Spinal inflammation lesions as detected by magnetic resonance imaging in patients with early ankylosing spondylitis are more often observed in posterior structures of the spine

Бочкова, А. Г.; Левшакова, А. В.; Бунчук, Н В; Braun, Jürgen

doi:10.1093/rheumatology/kep419

Cited by 50 publications

(17 citation statements)

References 18 publications

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“…The 17% positive patients at baseline in our study are different from previous reports, which found inflammation at this site in a higher percentage of patients 38 39…”

Section: Discussioncontrasting

confidence: 99%

Effects of etanercept versus sulfasalazine in early axial spondyloarthritis on active inflammatory lesions as detected by whole-body MRI (ESTHER): a 48-week randomised controlled trial

et al. 2011

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PurposeTo evaluate the potential of etanercept versus sulfasalazine to reduce active inflammatory lesions on whole-body MRI in active axial spondyloarthritis with a symptom duration of less than 5 years.MethodsPatients were randomly assigned to etanercept (n=40) or sulfasalazine (n=36) treatment over 48 weeks. All patients showed active inflammatory lesions (bone marrow oedema) on MRI in either the sacroiliac joints or the spine. MRI was performed at weeks 0, 24 and 48 and was scored for active inflammatory lesions in sacroiliac joints and the spine including posterior segments and peripheral enthesitis by two radiologists, blinded for treatment arm and MRI time point.ResultsIn the etanercept group, the reduction of the sacroiliac joint score from 7.7 at baseline to 2.0 at week 48 was significantly (p=0.02) larger compared with the sulfasalazine group from 5.4 at baseline to 3.5 at week 48. A similar difference in the reduction of inflammation was found in the spine from 2.2 to 1.0 in the etanercept group versus from 1.4 to 1.3 in the sulfasalazine group between baseline and week 48, respectively (p=0.01). The number of enthesitic sites also improved significantly from 26 to 11 in the etanercept group versus 24 to 26 in the sulfasalazine group (p=0.04 for difference). 50% of patients reached clinical remission in the etanercept group versus 19% in the sulfasalazine group at week 48.ConclusionIn patients with early axial spondyloarthritis active inflammatory lesions detected by whole-body MRI improved significantly more in etanercept versus sulfasalazine-treated patients. This effect correlated with a good clinical response in the etanercept group.

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“…The 17% positive patients at baseline in our study are different from previous reports, which found inflammation at this site in a higher percentage of patients 38 39…”

Section: Discussioncontrasting

confidence: 99%

Effects of etanercept versus sulfasalazine in early axial spondyloarthritis on active inflammatory lesions as detected by whole-body MRI (ESTHER): a 48-week randomised controlled trial

et al. 2011

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“…In established AS with longer disease duration, involvement of posterior elements was described in up to 87% of patients affected 32. Our findings are in contrast to a recent publication by Bochkova et al ,33 where much higher frequencies of posterior element involvement, especially in cases of early SpA, was reported (figure 2). …”

Section: Discussioncontrasting

confidence: 95%

Active inflammation and structural change in early active axial spondyloarthritis as detected by whole-body MRI

et al. 2012

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“…recently demonstrated that about half of their 27 patients with non‐radiographic SpA had evidence of erosions in the sacroiliac joints on MRI. Bochkova et al . recently found that AS patients with short disease duration had frequent involvement of the posterior elements of the spine compared to the vertebral bodies.…”

Section: Diagnostic Criteriamentioning

confidence: 99%

Update on biologic therapies in ankylosing spondylitis: a literature review

Goh

Samanta

2012

Int J of Rheum Dis

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Spinal inflammation lesions as detected by magnetic resonance imaging in patients with early ankylosing spondylitis are more often observed in posterior structures of the spine

Abstract: Inflammatory MRI lesions in early AS are seen more often in posterior structures of the spine. This may be relevant for the diagnosis of early AS and the early detection of inflammatory spinal involvement.

Cited by 50 publications

References 18 publications

Effects of etanercept versus sulfasalazine in early axial spondyloarthritis on active inflammatory lesions as detected by whole-body MRI (ESTHER): a 48-week randomised controlled trial

Effects of etanercept versus sulfasalazine in early axial spondyloarthritis on active inflammatory lesions as detected by whole-body MRI (ESTHER): a 48-week randomised controlled trial

Active inflammation and structural change in early active axial spondyloarthritis as detected by whole-body MRI

Update on biologic therapies in ankylosing spondylitis: a literature review

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