Investigation of the Combined Effect of Ionizing Radiation of Different Quality and Doxorubicin on Breast Adenocarcinoma Cells

Abstract

The purpose of this work was to study the nature of the combined effect of ionizing radiation of accelerated 12C ions with the antitumor agent doxorubicin on malignant cells. In the course of the research, new results were obtained on the manifestation of the synergistic character of the interaction of the agents used on the cells of the MCF-7 tumor line, which is of important practical and theoretical significance for understanding the mechanism of the combined effect of ionizing radiation and the chemotherapy drug doxorubicin. The obtained data will help to optimize the combined effects in order to achieve maximum synergistic interaction.