Inflammatory MRI lesions in early AS are seen more often in posterior structures of the spine. This may be relevant for the diagnosis of early AS and the early detection of inflammatory spinal involvement.
Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patient with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a 2-year randomized trial.
Контакты: Анна Георгиевна Бочкова botchkova@inbox.ru
Цель. Получение собственного опыта терапии адалимумабом (АДА) у больных анкилозирующим спондилитом (АС), а также уточнение влияния АДА на определяемые при магнитно-резонансной томографии (МРТ) воспалительные изменения (ВИ) в позво-ночнике и энтезисах пяток при краткосрочном использовании данного генно-инженерного биологического препарата (ГИБП).
Материал и методы. В открытое наблюдение включено 14 пациентов с определенным в соответствии с модифицированными
Objective: To gain experience with adalimumab therapy in patients with ankylosing spondylitis (AS) and to clarify the effect of the drug on MRI-detectable inflammatory changes (IC) in the vertebral column and heel enthesis with the short-term use of this gene engineering biological.
Subjects and methods. This open-label observation included 14 patients diagnosed as having AS in accordance with the modified New York criteria [4] and 3 patients with early undifferentiated spondyloarthritis (uSA). The ESSG criteria were used for the diagnosis of uSA. In addition to the BASDAI index, the new international index for disease activity in AS (ASDAS) proposed by the ASAS group in 2009 was first employed to assess the activity of AS. MRI-detectable IC in the thoracic spine, sacroiliac articulation, AND heel bones (in patients with
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