We have developed a new core@shell composition system ZnFe2O4@MnFe2O4 for the full cycle of cancer treatment. During the study, the effect of the influence of particles on MRI diagnostics, radiotherapy and magnetic hyperthermia was evaluated.
Magnetic nanoparticles are a prospective class of materials for use in biomedicine as agents for magnetic resonance imagining (MRI) and hyperthermia treatment. However, synthesis of nanoparticles with high efficacy is resource‐intensive experimental work. In turn, the use of machine learning (ML) methods is becoming useful in materials design and serves as a great approach to designing nanomagnets for biomedicine. In this work, for the first time, an ML‐based approach is developed for the prediction of main parameters of material efficacy, i.e., specific absorption rate (SAR) for hyperthermia and r1/r2 relaxivities in MRI, with parameters of nanoparticles as well as experimental conditions as descriptors. For that, a unique database with more than 980 magnetic nanoparticles collected from scientific articles is assembled. Using this data, several tree‐based ensemble models are trained to predict SAR, r1 and r2 relaxivity. After hyperparameter optimization, models reach performances of R2 = 0.86, R2 = 0.78, and R2 = 0.75, respectively. Testing the models on samples unseen during the training shows no performance drops. Finally, DiMag, an open access resource created to guide synthesis of novel nanosized magnets for MRI and hyperthermia treatment with machine learning and boost development of new biomedical agents, is developed.
The high-density (with the relative density up to 98,8 %) ultrahigh temperature ZrB2‒TaC‒SiC ceramic materials (UHTCs) were prepared by means of the hot Argon pressing 30 MPa at 2000 °C, and isothermal time 15 minutes. After this the phase composition, crystal lattice parameters, ultimate bending stress, Vickers hardness, and the cracking resistance were investigated. The maximum values of the bent stress, hardness, and cracking resistance were 440 MPa, 20 GPa and 5,3 MPa·m1/2respectively. It was shown that the ZrB2/TaC ration influenced both the crystal lattice spacing and the mechanical properties of the material.Ill. 7. Ref. 50. Tab. 4.
In this work, the effect of the annealing temperature and the chemical history of the precipitate on the morphology and phase composition of the Nb2O5 powder was studied. Nb2O5nH2O precipitate and gel-like niobium citrate were obtained by solution methods. The synthesis of niobium oxide was carried out at temperatures of 600, 1000, and 1200 °C, the synthesis products were analyzed using X-ray diffraction, scanning electron microscopy, X-ray microscopy, and differential thermal and thermogravimetric analysis. Annealing of niobium citrate at a temperature of 600 °C makes it possible to obtain niobium oxide particles with an average size of about 70 nm, which is 4 – 6 times smaller than Nb2O5 obtained from the Nb2O5nH2O precipitate.
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