Successful use of a topical mixture with ozolipoile in the treatment of actinic ulcers

Abstract

PurposePost-radiation skin damage is the result of alterations produced in the irradiated zone. There are different studies aimed at verifying the effectiveness of several kinds of molecules in the treatment of radiation-induced skin damage. The purpose of this study is to test a mixture with a formulation containing several natural active ingredients on actinic ulcers in patients receiving radiation therapies.Patients and methodsThe authors recruited 13 patients, and randomly divided them into a test group (T1) and a control group (T2). The patients in both groups were undergoing radiotherapy. The T1 group was treated with a mixture called ozolipoile, whereas the T2 group was administered hyaluronic acid gel followed by non-ablative laser therapy. We evaluated the obtained results, the time of clinical healing, the reduction of pain, and each side effect, comparing all data between the T1 and T2 groups.ResultsThe average Visual Analog Scale results showed decrease in pain in both groups; however, while the T1 group showed a significant decrease in the values, the T2 group reported a more gradual reduction in the values, without ever reaching the minimum values obtained with the treatment with ozolipoile.ConclusionTreatment of actinic ulcers with ozolipoile mixture leads to faster control of pain and to better healing of small-size ulcers.

A systematic review of ozone therapy for treating chronically refractory wounds and ulcers

“…Among all the included 12 articles with 1055 participants, the publishing dates ranged from 2005 to 2020. Involved wound types include second‐ or third‐degree actinic ulcers following a radiotherapy cycle, 25 chronic venous leg ulcers, 28,33 digital ulcers (DUs) in systemic sclerosis (SSc), 32 critical limb ischemia (CLI), 24 and diabetic foot ulcers 11,15,26,27,29‐31 . The proportion of participants with completely healed wounds were reported in seven trials 11,15,26,28,29,32,33 .…”

“…Twelve RCTs contributed to this systematic review. 11 , 15 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 A diagram of the selection of studies is shown in Figure 1 . A list of records excluded by reading the full text is shown in Table 3 .…”

“… 24 , 31 , 33 One trial 29 directly reported the total area closed after treatment. In three studies, 25 , 26 , 31 the intervention period was until the complete healing of wounds, 20 days in four studies, 11 , 15 , 27 , 32 30 days in one study, 33 3 weeks in one study, 30 12 weeks in one study, 29 and at least 22 weeks or until study completion in one trial. 24 One study for lower‐limb venous ulcers was conducted until wounds suitable for skin puncture.…”

“…Eight trials reported outcomes immediately following the course of therapy. 11 , 15 , 24 , 25 , 26 , 30 , 32 , 33 Two followed patients for 1 year after therapy. 28 , 31 One study followed 14 weeks or until they met the treatment outcome, 27 and one gave results at week 24.…”

Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review

“…Excellent results have been obtained on soft tissues, even from the use of a mixture of ozolipoilein, which, in only 3–5 days, can heal small ulcers caused by radiation therapy cycles. This blend is also antibacterial and antifungal [ 181 ]. Instead, PRF significantly contributes to tissue healing through its antibacterial properties, especially against S. aureus and E. Coli.…”