The paper studied the effect of microbial polysaccharides on the leukogram of laboratory animals and studied the dynamics of peripheral blood parameters with an assessment of immunobiological reactivity based on established patterns of physiological status. The results of numerous studies of the state of natural resistance of farm animals indicate that protective forces are a dynamic indicator, and is determined both by the genetic characteristics of the body and the impact of various environmental factors. This circumstance allows directionally influencing the formation and manifestation of the body’s defenses. Thus, the study of the immunological reactivity of the organism of farm animals becomes relevant for understanding the pathogenesis of diseases, for rational pathogenetic therapy. The problem of increasing the nonspecific resistance of productive animals has not lost its relevance in the current difficult economic situation in Russia. This fact is dangerous by the manifestation of enzootic outbreaks of infectious diseases and a gradual decrease in the breeding value of animals.
Changes of immunological reactivity to viral and bacterial antigens can cause in-creased susceptibility to infectious diseases. Different levels of this changes in newborn and adult animal organisms should be based on the fetus and newborn reactivity, first coming into contact with the antigen after birth, whereas the adult organism already has partial sensitization. Chronic vectors of pathological agents in animals and their in-fluence on the spread of infectious process is a persisting problem of modern veterinary medicine. The ability to use vaccination in newborns is limited by the presence of maternal antibodies that have immunosuppres-sive effects. High level of functional abilities of preg-nant organism is important in prevention of intrauterine infection. Infection in the prena-tal period of development affects fetal growth and development processes on the one hand, and on the other - isoimmuniza-tion of the maternal organism with fetal anti-gens occurs, accompanied by increased sen-sitivity of the organism with predominant manifestation of cellular phenomena, in the absence of increased synthesis of antibodies. Given the high importance of the functional reserves of the newborn organism, the intra-uterine development and completeness of the placental barrier are important. Detection of the transportation of infectious agent in inac-tive phase during pregnancy of different gestational period should be considered from the point of view of avidity and seropositivi-ty of pregnant animals. The high variety of clinical manifesta-tions of intrauterine infection requires the development of minimally invasive methods of antenatal and intranatal prediction, which allow at the stage of pregnancy and/or child-birth to assess the presence of an agent in a very small amount as the risk of the future development of infectious disease of the fetus and newborn, or complications of the early neonatal period.
Abstracts. Venereology and Dermatology. Histological changes in the skin after the administration of salvarsan. Еhert (D. Z. Bd. 57, N. 4) administered salvarsan solutions intradermally and on incisions on the skin and then examined these areas histologically. It turned out that the changes affect both the epidermis and the skin itself; they are partially inflammatory, proliferative and degenerative in nature up to the onset of pre-cancerous phenomena.
Changes in immunological reactivity to viral and bacterial antigens may cause increased susceptibility to infectious diseases. Different levels of this condition in newborn and adult animal organisms should be based on the fact that the fetus and newborn after birth first comes into contact with the antigen, while the adult body already has partial sensitization. Chronic carrier of pathogens in animals and their influence on the spread of the infectious process is an urgent problem of modern veterinary medicine. The possibility of vaccination in newborns is limited by the presence of maternal antibodies that have an immunosuppressive effect. A high level of functional reserves of the pregnant body is important in the prevention of intrauterine infection. On the one hand, infection in the prenatal period of development affects the processes of growth and development of the fetus, on the other hand, during this period, the mother's body is isoimmunized by fetal antigens, accompanied by increased sensitivity of the body with the predominant manifestation of cellular phenomena in the absence of enhanced antibody synthesis.
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