Significant metabolic alterations in the liver were observed in dogs with modeled acute peritonitis. These changes significantly impaired detoxification function of the liver, which was seen from the increase in the titer of toxic products in the early post-surgery period not only in the lymph, but also in the blood plasma. The key pathogenic mechanism leading to acute liver failure is destabilization of cell membrane resulting from LPO, phospholipase activity, and tissue hypoxia. Activation of LPO and increase in phospholipase activity in the liver tissues were observed within 12 h after peritonitis modeling.
В хронических экспериментах на собаках с прогрессирующим каловым перитонитом изучали влияние ремаксола на развитие эндогенной интоксикации и детоксикационную способность печени. Показано, что ремаксол сохраняет резистентность печени к действию продуктов перекисного окисления липидов и активизации фосфолипаз. Высказано предположение о возможности включения ремаксола в перечень лекарственных препаратов, применяемых при остром перитоните с целью поддержания функционального состояния печени.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.