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Цель-изучение результатов оперативного лечения кардиохирургических пациентов с фибрилляцией предсердий с использованием насыщающей дозы амиодарона до оперативного лечения. Материал и методы. В исследование вошли 49 пациентов с фибрилляцией предсердий, проходивших хирургическое лечение с 2013 по 2014 г. (14 месяцев). Первую группу составили 23 больных, получавших до операции насыщающую дозу амиодарона 0,6-1 г/сут, после операции-поддерживающую дозу 0,4 г/сут в раннем послеоперационном периоде и 0,2 г/сут в период до 6 месяцев. Во вторую-контрольную-группу вошли 26 пациентов, получавших насыщающую дозу амиодарона 0,6-1 г/сут после операции. Результаты. Сохранность синусового ритма после выполнения процедуры левопредсердной Maze IV отмечена у 44 (90%) пациентов. При этом рецидив фибрилляции предсердий отмечен у 1 больного из 1-й группы и у 4 из 2-й группы. У всех 5 пациентов с возвратом стойкой фибрилляции предсердий диагностирована длительно персистирующая форма с аритмическим анамнезом более 3 лет, а также по данным эхокардиографии выявлена дилатация левого предсердия более 6 см. Заключение. Применение насыщающей дозы амиодарона до оперативного вмешательства улучшает результаты процедуры левопредсердной Maze IV (до 95%) в сравнении с назначением амиодарона после операции (до 85%).

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Background. The last researches offer to conduct the study of Alzheimer disease (AD) mechanisms using diverse experimental models. However, it was not investigated the behavioral and cognitive impairment in rats at the different stages of vascular model of dementia of Alzheimer’s type developed by us. Subjects and methods. The experiment was performed on 32 male WAG rats weighing 180-250 g which were divided into 4 groups. Rats from group 1 and 3 were injected by aqueous solution of sodium nitrite at a dose of 50 mg/kg of body mass intraperitoneally during 14 and 28 days respectively. Groups 2 and 4 were received 500,000 mesenchymal stem cells in suspension intravenously against the background of experimental nitrite-induced AD. To estimate the behavioral reactions and cognitive functions the Open Field Test (OFT) and Passive Avoidance test (PAT) were used. Results. In all experimental groups in most cases it was found the significant decrease in vertical and horizontal activity (p <0,05) and an increase in the number of defecation in the OFT. Rats from group 3 had the drop in locomotor, research and orientation activity. In the OFT and PAT in groups 2,4 it was observed an improvement in research activity and significant cognitive functions recovery (p=0,012) after stem cell correction. Conclusions. It was found the progression of the protective inhibition and cognitive impairment during experiment. The stem cells introduction had positive effects on brain function recovery.

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Introduction More often, cardiac surgery patients (CSP) receive systematic psychological aid after surgery. However, their need for psychosocial interventions in the perioperative period is underestimated. Objectives The goal is to determine the stages of psychosocial interventions for CSP that could cover the whole period of their treatment and rehabilitation. Methods Analysis of scientific papers and practical experience gained in cardiologic clinic allowed dividing the system of psychosocial interventions for cardiac surgery patients into periods in accordance with actual stages of medical aid for CSPs. Results According to the principles of personalized approach, we determined six consecutive semantically different stages of psychosocial interventions: out-of-hospital pre-surgery, in-hospital pre-surgery, early post-surgery, in-hospital post-surgery, post-surgery rehabilitation, and out-of-hospital rehabilitation. They have different duration and cover the whole period of treatment and rehabilitation of CSPs beginning with the moment of indication to surgery up to the complete rehabilitation and full adaptation to their post-surgery somatic condition. Each stage has its own goals, main objectives and expectations. Duration of the stages is conditional and can change depending on the nature of every clinical situation. Conclusions Determination of clinical stages in the process of psychosocial interventions for CSPs gives ground for selecting optimal psychological methods and techniques for each stage and sets exact goals, achievement of which becomes possible only through a properly organised work of an interdisciplinary team of specialists. Disclosure No significant relationships.