Integrins LFA-1 and Mac-1 and Cytokines IL-6 and IL-10 in High-Cancer Mice under the Influence of Phytoadaptogen

Abstract

The expression of leukocyte integrins LFA-1 and Mac-1 and cytokines IL-6 and IL-10 was studied in mice predisposed to spontaneous hepatocarcinomas. The efficacy of a phytoadaptogen in correcting these parameters was evaluated. The role of adhesive interactions between immune cells and target cells in the recovery of antitumor regulatory mechanisms was estimated.

Computer‐aided Evaluation of Polyvalent Medications’ Pharmacological Potential. Multiphytoadaptogen as a Case Study

“…This leads to increased expression of beta 2 leukocyte integrins LFA‐1 and Mac‐1 ‐ ligands of histo‐nonspecific adhesion molecules ICAM‐1,2 on tumor cells. In this way the regulation of heterotypic adhesive interactions that cause the attachment of immune effectors to tumor cells can be restored contributing to the elimination of the latter [59,60] …”

“…In this way the regulation of heterotypic adhesive interactions that cause the attachment of immune effectors to tumor cells can be restored contributing to the elimination of the latter. [59,60] Prevention of dopaminergic neurons loss in the brain was accompanied by a decrease in the level of tumor formation, an increase in lifespan and maintenance of somatic status with correction of the stress hormone corticosterone serum level. Consequently, it is possible to assume control of the hepatocarcinogenesis process with increased antitumor protection and weakening of stress mechanisms including the participation of peripheral dopamine high content justifying the properties of the latter known from the literature as a stress regulator, antitumor agent and geroprotector.…”