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Орешко Аркадий Юрьевич, преподаватель института остеопатии Мохов Дмитрий Евгеньевич, д. м. н., заведующий кафедрой остеопатии; директор Института остеопатии Орешко Людмила Саварбековна, д. м. н., профессор кафедры пропедевтики внутренних болезней, гастроэнтерологии и диетологии им. С. М. Рысса Трегубова Елена Сергеевна, д. м. н., профессор кафедры остеопатии; доцент Института остеопатии Селиверстов Павел Васильевич, к. м. н., доцент кафедры внутренних болезней и нефрологии Семенова Елена Анатольевна, к. м. н., ассистент кафедры пропедевтики внутренних болезней, гастроэнтерологии и диетологии им. С. М. Рысса

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Regulatory signals in the body are not limited to chemical and electrical ones. There is another type of important signals for cells: those are mechanical signals (coming from the environment or arising from within the body), which have been less known in the literature. The review summarizes new information on the mechanosensitivity of various cells of connective tissue and nervous system. Participation of mechanical stimuli in the regulation of growth, development, differentiation, and functioning of tissues is described. The data focus on bone remodeling, wound healing, neurite growth, and the formation of neural networks. Mechanotransduction, cellular organelles, and mechanosensitive molecules involved in these processes are discussed as well as the role of the extracellular matrix. The importance of mechanical characteristics of cells in the pathogenesis of diseases is highlighted. Finally, the possible role of mechanosensitivity in mediating the physiotherapeutic effects is addressed.