Metabolic Restructuring in the Liver under Conditions of Endogenous Intoxication

Vlasov, A. P.; Kamkina, O. V.; Trofimov, V. A.; Власова, Т. И.; Abramova, Svetlana; Болотских, В. А.

doi:10.1007/s10517-017-3793-z

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…Hydrogen peroxide (H 2 O 2 ) is the end product of the SOD reaction can react in vivo to form the hydroxyl free radical, but H 2 O 2 can only be detoxified by the selenoenzyme, glutathione peroxidase (GP), but not by catalase as the Michaelis constant, which is an inverse measure of enzyme affinity, Km (affinity) of GP, for H 2 O 2 is orders of magnitude lower than for catalase [30][31][32]. Data from the scientific literature on the severity of changes not only in biochemical parameters but also in histomorphological changes of hepatocytes in endotoxicosis of various origins were reported [33,34]. Some authors noted that under such conditions, disruption of superoxide dismutase synthesis may be due to reduced production of transport proteins, in particular ceruloplasmin, but these data certainly require a more detailed study [35].…”

Section: Discussionmentioning

confidence: 99%

Biomarker assessment in urgent surgical pathology of the small bowel: case-control analysis of a retrospective database

O.²,

A.³

et al. 2022

4open

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Background: Small bowel obstruction, mesenteric thrombosis, and strangulated ventral hernia area a challenge in emergency abdominal surgery. This study aimed to evaluate biomarkers of damage to the digestive tract in patients with urgent pathology. Materials and methods: The study involved 71 patients aged 18 to 80 years who were hospitalized in the intensive care unit in the immediate postoperative period. Results: All 71 underwent emergency surgery, 27 with small bowel necrosis. Lactate level area under curve (AUC = 0.964), C-reactive protein (AUC = 0.805) and systolic blood pressure (area under curve, AUC = 0.803) on the context of Sequential Organ Failure Assessment (SOFA) score (AUC = 0.880) showed stratification of patients with complications before surgery. Small bowel necrosis patients revealed an increase in primary thiobarbituric acid (TBA) reactive products (AUC = 0.813) lipid peroxidation products, and a decrease in superoxide dismutase activity (AUC = 0.818) and catalase (AUC = 0.804). Wide variability of intestinal fatty-acid binding protein (I-FABP) from 199.8 to 2189.6 pg/mL were observed in all patients studied, with an AUC = 0.814 in small intestinal necrosis. Conclusion: Surgical pathology of the small intestine due to obstruction of various origina, mesenteric thrombosis, and strangulated ventral hernia pronounced revealed disorders of the antioxidant-prooxidant balance. This was expressed by an increase in lipid peroxidation products, and the level of TBA-reactive products, and the activities of superoxide dismutase (SOD), and catalase. Viewed against the background of an increase in I-FABP above 577 pg/mL, these variables were the most significant indicators of small intestinal necrosis.

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Section: Discussionmentioning

confidence: 99%

Biomarker assessment in urgent surgical pathology of the small bowel: case-control analysis of a retrospective database

O.²,

A.³

et al. 2022

4open

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“…На нашу думку, виявлена динаміка показників антиоксидантної системи у пацієнтів обох груп пов'язана з одного боку із виснаженням компенсаторних можливостей організму за умов розвитку потужного оксидативного стресу, а з іншого -ймовірно, було наслідком негативного впливу продуктів хронічної ендогенної інтоксикації, алкоголю, ацетальдегіду на гепатоцити, де відбуваються процеси детоксикації в організмі хворих з хронічним алкоголізмом та СВА. Останнє підтверджується численними даними наукової літератури щодо виразних змін не лише біохімічних, але і морфологічних показників гепатоцитів [16].…”

Section: рис 3 вміст 8-ізопростану в крові здорових осіб та пацієнтів...unclassified

The Dynamic of Indicators of Lipid Peroxidation and Antioxidant Protection Status in Patients With Polytrauma and Alcohol Withdrawal Syndrome Complicated by Alcohol Delirium

Омельченко-Селюкова¹

2021

RS Global - World Science

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Injuries are one of the leading causes of death and disability in the world. It is known that from 25% to 85% of patients are in a state of alcohol intoxication during hospitalization in the polytrauma department, 5-20% of them develop alcoholic delirium as a complication of alcohol withdrawal.The aim of the study was to analyze the indicators of lipid peroxidation and antioxidant protection in patients with moderate polytrauma and with a state of alcohol withdrawal complicated by alcoholic delirium, depending on the method of sedation. Material and research methods. The study included 80 patients with polysystemic trauma of moderate severity and with a state of alcohol withdrawal complicated by alcoholic delirium. The median age was 45 years [39-54]. Patients in Group 1 (n = 40) were given dexmedetomidine as a sedation method, and in Group 2 (n = 40) they used sedation with diazepam according to the symptom-trigger protocol. The content of the main indicators of the oxidative system was determined in the serum of patients: active products of thiobarbituric acid, diene conjugates, 8-isoprostane to assess the intensity of lipid peroxidation. The state of the antioxidant system was assessed by the content of superoxide dismutase, catalase, glutathione peroxidase. Conclusions. The use of dexmedetomidine for sedation of patients with alcohol withdrawal and alcoholic delirium and polytrauma reduces the manifestations of lipid peroxidation due to faster recovery of enzyme systems of antioxidant protection.

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State of Lipid Synthesis Function of Liver at Moderate Cerebral Ischemia in Newborns From Mothers With Cytomegalovirus Infection

Gorikov¹,

Луценко²,

Ishutina³

2017

Bulletin Physiology and Pathology of Respiration

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Metabolic Restructuring in the Liver under Conditions of Endogenous Intoxication

Cited by 4 publications

References 3 publications

Biomarker assessment in urgent surgical pathology of the small bowel: case-control analysis of a retrospective database

Biomarker assessment in urgent surgical pathology of the small bowel: case-control analysis of a retrospective database

The Dynamic of Indicators of Lipid Peroxidation and Antioxidant Protection Status in Patients With Polytrauma and Alcohol Withdrawal Syndrome Complicated by Alcohol Delirium

State of Lipid Synthesis Function of Liver at Moderate Cerebral Ischemia in Newborns From Mothers With Cytomegalovirus Infection

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