Our study was aimed to identify the types of benign urethral lesions in 92 women of reproductive age. Methods. We performed a physical examination and assessment of the external and internal genitals employing laboratory diagnostic methods, ultrasonography (transvaginal and transperineal scanning), and magnetic resonance imaging (MRI) in all women. Results. Asymptomatic benign benign urethral lesions of the paraurethral region were detected in 22.8% of women. The remaining 2/3 of the patients complained of dysuria and a sensation of a foreign body in the perineum. The most common complaints and clinical manifestations were predominantly observed in the women within one year after childbirth (72.8%). Conclusions. Our findings on the types of benign urethral lesions were 56 urethral diverticula (60.8%) and 34 paraurethral cysts (37.1%). Most such lesions are more likely to occur in the first years after childbirth, so it is necessary to invite women for a pelvic exam during this period. K E y w o r d s-benign urethral lesions, urethral diverticulum, paraurethral cyst, dysuria, dyspareunia.

Objective: to describe a rare case of infective endocarditis (IE) with isolated localization in the pulmonary valve (PV).Materials and methods. We observed primary IE with isolated localization in the PV in a 27-year-old female patient without risk factors of right-side IE.Results. The disease was caused by Streptococcus gordonii and proceeded acutely with typical signs of right-side IE: fever above 38 °С, chills, clinical picture of bilateral septic embolic abscess pneumonia, as well as secondary anemia, secondary thrombocytopenia, and glomerulonephritis. Echocardiography showed large vegetations in the PV prolapsing in the right ventricle and pulmonary artery.Conclusion. IE with localization in the PV should be suspected in patients with fever and clinical picture of septic embolic pneumonia in absence of other embolic situations.

Introduction. Among the most common congenital coagulopathies are haemophilia and Von Willebrand disease. These illnesses are often mimicked by orphan hereditary coagulopathies, including combined coagulation factor V and VIII deficiency.Aim — description of a clinical presentation, hampered diagnosis and choice of haemostatic therapy in a surgical patient with combined blood coagulation factor V and VIII deficiency.Main findings. We describe a clinical case of congenital combined factor V and VIII deficiency and detail the aetiology, frequency, localisation and intensity of haemorrhages. Comorbidity and surgical indications are demonstrated to require an inter-specialty medical involvement.

Цель исследования: изучить влияние единичной трансфузии тромбоцитного концентрата (ТК) на свойства сгустка, образуемого кровью реципиента. Материалы и методы. Обследовано 20 онкогематологических пациентов с тромбоцитопенией (количество тромбоцитов — 20–50×10^9/л), которым проводилась трансфузия ТК с профилактической (n=12) или терапевтической целью (n=8). Качество сгустка у реципиента, количественное определение влияния и количественная характеристика вклада тромбоцитов ТК на качество образуемого сгустка у реципиента оценены различными методиками тромбоэластографии, включая собственные разработки с применением АДФ и разведенных растворов кальция хлорида. Результаты. Показано, что трансфузия ТК приводит к улучшению качества сгустка в целом, но были выявлены различия в составе факторов, обусловивших позитивный результат. После профилактической трансфузии ТК качество сгустка, по-видимому, определяется субпопуляцией агрегатообразующих тромбоцитов. У пациентов с геморрагическими проявлениями для терапевтической трансфузии были использованы ТК с бóльшим содержанием самих тромбоцитов и с бóльшим сроком хранения, что предполагает присутствие бóльшего количества микрочастиц с экспрессированным фосфатидилсерином. Заключение. Предполагается, что вследствие более активной выработки тромбина улучшение качества сгустка происходило преимущественно за счет фибрина, а не тромбоцитов. УДК 616.151.5: 616-00 The aim: to study how single platelet concentrate transfusion (PC) effects on clot properties formed by recipient blood. Materials and methods. Twenty oncohematological patients with thrombocytopenia (platelet count — 20–50×10^9/L) were examined before and after single PC transfusion aimed for hemorrhage prevention (n=12) and for hemorrhage therapy (n=8). Recipient clot quality, quantitative impact and quantitative value of PC-platelets had evaluated by different thromboelastography methods including our own development basing on combination of ADP solutions with diluted solutions of calcium chloride. Results. It was shown that PC transfusion improved generally recipient clot quality but influenced reasons were differed. We assumed that after prophylactic PC transfusion the subpopulation of agregates-forming platelets played main role for the properties of recipient blood clot. In the hemorrhagic cases the therapeutic transfusion was performed by long-storaging PC containing more count of both platelets and microparticles carrying surface-expressed phosphatidylserine. Conclusion. Perhaps, due to more active thrombin generation the recipient clot quality improvement had developed mainly via fibrinogen/fibrin but not via the platelets. UDC 616.151.5: 616-00