Prospects of Using Phytoadaptogen in the Treatment of Diffuse Stomach Cancer

Бочарова, О. А.; Давыдов, М. И.; Klimenkov, A. A.; Baryshnikov, A. Yu.; Карпова, Р. В.; Chulkova, S. V.; Gorozhanskaya, E. G.; Ilyenko, V. A.

doi:10.1007/s10517-009-0652-6

Cited by 11 publications

(5 citation statements)

References 7 publications

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“…MPhA also showed high antioxidant activity -suppressed lipid peroxidation with a decrease in the level of malondialdehyde, activation of catalase and glutathione antiperoxide system. [69][70][71] The adhesive properties of MPhA are also shown on the example of precancer -oral leukoplakia confirming experimental studies on high-cancer CBA mice. Under the influence of MPhA on the epithelial cells of the leukoplakia lesions an increase in the expression of ICAM-1 adhesion molecules (ligands of beta2 integrins on immune effectors) was shown, a growth in the expression of receptors mediating apoptosis (Fas APO1) was noted as well as a decrease in the expression of the protein-marker of immature epithelial cells (keratin 17).…”

Section: Studies In the Clinicmentioning

confidence: 61%

“…In addition, the antistress activity of MPhA was determined in these patients ‐ a decrease in the level of the stress hormone cortisol. MPhA also showed high antioxidant activity – suppressed lipid peroxidation with a decrease in the level of malondialdehyde, activation of catalase and glutathione antiperoxide system [69–71] …”

Section: Resultsmentioning

confidence: 98%

“…In addition, MPhA administration with conventional treatment of gastric cancer almost duplicated the number of polychemotherapy courses ‐ 72 and 43 in the control. So, MPhA can be used by cancer patients with conventional treatment to slow down the tumor process and decrease the side effects of chemotherapy [71] …”

Section: Resultsmentioning

confidence: 99%

“…So, MPhA can be used by cancer patients with conventional treatment to slow down the tumor process and decrease the side effects of chemotherapy. [71] As a result of MPhA use in patients with BPH a decrease (almost 3 times) in the age level of the chromosomal aberrations frequency in peripheral blood lymphocytes was also revealed. Administration of MPhA produced this parameter in lymphocytes of the patients lower than average population value in Russia and lower than that of the control groups without contacts with bad ecology as well as with industrial and household hazards.…”

Section: Studies In the Clinicmentioning

confidence: 96%

“…So, in the clinic and in the experimental researches the immunomodulatory effect of MPhA was revealed that was seen in the normalization of the T-and B-cell immunity as well as in the increase of NK cells level and growth of IL-2 receptors expression. [68][69][70][71] At the same time the use of MPhA in Parkinson's disease led to the suppression of negative activation of immune system cells showing antiinflammatory activity. [72] The interferon-inducing effect of MPhA was also revealed.…”

Section: Studies In the Clinicmentioning

confidence: 99%

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Computer‐aided Evaluation of Polyvalent Medications’ Pharmacological Potential. Multiphytoadaptogen as a Case Study

Бочарова¹,

Ионов

Казеев³

et al. 2022

Molecular Informatics

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Many human diseases including cancer, degenerative and autoimmune disorders, diabetes and others are multifactorial. Pharmaceutical agents acting on a single target do not provide their efficient curation. Multitargeted drugs exhibiting pleiotropic pharmacological effects have certain advantages due to the normalization of the complex pathological processes of different etiology. Extracts of medicinal plants (EMP) containing multiple phytocomponents are widely used in traditional medicines for multifactorial disorders' treatment. Experimental studies of pharmacological potential for multicomponent compositions are quite expensive and time-consuming. In silico evaluation of EMP the pharmacological potential may provide the basis for selecting the most promising directions of testing and for identifying potential additive/ synergistic effects. Multiphytoadaptogen (MPhA) containing 70 major phytocomponents of different chemical classes from 40 medicinal plant extracts has been studied in vitro, in vivo and in clinical researches. Antiproliferative and anti-tumor activities have been shown against some tumors as well as evidencebased therapeutic effects against age-related pathologies. In addition, the neuroprotective, antioxidant, antimutagenic, radioprotective, and immunomodulatory effects of MPhA were confirmed. Analysis of the PASS profiles of the biological activity of MPhA phytocomponents showed that most of the predicted anti-tumor and anti-metastatic effects were consistent with the results of laboratory and clinical studies. Antimutagenic, immunomodulatory, radioprotective, neuroprotective and anti-Parkinsonian effects were also predicted for most of the phytocomponents. Effects associated with positive effects on the male and female reproductive systems have been identified too. Thus, PASS and PharmaExpert can be used to evaluate the pharmacological potential of complex pharmaceutical compositions containing natural products Keywords: natural products • multiphytoadaptogen • pharmacological potential • PASS • PharmaExpert • in silico estimation • in vitro and in vivo validation • clinical studies

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Section: Studies In the Clinicmentioning

confidence: 61%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Studies In the Clinicmentioning

confidence: 96%