Multifunctional tunable ZnFe2O4@MnFe2O4 nanoparticles for dual-mode MRI and combined magnetic hyperthermia with radiotherapy treatment

Шабалкин, И. Д.; Komlev, Aleksei S.; Tsymbal, Sergey A.; Burmistrov, Oleg I.; Zverev, V. I.; Krivoshapkin, Pavel V.

doi:10.1039/d2tb02186b

Cited by 13 publications

(6 citation statements)

References 54 publications

(67 reference statements)

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“…Additionally, in terms of RT and magnetic hypermia, Krivoshapkin and his colleagues designed ZnFe 2 O 4 @MnFe 2 O 4 nanocomposites for synergistic RT and magnetic hyperthermia to combat cancer. [ 227 ] The ZnFe 2 O 4 @MnFe 2 O 4 exhibited a remarkable specific absorption rate (SAR) of 8 W g −1 , resulting in a 40% increase in the local irradiation. This increment was determined and calculated based on data both in vitro and in vivo.…”

Section: Combined Treatment Incorporating Radiotherapymentioning

confidence: 99%

Stimuli‐Responsive Nanoradiosensitizers for Enhanced Cancer Radiotherapy

Xiao,

Zhao,

Sun

et al. 2023

Small Methods

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Radiotherapy (RT) has been a classical therapeutic method of cancer for several decades. It attracts tremendous attention for the precise and efficient treatment of local tumors with stimuli‐responsive nanomaterials, which enhance RT. However, there are few systematic reviews summarizing the newly emerging stimuli‐responsive mechanisms and strategies used for tumor radio‐sensitization. Hence, this review provides a comprehensive overview of recently reported studies on stimuli‐responsive nanomaterials for radio‐sensitization. It includes four different approaches for sensitized RT, namely endogenous response, exogenous response, dual stimuli‐response, and multi stimuli‐response. Endogenous response involves various stimuli such as pH, hypoxia, GSH, and reactive oxygen species (ROS), and enzymes. On the other hand, exogenous response encompasses X‐ray, light, and ultrasound. Dual stimuli‐response combines pH/enzyme, pH/ultrasound, and ROS/light. Lastly, multi stimuli‐response involves the combination of pH/ROS/GSH and X‐ray/ROS/GSH. By elaborating on these responsive mechanisms and applying them to clinical RT diagnosis and treatment, these methods can enhance radiosensitive efficiency and minimize damage to surrounding normal tissues. Finally, this review discusses the additional challenges and perspectives related to stimuli‐responsive nanomaterials for tumor radio‐sensitization.

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Section: Combined Treatment Incorporating Radiotherapymentioning

confidence: 99%

Stimuli‐Responsive Nanoradiosensitizers for Enhanced Cancer Radiotherapy

Xiao,

Zhao,

Sun

et al. 2023

Small Methods

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“…[ 24,25 ] Compared with conventional molecular coordination complexes, nanoscale contrast agents show several outstanding advantages, including markedly improved contrast effect, long blood circulation time, and flexible surface chemistry. [ 26 ] Most currently existing nanoparticulate contrast agents are simple nanoparticles without multilevel microarchitecture, [ 19,27 ] whose contrast effect can be optimized by regulating their size, [ 28,29 ] shape, [ 30,31 ] composition, [ 32–35 ] core‐shell structure, [ 36,37 ] crystallinity, [ 38,39 ] surface modification, [ 40,41 ] and assembled structure. [ 42–44 ] Notably, the microhierarchical structure of contrast agents is directly related to the dynamic interactions between water molecules and the magnetic centers, which is an important factor that needs to be manipulated to obtain high‐performance contrast agents.…”

Section: Superiority Of Nano‐metamaterials For Mrimentioning

confidence: 99%

Nano‐Metamaterial: A State‐of‐the‐Art Material for Magnetic Resonance Imaging

Wang

et al. 2023

Small Science

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Metamaterials are artificially designed materials with multilevel‐ordered microarchitectures, which exhibit extraordinary properties not occurring in nature, and their applications have been widely exploited in various research fields. However, the progress of metamaterials for biomedical applications is relatively slow, largely due to the limitations in the size tailoring. When reducing the maximum size of metamaterials to nanometer scale, their multilevel‐ordered microarchitectures are expected to obtain superior functions beyond conventional nanomaterials with single‐level microarchitectures, which will be a prospective candidate for the next‐generation diagnostic and/or therapeutic agents. Here, a forward‐looking discussion on the superiority of nano‐metamaterials for magnetic resonance imaging (MRI) according to the imaging principles, which is attributed to the unique periodic arrangement of internal multilevel structural units in nano‐metamaterials, is presented. Moreover, recent advances in the development of nano‐metamaterials for high‐performance MRI are introduced. Finally, the challenges and future perspectives of nano‐metamaterials as promising MRI contrast agents for biomedical applications are briefly commented.

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“…Zinc ferrite nanoparticles (ZFONPs) are zinc-hybrid ferrite nanoparticles with stronger magnetic properties, higher magnetic resonance (MR) relaxation rates, and magnetically induced temperature rise than conventional Fe 3 O 4 nanoparticles. 29,30 ZFONPs have been reported in cancer studies, for example, as radiosensitizers for the treatment of prostate cancer, to degrade mutant p53 proteins, and for the delivery of chemotherapeutic drugs for breast cancer. 31−33 However, there are no reports on the autophagic effects induced by ZFONPs and their impact on the cell fate.…”

Section: Introductionmentioning

confidence: 99%

“…The preparation of novel high-performance nanoparticles has been a key research priority in the field of nanotechnology. Zinc ferrite nanoparticles (ZFONPs) are zinc-hybrid ferrite nanoparticles with stronger magnetic properties, higher magnetic resonance (MR) relaxation rates, and magnetically induced temperature rise than conventional Fe 3 O 4 nanoparticles. , ZFONPs have been reported in cancer studies, for example, as radiosensitizers for the treatment of prostate cancer, to degrade mutant p53 proteins, and for the delivery of chemotherapeutic drugs for breast cancer. − However, there are no reports on the autophagic effects induced by ZFONPs and their impact on the cell fate. As shown in Scheme , we designed multifunctional nanoparticles for inducing cellular autophagy and enhancing chemotherapeutic effects in ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Aptamer-Modified Zinc Ferrite Nanoparticles for Autophagy-Mediated Chemotherapy and MR Imaging of Ovarian Cancer

Zhu,

Hu,

Yang

et al. 2024

ACS Appl. Nano Mater.

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Chemotherapy resistance is a major cause of the high mortality in ovarian cancer. Therefore, there is an urgent need to develop strategies to increase the sensitivity of ovarian cancer to chemotherapeutic medicines. Here, we synthesized nucleic acid aptamer (NucA)-modified zinc ferrite nanoparticles (NAZs), to induce pro-death autophagy for enhancing the sensitivity of ovarian cancer cells to the chemotherapeutic agent�cisplatin (DDP). First, we verified that zinc ferrite nanoparticles (ZFONPs) effectively induced intact cellular autophagy in SKOV3 cells. Moreover, the use of small-molecule autophagy inhibitors markedly curtailed cell death induced by ZFONPs. Notably, we found that ZFONPs-induced pro-death autophagy was mediated by increasing zinc ion release and thereby intracellular reactive oxygen species (ROS) production. Second, we demonstrated that the modification of ZFONPs with the tumor-targeting aptamer (NucA) endowed the nanoparticles with the ability to target tumor cells. Furthermore, the induction of deathpromoting autophagy by NAZs sensitized ovarian cancer cells to DDP chemotherapy. Significantly, the constructed NAZs exhibited ovarian cancer targeting capabilities, served as T 2 -weighted magnetic resonance imaging (MRI) contrast agents, and enhanced the therapeutic effect of DDP in both in vitro and in vivo experiments. Collectively, these findings present a promising and effective approach for the precise treatment and diagnosis of ovarian cancer.

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Multifunctional tunable ZnFe₂O₄@MnFe₂O₄ nanoparticles for dual-mode MRI and combined magnetic hyperthermia with radiotherapy treatment

Abstract: We have developed a new core@shell composition system ZnFe2O4@MnFe2O4 for the full cycle of cancer treatment. During the study, the effect of the influence of particles on MRI diagnostics, radiotherapy and magnetic hyperthermia was evaluated.

Cited by 13 publications

References 54 publications

Stimuli‐Responsive Nanoradiosensitizers for Enhanced Cancer Radiotherapy

Stimuli‐Responsive Nanoradiosensitizers for Enhanced Cancer Radiotherapy

Nano‐Metamaterial: A State‐of‐the‐Art Material for Magnetic Resonance Imaging

Aptamer-Modified Zinc Ferrite Nanoparticles for Autophagy-Mediated Chemotherapy and MR Imaging of Ovarian Cancer

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