Возвратный гортанный нерв может иметь множество анатомических вариантов при экстраларингеальном расположении, что нередко приводит к смене техники оперативного вмешательства в каждом конкретном случае. В статье описаны два клинических наблюдения выявления невозвращающегося возвратного гортанного нерва и дополнительных коллатеральных анастомозирующих структур возвратного гортанного нерва. Невозвращающий-ся возвратный гортанный нерв, по данным последних исследований, встречается в общей популяции несколько чаще (до 4,8%), чем может предположить практикующий хирург-эндокринолог. Выявление невозвращающегося возвратного гортанного нерва перед операцией является важным объектом исследований. По данным многих авторов, парезы гортани при невозвращающемся возвратном гортанном нерве увеличиваются в разы по сравнению с возвращающимся гортанным нервом. Функциональное и клиническое значение анастомозирующих структур возвратного гортанного нерва до сих пор остается неизвестным. Визуализация их во время операции -редкое явление. Это приводит к их неизбежному повреждению. Таким образом, альтернативой теории тракционных повреждений возвратного гортанного нерва мы видим повреждение его нестандартных анатомических вариантов и анастомозирующих структур. В связи с редкостью выявления таких вариантов экстраларингеального расположения возвратного гортанного нерва считаем целесообразным поделиться собственным опытом. Ключевые слова: невозвращающийся возвратный гортанный нерв, анастомоз Галена, симпатическая анастомозирующая ветвь нижнего гортанного нерва, клиническое наблюдение.The recurrent laryngeal nerve can have a variety of options in extralaryngeal position, which often changes the technique of surgical intervention in each specific case. Below there are two clinical observations of the non-recurrent laryngeal nerve and additional collateral anastomosing structures of the recurrent laryngeal nerve. The non-recurrent laryngeal nerve, according to the recent research, is found in the general population somewhat more often (up to 4.8%) than the practicing surgeon may suggest. The identification of a non-recurrent laryngeal nerve before surgery is an important object of research. According to many authors, the cord palsy in the non-recurrent laryngeal nerve increases many times compared with the recurrent laryngeal nerve. The functional and clinical significance of the anastomosing structures of the recurrent laryngeal nerve is still unknown. To visualize them during surgery is a rare phenomenon, which ultimately leads to their damage. Thus, an alternative to the theory of traction damage of the recurrent laryngeal nerve is the damage to its non-standard anatomical variants and anastomosing structures. Taking into account that such an option of extralaryngeal location of the recurrent laryngeal nerve is so rare, we consider it appropriate to share our own experience.
Hypoparathyroidism is the most common complication after surgery on the thyroid gland. All authors confirm the fact that the main cause of hypoparathyroidism is a violation of the blood supply of parathyroid glands, as well as their damage or even accidental removal during surgery. Having analyzed the real cases, and based on our own experience, we came to the conclusion that in order to prevent complications, we will need to study the types of blood supply of the parathyroid glands in details. To this end, we have performed 46 unilateral microdissections and X-ray angiography studies of the arterial supply at 23 organocomplexes of the neck. 42 upper and 43 lower parathyroid glands were detected. It has been established that the main feeding vessel of parathyroid glands is the inferior thyroid artery (type I). The association of glands with the inferior thyroid artery was revealed in 71.8% of cases. A mixed variant of blood supply (simultaneously from the superior and inferior thyroid arteries) was revealed in 14.1% cases (type II). Only 10.6% of the gland were fed isolated from the superior thyroid artery (type III). In addition, in 8.7% cases in the preparations there was no inferior thyroid artery. In 3.5% cases, the connections of the lower parathyroid glands with the thyroid arteries were not reliably detected. Most probably, their feeding was provided at the expense of small collaterals from surrounding organs (type VI).
Background. The thesis «thyroid surgery is the surgery of the recurrent laryngeal nerve», which was defined in the XX century, remains relevant to this day. Thus, despite the use of modern scientific and technological achievements, vocal cord paresis is diagnosed on average in 9.8% patients after thyroid and parathyroid surgery.According to many authors, the main problem which a surgeon encounters is a difficult and sometimes individual anatomy of the recurrent laryngeal nerve. For example, in one study authors identified 28 variants of relationships between the recurrent laryngeal nerve and the inferior thyroid artery. In a recent meta-analysis, it was noted that the frequency of extralaryngeal branching remains underestimated and reaches 73% of cases. Anatomical variants of the recurrent laryngeal nerve or its thin branches, which have not been noticed in time, can lead to inevitable consequences — to nerve injury and a laryngeal dysfunctions, and if anatomical features are not detected on both sides — to a tragedy.Aim. The aim of this study is to determine anatomical variants of the extralaryngeal branches of the recurrent laryngeal nerve and their frequency in autopsy case series.Materials and methods. 46 (100%) recurrent laryngeal nerves were dissected in 23 cadavers. Their path was traced, their relationships with the inferior thyroid artery were determined, and the extralaryngeal branches of the recurrent laryngeal nerve were identified.Results. Few extralaryngeal branches of the recurrent laryngeal nerve were identified during dissection: tracheoesophageal branches, laryngeal branches, aberrant branches. Tracheoesophageal branches were determined in all cadavers. In 37 (80.4%) cases the recurrent laryngeal nerve had got two or more extralaryngeal laryngeal branches. In 6 (13.0%) cases aberrant branches were presented.The inferior thyroid artery was detected in 42 (91.3%) cases. The vessel was in close location with the recurrent laryngeal nerve, forming a neuro-arterial chiasm. In 39.1% of cases the recurrent laryngeal nerve was located between the branches of the inferior thyroid artery, in 39.1% of cases — deeper than the artery, and in 10.9% of cases — more superficial than the artery.Conclusion. The variable anatomical configuration of the recurrent laryngeal nerve inevitably causes difficulties during intraoperative nerve dissection. Tardy identification of these anatomical features can lead to the injury of nerves or its branches, which determines the amount of postoperative vocal cord paresis.
Background. The external branch of the superior laryngeal nerve innervates a cricothyroid muscle, which provides tension in vocal cords and formation of high-frequency sounds. When the nerve is damaged during surgery, patients may notice hoarseness, inability to utter high pitched sounds, “rapid fatigue” of the voice, and dysphagia. According to literature, paresis of an external branch of the superior laryngeal nerve reaches up to 58% after thyroid surgery. Aim: to identify permanent landmarks and topographic variations of the external branch of the superior laryngeal nerve. Materials and methods. The study is based on the autopsy material (21 complexes organs of the neck) and on identification of variations of 40 external branches of the superior laryngeal nerve. We identified two permanent landmarks that are located at the minimum distance from nerve and we made metrical calculations relative to them: oblique line of thyroid cartilage and tendinous arch of the inferior pharyngeal constrictor muscle. Results. The piercing point of the nerve is always located at the inferior pharyngeal constrictor muscle without protruding beyond the oblique line of thyroid cartilage superiorly and tendinous arch of the inferior pharyngeal constrictor muscle anteriorly. The nerve had the parallel direction in 92.8% of cases (angel less than 30 degrees) relative to the oblique line and in 85.7% cases it was in close proximity to this line (at distance up to 4 mm). The proposed topographic classification of the location of the external branch of the superior laryngeal nerve is based on localization of the piercing point of the nerve relative to the length of the oblique line of thyroid cartilage and the risk of nerve damage. In 14.2% of cases, the piercing point was in the front third of the line (type I), and in 50% it was in the middle third of this line (type II). These variations of the external branch of the superior laryngeal nerve was in close proximity to the upper pole of the thyroid gland, which could have lead to its damage during surgery. In type III and IV (35.8%) – the piercing point in the muscle was located as far as possible from the upper pole of the thyroid gland and the greater part of the nerve was covered with the fibers of inferior pharyngeal constrictor muscle. Conclusion. We identified the main orienteers for the search and proposed anatomical classification of the location of the external branch on the superior laryngeal nerve.
According to the American Thyroid Association’s 2015 guidelines: “Since hyperfunctioning nodules rarely harbor malignancy, if one is found that corresponds to the nodule in question, no cytologic evaluation is necessary”. These findings are based on numerous studies proving the rareness of the combination of functional autonomy and thyroid cancer, and when such casuistry is detected, the non-aggressive course of the malignant process is observed.Rare revealing of malignant nodules functional autonomy can be attributed to several fundamental bases of non-medullary thyroid carcinoma pathogenesis. According to one of the hypotheses of carcinogenesis, dedifferentiation of thyrocytes occurs initially with the loss of the possibility of the sodium-iodine symporter synthesis, and later of the thyroid-stimulating hormone receptor synthesis by the cell, which reduces the hormone production by tumor cells. In addition, hyperthyroidism has a protective feature. It reduces the level of thyroid-stimulating hormone (which causes hypertrophy, hyperplasia of thyrocytes and has an antiapoptotic effect). This protective function is used in practice for suppressive therapy in the postoperative period, which reduces the progression, recurrence and mortality from thyroid cancer. The above circumstances prove the rareness of the clinical observation described below, which deserves additional attention and subsequent discussion.
BACKGROUND. Current trends of «fast track surgery» give rise to development of new safe techniques of the thyroid and parathyroid surgery, the purpose of which is to minimize the level of postoperative complications, such as vocal cord palsy, hypoparathyroidism, bleeding. In this regard, it is important for the endocrine surgeon to save «dry operating field», which contributes to the clear visualization of such «thin» structures as the recurrent laryngeal nerve, the external branch of the superior laryngeal nerve and the parathyroid glands. Therefore, the key issue of this surgery is to understand the anatomical and topographic features of the blood supply to the internal neck organs (a complex of neck organs consisting of the thyroid and parathyroid glands, larynx, trachea, esophagus).AIM. To determine the main sources of arterial blood supply of the internal neck organs and their anatomical, topographic features.MATERIALS AND METHODS. The computed tomography protocols of cervical branches of brachiocephalic arteries were analysed in the study. The thickness of the reconstructed sections in the axial, frontal and sagittal planes was 0.35±0.05 mm. The fact of blood supply was confirmed by the anatomical close of the arterial structure to the internal organ and the presence of intramural arterial branches.RESULTS. The course of all cervical branches of the subclavian and common carotid artery was traced among 42 patients. It is noted, that only the inferior, superior thyroid arteries and thyroid ima artery supply internal neck organs with the blood. At the same time, the superior thyroid artery was visualized in all angiograms. However, the inferior thyroid artery was absent in 2.4% of cases. The thyroid ima artery was rarely detected (in 4.8% of patients). In 73.2% of cases, the inferior thyroid artery was detected high at the upper third level of the thyroid lobe and then had a descending course. In 23.2% of cases, the artery was formed at the middle third level of the thyroid lobe and was directed horizontally to the gland. Only in 3.6% of cases, the ascending course was determined in the vessel. The inferior thyroid artery was located on the posterior surface of the thyroid lobe, where it formed glandular branches. On the contrary, the branches of the superior thyroid artery were located mainly along the anterolateral surface of the thyroid gland. The average thickness of the inferior thyroid artery was 2.1±0.5 mm, and the superior thyroid artery was 1.6± 0.7 mm.CONCLUSION. According to the study, arterial blood supply to the internal neck organs is provided mainly by the inferior and superior thyroid arteries. At the same time, the trunk of the inferior thyroid artery is larger than the superior thyroid artery (p=0.032). The inferior thyroid artery forms branches along the posterior surface of the thyroid lobe and from a topographic point of view it is the main source of blood supply to the parathyroid glands. In most cases, the inferior thyroid artery has a descending course, is directed along the posterior surface of the thyroid gland and forms an X-shaped intersection with the recurrent laryngeal nerve.
Клинический случай: пациентка 31 года без эндокринной патологии в анамнезе с 16 недели четвер- той самопроизвольной беременности начала предъявлять жалобы на выраженные головные боли, затем развились диплопия и правосторонний птоз, а также присоединились тошнота и рвота. По данным МРТ выявлено объемное образование хиазмально-селлярной области 30*19*14 мм (фронтальный* вертикаль- ный* сагиттальный) с супра-латеро-селлярным ростом, деформирующим и смещающим хиазму зрительных нервов; признаки пансинусита, патологического содержимого сосцевидного отростка справа, сосудистой мальформации в правой височной доле. По данным гормонального обследования выявлено снижение содержания ТТГ (0,238 мМЕ/мл), свободного Т4 (3,08 пмоль/л), свободного Т3 (2,78 пмоль/л) и кортизола (18 нмоль/л) – диагностирован гипопитуитаризм и назначена соответствующая заместительная терапия, однако клинические проявления надпочечниковой недостаточности купировались при введении супрафи- зиологических доз глюкокортикостероидов (до 30 мг/сут преднизолона). По поводу гнойного пансинусита, осложненного вторичным менингоэнцефалитом с образованием абсцесса левой лобной доли пациентке проводились повторные хирургические вмешательства, получала антибактериальную терапию. Несмотря на достигнутую санацию пазух и абсцесса лобной доли, состояние оставалось тяжелым: сохранялись го- ловные боли, наблюдалось прогрессирующее снижение зрения (двусторонний амавроз) и двусторонний птоз. Также отмечалась полиурия до 6-9 л/сут без гипернатриемии или снижения удельного веса мочи. Однократный прием десмопрессина в дозе 30 мкг спровоцировал резкое сокращение диуреза и раз- витие гипонатриемии до 124 ммоль/л, купировавшейся самостоятельно, но низко-нормальные значения содержания натрия (130-135 ммоль/л), калия (3,6-4,3 ммоль/л) и глюкозы (3,5-4,1 ммоль/л) сохранялись в дальнейшем. МРТ в динамике (каждые 2 недели) демонстрировала неожиданно выраженный рост об- разования гипофиза с инвазией в оба кавернозных синуса: 47*21*18 мм - 60*24*21 мм (фронтальный* вертикальный*сагиттальный*). Диагноз аденомы гипофиза был сомнителен, предполагалось наличие гипофизита или образования хиазмально-селлярной области иной этиологии – для уточнения диагноза проведена биопсия гипофиза. На основании гистологического и иммуногистохимического исследования диагностирована экстранодальная Т/NK-клеточная лимфома (Ki-67 до 90%), на 23 неделе беременности по жизненным показаниям проведено кесарево сечение для инициации химиотерапии. Данный клинический случай демонстрирует трудности дифференциальной диагностики редко встреча- ющейся экстранодальной Т/NK-клеточной лимфомы с поражением ЦНС и гипофиза у беременной женщины с гипопитуитаризмом и атрофией зрительных нервов. Быстрый рост образования гипофиза с преимуще- ственным увеличением фронтального размера не характерен для аденом гипофиза и/или гипофизита, в связи с чем следует исключить наличие злокачественного процесса.
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