Objective.Primary hyperaldosteronism (PGA) (Conn’s syndrome) is a relatively rare phenomenon in therapeutic practice, occurring in 4,7–9%. In resistant hypertension (HTN) the rate of PGA achieves 10–20%. Often it results from the aldosterone-producing adrenal tumors and manifests by symptomatic HTN, neuromuscular, and renal symptoms. We present the cases of successful verification and surgical treatment of PGA. HTN patients and patients with rhabdomyolysis symptoms (increased creatine phosphokinase or lactate dehydrogenase) require further examination to exclude PGA.
Aim. To evaluate the morphological and functional parameters of the myocardium in patients with coronary artery disease (CAD) and concurrent overt primary hypothyroidism, as well as to identify possible relationships between these parameters and levels of thyroid hormones.Methods. 344 patients with CAD who had verified classes 1-3 stable angina pectoris using the clinical guidelines were recruited in a study [6]. 100 patients with CAD and concurrent primary hypothyroidism were enrolled in the study group. 244 patients with CAD were enrolled in the comparison group. Severity of stenosis in one- and/ or two- and/or three-vessel disease were measured in all patients. A comparative assessment of biochemical parameters and echocardiography was performed. A single-stage cross-sectional comparative analysis of the studied parameters was performed. The presence of any relationships of thyroid hormones with morphological and functional parameters of the myocardium were determined. The correlation analysis reported the relationships between diastolic dysfunction, left ventricular ejection fraction and thyroid-stimulating hormone levels in patients with CAD and concurrent hypothyroidism.Results. Statistically significant differences in lipid profile, glucose levels, glycated hemoglobin, and glomerular filtration rate were found. Three-vessel disease prevailed in both groups, but the prevalence of three-vessel disease was higher in the study group (CAD and hypothyroidism) than in the comparison group (p<0.01). Echocardiography assessment reported the differences in the levels of E/a (p = 0.02), E/E` (p = 0.001), and LVEF (p = 0.001) between the study groups.Conclusion. Patients with coronary artery disease and concurrent overt primary hypothyroidism demonstrated worse dyslipidemia parameters, glycemic indicators and impaired glomerular filtration rate. Three-vessel disease prevailed among patients enrolled in the study. The relationship between TSH and myocardial morphological and functional parameters was determined. Obtained data can be used for assessing the prognosis in this group of patients.
ФГБОУ ВО "Иркутский государственный медицинский университет" Минздрава России. Иркутск, Россия Цель. Обосновать возможность использования данных, полученных в центрах здоровья (ЦЗ) Иркутской области, для мониторинга факторов риска (ФР) сердечно-сосудистых заболеваний (ССЗ). Материал и методы. Из 9 ЦЗ Иркутской области ретроспективно были проанализированы 3374 карты ЦЗ пациентов в возрасте 25-64 лет за 2010-2012гг, отобранные случайным способом. Оценивались основные ФР ССЗ. Результаты были представлены в виде медианы (Ме [LQ; UQ]), процентов (%), критерия χ 2 , разница оценивалась как статистически значимая при p<0,05. Результаты. Соотношение женщин и мужчин 25-64 лет в структуре посещаемости ЦЗ ИО составило 4,1:1, в то время как в популяции Иркутской области-1,15:1, также были различия в распределении по возрастным группам. Распространенность гиперхолестеринемии; избыточного потребления соли; недостаточного потребления овощей и фруктов; недостаточной физической активности; повышенного артериального давления; ожирения; курения; избыточного потребления алкоголя у женщин, мужчин и общая стандартизиро
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