The aim: To assess carbohydrate and lipid metabolic profiles of tuberculosis patients with bilateral injuries of the lungs and mycobacteria excretion.
Materials and methods: Seventy two newly diagnosed pulmonary TB patients were examined. Group I – 17 newly diagnosed TB patients who had unilateral pulmonary lesions
and had no mycobacteria excretion. Group II – 55 newly diagnosed TB patients who had bilateral pulmonary lesions and mycobacteria excretion. The control group included 20
healthy persons. Fasting insulin level, indices of lipidogram were measured, oral glucose tolerance test was performed. Statistical processing of the obtained results was carried
out by analyzing the contingency tables using the StatisticaBasicAcademic 13 for Windows software package.
Results: Tuberculosis patients develop insulin resistance – condition that is a precursor to developing type 2 diabetes and metabolic disorder of lipid exchange – dyslipidemia.
Patients with bilateral pulmonary lesions and mycobacteria excretion have the most pronounced disorders of carbohydrate and lipid metabolism compared to patients with
limited lesions of the lungs.
Conclusions: We suppose that mycobacteria excretion and bilateral lesions of lungs may be the markers of the degree of carbohydrate and lipid metabolism disorders in patients
with pulmonary tuberculosis.
KEY WORDS: pulmonary tuberculosis, mycobacteria excretion, glucose metabolism, lipidogram
Background and aimsOne of the most severe manifestation displays of tuberculosis (TB) generalization is meningitis/meningoencephalitis. The purpose of this work was to improve the diagnostic efficiency of TB central nervous system (CNS) affection in human immunodeficiency virus (HIV)-infected persons.Materials and methodsMeninges and cerebral tissues, taken from died patients, who were HIV-infected and dead from TB of CNS affection, were investigated histologically.Results and discussionOur examination showed that clinical course of the pathologic process loses the peculiarity of TB-undulating character, and changes in tissues have monomorphism that appears in the presence of the same type of granulomas with a few Pirogov–Langhans cells. Alterative reactions with formation of the large fields of caseous necrosis, necrotic focuses, areas of infiltration with polymorphic cellular elements went out on the first plan in the disorder of cerebrum in patients with the terminal stage of HIV infection. The tendency to decrease in inflammatory–proliferative processes was observed, which is confirmed by the presence of the poorly expressed cellular reaction on the peripheries of focuses of caseous necrosis.ConclusionMorphologic features of tuberculous meningoencephalitis in HIV-infected patients are the presence of edema, gliosis, trombovasculitis, small focal hemorrhage, tuberculous granuloma formation with a small number of Pirogov–Langhans cells, and the prevalence of alterative–exudative reactions.
La dynamique du niveau de l'aldostérone, de la réorganisation du tissu conjonctif et du taux de glucose comme marqueurs de l'efficacité du traitement de la tuberculose Objectif. L'étude visait à évaluer la dynamique de la réorganisation du tissu conjonctif, les taux d'aldostérone et de glucose en tant que marqueurs de l'évolution favorable de la tuberculose pulmonaire multirésistante. Matériels et méthodes. L'étude a été réalisée sur 84 patients atteints de tuberculose pulmonaire multirésistante diagnostiquée pour la première fois. Les taux d'aldostérone, d'hydroxyproline et de glucose libres et liés aux protéines ont été mesurés chez tous les patients.
BackgroundMultidrug-resistant tuberculosis (MDRTB) remains a health problem for many countries in the world. The share of MDRTB is 10–30% among newly diagnosed cases and 20–70% among relapses and treatment failure. The aim of the study is to define the side effects of second line drugs used in the treatment of MDRTB on thyroid function.MethodsIn 30 patients with multidrug resistant tuberculosis, echostructure of thyroid was studied by ultrasound imaging method. Indices of thyroid function: plasma levels of free thyroxin, thyroid stimulating hormone were studied before chemotherapy initiated, at the end of intensive phase and after the treatment finished.ResultsDecreasing of thyroid function under antituberculosis chemotherapy was approved. Monitoring and correction of thyroid function during antituberculosis chemotherapy was suggested.ConclusionPatients with MDRTB taking ethionamide and PAS are at increased risk for hypothyroidism and goiter, and therefore require monitoring of thyroid function at all stages of antituberculosis chemotherapy for its timely correction.
In different types of substrate (soil, litter, lichens and mosses) collected at three memorial complexes (cemeteries) of Kyiv (Ukraine), 70 species from 57 genera, 34 families of oribatid mites were found. A few eurytopic species capable of tolerance to different types of pollution make up an essential part in each species complex. The species diversity and complexity of oribatid community structure at researched areas increased with distance from the city center. There was no direct relation between the degree of dominance of most common species and the cemetery’s relative remoteness from the center of the city.
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