The First Experience in Using Adalimumab in Patients With Ankylosing Spondylitis: Clinical and Mricomparisons of the Results of Therapy

Abstract

Контакты: Анна Георгиевна Бочкова botchkova@inbox.ru Цель. Получение собственного опыта терапии адалимумабом (АДА) у больных анкилозирующим спондилитом (АС), а также уточнение влияния АДА на определяемые при магнитно-резонансной томографии (МРТ) воспалительные изменения (ВИ) в позво-ночнике и энтезисах пяток при краткосрочном использовании данного генно-инженерного биологического препарата (ГИБП). Материал и методы. В открытое наблюдение включено 14 пациентов с определенным в соответствии с модифицированными Objective: To gain experience with adalimumab therapy in patients with ankylosing spondylitis (AS) and to clarify the effect of the drug on MRI-detectable inflammatory changes (IC) in the vertebral column and heel enthesis with the short-term use of this gene engineering biological. Subjects and methods. This open-label observation included 14 patients diagnosed as having AS in accordance with the modified New York criteria [4] and 3 patients with early undifferentiated spondyloarthritis (uSA). The ESSG criteria were used for the diagnosis of uSA. In addition to the BASDAI index, the new international index for disease activity in AS (ASDAS) proposed by the ASAS group in 2009 was first employed to assess the activity of AS. MRI-detectable IC in the thoracic spine, sacroiliac articulation, AND heel bones (in patients with

Clinical and functional characteristics of the cardiovascular system involvement in various variants of ankylosing spondylitis

“…The radiological stage of the disease was determined (by Steinbroker) by the radiography of the pelvic and spine bones. All patients underwent echocardiographic (ECHOX) examination on the MEDISON 8000 LIGHT ultrasound diagnostic apparatus (South Korea) with a 2.4 mHz cardiac sensor in accordance with the recommendations of the American Association of Echocardiography, in one-dimensional and two-dimensional mode in standard echocardiographic positions [13].…”

“…formula. Teichholtz et al [13]. In order to assess the diastolic filling of the left ventricle, a transmitral flow was recorded.…”

TUMOR NECROSIS FACTOR-α INHIBITORS IN THE TREATMENT OF AXIAL SPONDYLOARTHRITIS, INCLUDING ANKYLOSING SPONDYLITIS

“…Имеются данные об улучшении функциональных возможностей у больных АС даже при полном анкилозе позвоночника. Было показано, что иФНОα хорошо подавля-ют внутрикостное воспаление, выявляемое при магнитно-резонансной томографии (МРТ) на ранних стадиях [22][23][24][25][26].…”