Аннотация. Статья посвящена оценке качества молочной консервной продукции, востребованной потребителями и занимающей определенное место в потребительской корзине. Ассортимент молочных консервов широк и разнообразен, в связи с чем продукция должна быть привлекательна не только по ценовой категории, но и отвечать требованиям качества и потребительской оценке. В качестве образцов выбраны консервы молочные сгущенные с сахаром различных производителей, представленные на потребительском рынке г. Кемерово. При выполнении исследований применяли органолептические и квалиметрические методы анализа. Определение состояния упаковки и маркировки проводили в соответствии с требованиями действующих нормативных документов ТР ТС 022/2011, ТР ТС 005/2011. Показатели качества образцов определяли в соответствии с ГОСТ 31688-2012 и ТР ТС 033/2013. Сенсорную оценку образцов проводили по разработанной 25-балловой шкале. В работе приведены результаты оценки потребительских свойств выбранных объектов, отмечены достоинства и недостатки упаковки и маркировки объектов, представлены результаты ранжирования молочных консервов методом дескрипторно-профильного анализа, когда объекты экспертизы представлены в порядке снижения сенсорных характеристик. Рассматривали итоговое определение степени предпочтения дегустаторами по результатам сенсорной оценки образцов. Выявили сходство и различия между образцами в соответствии с выставленными баллами. Потребительские свойства характеризовали эргономические и эстетические показатели упаковки и маркировки образцов. Полученные результаты могут представлять интерес для перерабатывающих молочных предприятий при установлении категории качества и для торговых организаций при формировании ассортимента молочных консервов.
Proton and carbon beam therapy is currently recognized as the most effective and highly accurate form of radiation therapy for deeply located tumors, including radioresistant ones. This is due to the fact that they have all the advantages of spatial dose distribution and, at the same time, are densely ionizing radiations capable of effectively affecting hypoxic, slow growing tumors and other neoplasms that are insensitive to traditional types of radiation. It is well known that one of the main methods for treating neoplasms is chemotherapy. The predominant mechanism of action of anti tumor drugs is the induction of DNA damage with the subsequent impossibility of repair. In our study, we used an anti tumor antibiotic of the anthracycline series, doxorubicin. The assessment of the potential significance of the synergistic interaction of ionizing radiation with chemical preparations in medical radiology remains an urgent and unresolved problem. It is possible to achieve the maximum effect of the combined action of two agents when they act simultaneously. The phenomenon of synergy can be used to optimize the combined use of radiation and chemotherapy in clinical practice. In this regard, it seems relevant to conduct a study for HeLa cancer cells exposed to ionizing radiation, an antitumor drug, as well as their combination. In the course of the study, results were obtained on the manifestation of the synergistic nature of the agents used, which is of great practical and theoretical importance for understanding the mechanism of the combined effect of ionizing radiation and the chemotherapy drug (doxorubicin). The obtained data can be helpful in optimizing the combined effects in order to achieve maximum synergistic interaction.
According to the American Thyroid Association’s 2015 guidelines: “Since hyperfunctioning nodules rarely harbor malignancy, if one is found that corresponds to the nodule in question, no cytologic evaluation is necessary”. These findings are based on numerous studies proving the rareness of the combination of functional autonomy and thyroid cancer, and when such casuistry is detected, the non-aggressive course of the malignant process is observed.Rare revealing of malignant nodules functional autonomy can be attributed to several fundamental bases of non-medullary thyroid carcinoma pathogenesis. According to one of the hypotheses of carcinogenesis, dedifferentiation of thyrocytes occurs initially with the loss of the possibility of the sodium-iodine symporter synthesis, and later of the thyroid-stimulating hormone receptor synthesis by the cell, which reduces the hormone production by tumor cells. In addition, hyperthyroidism has a protective feature. It reduces the level of thyroid-stimulating hormone (which causes hypertrophy, hyperplasia of thyrocytes and has an antiapoptotic effect). This protective function is used in practice for suppressive therapy in the postoperative period, which reduces the progression, recurrence and mortality from thyroid cancer. The above circumstances prove the rareness of the clinical observation described below, which deserves additional attention and subsequent discussion.
The purpose of this work was to study the nature of the combined effect of ionizing radiation of accelerated 12C ions with the antitumor agent doxorubicin on malignant cells. In the course of the research, new results were obtained on the manifestation of the synergistic character of the interaction of the agents used on the cells of the MCF-7 tumor line, which is of important practical and theoretical significance for understanding the mechanism of the combined effect of ionizing radiation and the chemotherapy drug doxorubicin. The obtained data will help to optimize the combined effects in order to achieve maximum synergistic interaction.
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