The study of immunological relationships in the functional system “mother-placenta-offspring” can make a significant contribution to the solution of the issue of improving the safety of the population of newborn animals and poultry. The pathology of the antenatal development of animals has not been sufficiently studied. Antenatal pathology of animals is more often manifested in the form of congenital malformations (anomalies) of development. Congenital defects are usually called those that occur during intrauterine development. However, congenital malformations are also observed in the period of postnatal development – as a consequence of a violation of the further formation of organs in animals. There is a need to develop a method for determining the immunological reactivity of the animal body, which would allow to assess the combined functional state of cell-mediated immunological reactivity of innate and acquired immunity in the functional system “mother-placenta-offspring” and determine the factors that cause immunosuppression. Determination of the immunological reactivity of the animal body includes a blood test by conducting a biological test, which uses the biological activity of red blood cells in the Nitroblue Tetrazolium Test and according to their sorption activity-more than 40% - animals are classified as individuals with reduced immunological reactivity among similar ones.
The paper studied the effect of microbial polysaccharides on the leukogram of laboratory animals and studied the dynamics of peripheral blood parameters with an assessment of immunobiological reactivity based on established patterns of physiological status. The results of numerous studies of the state of natural resistance of farm animals indicate that protective forces are a dynamic indicator, and is determined both by the genetic characteristics of the body and the impact of various environmental factors. This circumstance allows directionally influencing the formation and manifestation of the body’s defenses. Thus, the study of the immunological reactivity of the organism of farm animals becomes relevant for understanding the pathogenesis of diseases, for rational pathogenetic therapy. The problem of increasing the nonspecific resistance of productive animals has not lost its relevance in the current difficult economic situation in Russia. This fact is dangerous by the manifestation of enzootic outbreaks of infectious diseases and a gradual decrease in the breeding value of animals.
It is known that the pathological course of pregnancy is associated with a disturbance in the interdependent “mother-fetus” complex and leads to specific clinical consequences at the molecular-cellular, tissue, organ, organismal and population levels of organization. In case of violation of placentation (placental barrier), a state of immune conflict occurs, characterized by an antigen-antibody reaction, carried out through the placenta (in relation to the fetus), or through colostrum after birth (in relation to the newborn offspring). Therefore, immunological relations at the population level should be considered both the consequences of the action of the maternal organism’s antigens on the fetus, and the effects of the allogeneic action of the fetus on the mother’s body. According to the results of the experiment, the placentas of 10 sows of Large White breed were used as the material, which showed signs of isoimmunization to the resulting offspring. For histological examination, immediately after delivery, pieces of placenta up to 0.5 cm thick were selected, which were fixed in a 10% aqueous solution of neutral formalin. The fixed material after wiring through alcohols of increasing concentration, xylene, xylene-paraffin, was poured into paraffin. The obtained preparations were stained with conventional methods-hematoxylin and eosin. d (fibrinoid masses).
Changes of immunological reactivity to viral and bacterial antigens can cause in-creased susceptibility to infectious diseases. Different levels of this changes in newborn and adult animal organisms should be based on the fetus and newborn reactivity, first coming into contact with the antigen after birth, whereas the adult organism already has partial sensitization. Chronic vectors of pathological agents in animals and their in-fluence on the spread of infectious process is a persisting problem of modern veterinary medicine. The ability to use vaccination in newborns is limited by the presence of maternal antibodies that have immunosuppres-sive effects. High level of functional abilities of preg-nant organism is important in prevention of intrauterine infection. Infection in the prena-tal period of development affects fetal growth and development processes on the one hand, and on the other - isoimmuniza-tion of the maternal organism with fetal anti-gens occurs, accompanied by increased sen-sitivity of the organism with predominant manifestation of cellular phenomena, in the absence of increased synthesis of antibodies. Given the high importance of the functional reserves of the newborn organism, the intra-uterine development and completeness of the placental barrier are important. Detection of the transportation of infectious agent in inac-tive phase during pregnancy of different gestational period should be considered from the point of view of avidity and seropositivi-ty of pregnant animals. The high variety of clinical manifesta-tions of intrauterine infection requires the development of minimally invasive methods of antenatal and intranatal prediction, which allow at the stage of pregnancy and/or child-birth to assess the presence of an agent in a very small amount as the risk of the future development of infectious disease of the fetus and newborn, or complications of the early neonatal period.
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