Venous leg ulcers represent a significant public health problem that will increase as the population ages. Numerous herbs and their extracts are potentially conducive to wound healing, including the ability to serve as an antimicrobial, antifungal, astringent, etc. A total of 32 patients with venous leg ulcers were randomized into two groups: a group with herbal therapy treatment (PT) (17 patients) and a control group (C) (15 patients). The investigation focused on five controls of parameter changes important for ulcer healing and the control of microbiological flora. Within-treatment analysis of the PT group showed that, following herbal therapy treatment, there was a significant decrease in the scores of surface leg ulcer and venous leg ulcer after week 7 of treatment (p < 0.05). In group C following topical antibiotic treatment there was no significant decrease in the surface leg ulcer. Comparing the results of decreased venous leg ulcer surface of the) PT group with the C group showed a significant difference at p < 0.05 after week 7 of treatment. The number of different types of isolated bacterial species decreased significantly (p < 0.05) after the use of herbal preparations. The results of this pilot study demonstrate the healing and antimicrobiological effects of herbal therapy on non-infected venous leg ulcer.

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Introduction: Venous leg ulcers are an important and common health problem. The aim of this study was to determine the effects of herbal therapies alone or in combination with physical therapy in the treatment of venous ulcers, as well as their antibacterial effects. Patients and Methods: Our study included 60 patients (3 groups, 20 patients each) with non-infected venous leg ulcers. The patients were treated with herbal therapy alone (group HTC), with a combination of electro-ionizing radiation and herbal therapy (group ERHT) or with a combination of polarized light and herbal therapy (group PLHT). Results: Surface area and score of venous leg ulcers were followed clinically at baseline and at the end of 1, 3, 5, and 7 weeks of treatment. Comparing the results within the HTC, PLHT, and ERHT groups we found that the physical agents and herbal therapy significantly accelerated the healing of venous leg ulcers and reduced bacterial flora (p < 0.05). Comparing the results between the tested groups revealed no statistically significant difference (p > 0.05). Conclusions: Our results demonstrate healing and antibacterial effects of combined physical and herbal therapies, but no superiority of the combined treatment for venous leg ulcers as compared to treatment by herbal therapy alone.

The future of medicine belongs to immunology and alergology. I tried to not be too wide in description, but on the other hand to mention the most important concepts of alergology to make access to these diseases more understandable, logical and more useful for our patients, that without complex pathophysiology and mechanism of immune reaction,we gain some basic insight into immunological principles. The name allergy to medicine was introduced by Pirquet in 1906, and is of Greek origin (allos-other + ergon-act; different reaction), essentially representing the reaction of an organism to a substance that has already been in contact with it, and manifested as a specific response thatmanifests as either a heightened reaction, a hypersensitivity, or as a reduced reaction immunity. Synonyms for hypersensitivity are: altered reactivity, reaction, hypersensitivity. The word sensitization comes from the Latin (sensibilitas, atis, f.), which means sensibility,sensitivity, and has retained that meaning in medical vocabulary, while in immunology and allergology this term implies the creation of hypersensitivity to an antigen. Antigen comes from the Greek words, anti-anti + genos-genus, the opposite, anti-substance substance that causes the body to produce antibodies.

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