Can You Combine Herbal Therapy with Physical Agents in the Treatment of Venous Leg Ulcers?

Janković, Aleksandar; Binić, Ivana; Vrućinić, Zoran; Janković, D; Jankovic, Irena; Jančić, Snežana

doi:10.1159/000321220

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…The treatment of radiation-induced ulcers is initially aimed at the removal of necrotic tissue, the elimination of bacteria, and the drainage of infected lesions. 13 , 14 …”

Section: Discussionmentioning

confidence: 99%

Successful use of a topical mixture with ozolipoile in the treatment of actinic ulcers

Inchingolo¹,

Cagiano²,

Resta³

et al. 2015

CCID

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PurposePost-radiation skin damage is the result of alterations produced in the irradiated zone. There are different studies aimed at verifying the effectiveness of several kinds of molecules in the treatment of radiation-induced skin damage. The purpose of this study is to test a mixture with a formulation containing several natural active ingredients on actinic ulcers in patients receiving radiation therapies.Patients and methodsThe authors recruited 13 patients, and randomly divided them into a test group (T1) and a control group (T2). The patients in both groups were undergoing radiotherapy. The T1 group was treated with a mixture called ozolipoile, whereas the T2 group was administered hyaluronic acid gel followed by non-ablative laser therapy. We evaluated the obtained results, the time of clinical healing, the reduction of pain, and each side effect, comparing all data between the T1 and T2 groups.ResultsThe average Visual Analog Scale results showed decrease in pain in both groups; however, while the T1 group showed a significant decrease in the values, the T2 group reported a more gradual reduction in the values, without ever reaching the minimum values obtained with the treatment with ozolipoile.ConclusionTreatment of actinic ulcers with ozolipoile mixture leads to faster control of pain and to better healing of small-size ulcers.

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“…The treatment of radiation-induced ulcers is initially aimed at the removal of necrotic tissue, the elimination of bacteria, and the drainage of infected lesions. 13 , 14 …”

Section: Discussionmentioning

confidence: 99%

Successful use of a topical mixture with ozolipoile in the treatment of actinic ulcers

Inchingolo¹,

Cagiano²,

Resta³

et al. 2015

CCID

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“…No side effects or adverse reactions were detected during five weeks of two-daily application of the extract-containing herbal preparations which support the safety and good tolerability of this product. Favorable action of herbal preparations on healing parameters and antibacterial effects are explained by the medical properties of DermaplantG plants and their extracts from the view-point of pharmacognosy, pharmacological and phytochemical studies (9)(10)(11)(12)(13)(14). The antimicrobial properties of garlic (Allium sativum) have been shown in many studies using different tests even against highly resistant pathogens.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous herbs and their extracts are potentially conducive to wound healing, including the ability to serve as an antimicrobial, antifungal, astringent and etc. (7)(8)(9)(10)(11). DermaplantG contain extracts of Allii bulbus, Hyperici herba and extract of Calendulae flos.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobiological Effects of New Natural Antiseptic Formulation on Non-Infected Venous Leg Ulcer: Pilot Study

Binić¹,

Janković²,

Miladinović³

et al. 2011

amm

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Venous leg ulcers represent a significant public health problem that will increase as the population ages. Numerous herbs and their extracts are potentially conducive to wound healing, including the ability to serve as antimicrobial, antifungal, astringent etc. The aim of the study was to establish the in-vivo antimicrobial effects of herbal hydrogel formulation DermaplantG. The major components of the DermaplantG were the extracts of Allii bulbus, Hyperici herba and extract of Calendulae flos. A total of 12 patients with non-infected venous leg ulcers were treated twice daily, for 5 weeks, with new hydrogel formulation. All ulcers showed clinical signs of contamination or colonization without signs of systemic infection. Premoistening the swab with sterile saline was considered when the surface of the wound was dry. The tip of the swab was rolled on its side in a zigzag pattern for at least one full rotation. Standard methods for isolation and identification of aerobic and anaerobic bacteria were used.On baseline assessment, a large number of different types of bacteria were detected in all venous leg ulcers. S. aureus and P. aeruginosa were isolated from almost all controls.On baseline, mixed bacterial flora (50%) was isolated in six venous leg ulcers (five ulcers with S. aureus-P. aeruginosa and one ulcer with E.coli-Enterobacter spp-P.aeruginosa). At the end of the treatment in DermaplantG group in 8 venous ulcers were detected S. aureus (66.66%) and P. aeruginosa (16.66%), and one venous leg ulcers was detected as sterile (8.33%). The number of different types of isolated bacterial species decreased significantly (P<0.05) after the use of DermaplantG herbal preparations. Therapy in DermaplantG group was administered without any side effects.The preliminary results of this pilot study demonstrate potential antimicrobial effects of herbal therapy on non-infected venous leg ulcers.

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Therapeutic effectiveness of aCalendula officinalisextract in venous leg ulcer healing

Buzzi¹,

Freitas²,

Winter³

2016

J Wound Care

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Can You Combine Herbal Therapy with Physical Agents in the Treatment of Venous Leg Ulcers?

Cited by 4 publications

References 6 publications

Successful use of a topical mixture with ozolipoile in the treatment of actinic ulcers

Successful use of a topical mixture with ozolipoile in the treatment of actinic ulcers

Antimicrobiological Effects of New Natural Antiseptic Formulation on Non-Infected Venous Leg Ulcer: Pilot Study

Therapeutic effectiveness of aCalendula officinalisextract in venous leg ulcer healing

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