles based on hydrophobic and amphiphilic biodegradable lactide polymers, and discusses the effect of the molecular structure and preparation conditions on the characteristics of nanoparticles in detail. Some results of research in this area of the Kurchatov complex of NBIСS nature-like technologies are also presented.

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Section: Preparation Of Nanoparticles Based On Poly(lactide-co-glycolide)mentioning

confidence: 99%

Nanoformulations of Drugs Based on Biodegradable Lactide Copolymers with Various Molecular Structures and Architectures

et al. 2021

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“…Sample of branched OHMG hydrochloride ("DEZAPOL ® ") was obtained from Institute of Pharmaceutical Technologies (Moscow, Russia), number-average OHMG molecular weight is 750 Da, average number of branchings is 0.25 to per molecule [12].…”

Section: Branched Ohmg Hydrochloridementioning

confidence: 99%

“…Branched oligo(hexamethyleneguanidine) (OHMG) hydrochloride ( Figure 1) can be used in medical practice for treating viral and infectious dental diseases because of their highly effective action and low toxicity [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of branched oligo(hexamethyleneguanidine) hydrochloride on oral pathogens

Shatalov¹,

Кедик²,

Панов³

et al. 2018

Russ Open Med J

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The present work is devoted to study of the antimicrobial activity of a new promising synthetic biocidal compound, branched oligohexamethylene guanidine hydrochloride. The studies were carried out using optional anaerobic bacteria Staphylococcus aureus and Klebsiella pneumoniae, as well as obligate anaerobic bacteria Actinomyces pyogenes, Actinomyces odontolyticus, Peptostreptococcus micros, Finegoldia magna, Veillonella parvula, Prevotella disiens and Fusobacterium nucleatum. It was shown that branched oligohexamethylene guanidine hydrochloride inhibits the growth of these bacteria, and facultative anaerobic bacteria are more sensitive to it. The assumptions about the mechanism of this activity of branched oligohexamethylene guanidine hydrochloride are made. The results of the study show that the substance can be recommended as a broad-spectrum biocide.

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“…It is known that the biodegradation processes are influenced by the chemical composition including a ratio of links of monomers, possible influence of drug substances [10]. Therefore, for confirmation of the offered field of use of the developed film materials with tiamulin fumarate as devices of medical use it is expedient to investigate the influence of the model biological medium on their structure and properties.…”

Section: Introductionmentioning

confidence: 99%

Study of Biodegradation, Biocompatibility and Bactericidal Activity of Film Materials with Tiamulin Fumarate Based on Polyurethaneurea

Rudenchyk¹,

Rozhnova²,

Galatenko³

et al. 2020

ChChT

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The influence of the model biological medium 199 on the structure and properties of film materials with tiamulin fumarate based on polyurethaneurea containing in its structure the hydrophilic fragments of the copolymer of N-vinylpyrrolidone with vinyl acetate and vinyl alcohol has been investigated. According to IR spectroscopy, under the influence of the biological medium 199 there are processes of biodegradation of polymer materials which are accompanied by a decrease in the intensity of the absorption band ν С=О of vinylpyrrolidone ring. It is established that the introduction of tiamulin fumarate into polyurethaneurea facilitates their biodegradation, as evidenced by a decrease of the tensile strength (1.28-2.38 times) and a relative elongation at break (1.36-1.82 times) after incubation in the biological medium 199 by physicomechanical tests. The tissue culture method has established the biocompatibility of film materials with tiamulin fumarate. According to the results of microbiological studies, bactericidal properties were observed in relation to the bacteria Staphylococcus aureus and Escherichia coli. It allows using them for production of drainage in abdominal surgery.

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Structure and molecular-weight characteristics of oligo(hexamethyleneguanidine) hydrochlorides

Cited by 11 publications

References 11 publications

Nanoformulations of Drugs Based on Biodegradable Lactide Copolymers with Various Molecular Structures and Architectures

Nanoformulations of Drugs Based on Biodegradable Lactide Copolymers with Various Molecular Structures and Architectures

Antimicrobial activity of branched oligo(hexamethyleneguanidine) hydrochloride on oral pathogens

Study of Biodegradation, Biocompatibility and Bactericidal Activity of Film Materials with Tiamulin Fumarate Based on Polyurethaneurea

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