Therapeutic effectiveness of a<i>Calendula officinalis</i>extract in venous leg ulcer healing

Buzzi, Marcelo; Freitas, Franciele de; Winter, Marcos de Barros

doi:10.12968/jowc.2016.25.12.732

Cited by 39 publications

(55 citation statements)

References 38 publications

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“…Three studies assessed the effect of calendula extract ointments on burns . Three studies assessed the effect on chronic wound healing, of which two studies included patients with leg ulcers due to venous insufficiency and one included patients with diabetic ulcers . One study assessed the effect of calendula extract ointment on acute wound healing…”

Section: Resultsmentioning

confidence: 99%

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A systematic review of Calendula officinalis extract for wound healing

Givol

Kornhaber

Visentin

et al. 2019

Wound Repair Regeneration

104

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Use of complementary and alternative medicine for wound healing is influencing mainstream medical practice. This systematic review evaluates the role of Calendula officinalis flower extract as monotherapy compared to control for wound healing in vivo. Searches were conducted in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, CINAHL, and Scopus (up to April 2018) with 14 studies meeting the inclusion criteria, comprising 7 animal experiments and 7 clinical trials. Findings from the review on acute wound healing showed faster resolution of the inflammation phase with increased production of granulation tissue in the test groups treated with extract. These findings were consistent in five animal studies and one randomized clinical trial. Chronic wound healing studies were varied. Two clinical control studies on venous ulcers demonstrated decreased ulcer surface area compared to controls. Another randomized clinical trial demonstrated no improvement for the calendula group in diabetic leg ulcer healing. Burn healing similarly showed mixed results. Two animal studies demonstrated a prophylactic effect for the administration of calendula extract prior to burn injury. A randomized clinical trial of patients suffering from partial to full thickness burns demonstrated no benefit for topical application of calendula extract compared to controls. Two randomized clinical trials assessed the potential for extract to prevent acute post radiation dermatitis, with one study showing improvements compared to trolamine, while the other found no improvement compared to aqua gel cream. Animal studies provide moderate evidence for improved recovery from the inflammation phase and increased production of granulation tissue in calendula extract treatment groups. This review identified some evidence for the beneficial effects of C. officinalis extract for wound healing, consistent with its role in traditional medicine. There is a need for larger, well‐designed randomized control trials to assess the effect of calendula on wound healing including complications.

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Section: Resultsmentioning

confidence: 99%

“…C. officinalis extract has been found to contain many types of flavonoids, triterpenoids as well as polyphenols . in vitro studies with calendula alcohol extract have demonstrated additional biological effects.…”

Section: Introductionmentioning

confidence: 99%

A systematic review of Calendula officinalis extract for wound healing

Givol

Kornhaber

Visentin

et al. 2019

Wound Repair Regeneration

104

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“…Kandaswamy (2010) A review from 2015 summarized previous and recently published papers of the effects of two bee products, propolis and bee venom, on the wound healing, using mainly results obtained from preclinical experimentation. These data indicated that bee venom and propolis (Buzzi et al, 2016;Cioinac, 2016;Dinda et al, 2016;Fronza et al, 2009;Nicolaus et al, 2017;Parente et al, 2012;Patrick et al, 1996) have potential therapeutic properties in chronic diabetic wound, and the use of propolis and/or bee venom can be new effective intervention in clinical practice. However, their therapeutic effects should be proved by clinical studies, focusing on the advantage of using these agents over the current interventions, particularly in respect of therapeutic activities, safety, and cost effectiveness .…”

Section: Propolismentioning

confidence: 88%

“…regrowth of hair on the legs; and no adverse events were observed (Buzzi et al, 2016;Cioinac, 2016).…”

Section: Marigold Extracts Stimulate Proliferation and Migration Of 3t3mentioning

confidence: 92%

“…Clinical reports have used C . officinalis extract and ointment on patients with nonhealing venous leg ulcer (Buzzi, Freitas, & Winter, ) and patients diagnosed with diabetes and various injuries (microtraumas) on their lower and upper limbs (Cioinac, ), respectively. In both cases, the results were positive, with complete reepithelization; infection progress blocked; reducing itching, redness, pain, dryness, and healing time; disappearance of various scars; regrowth of hair on the legs; and no adverse events were observed (Buzzi et al, ; Cioinac, ).…”

Section: Calendula Officinalismentioning

confidence: 99%

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Natural actives for wound healing: A review

Ataide

Cefali

Croisfelt

et al. 2018

Phytotherapy Research

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Nature has been a source of medicinal treatments for thousands of years, with the use of plants as prototypes for drug development and for the extraction of active compounds. Skin injuries occur regularly in everyday life, and the human skin has the ability to promote repair spontaneously under healthy conditions. However, some intrinsic and external factors may interfere with skins' natural ability, leading to nonhealing lesions and chronic wounds, which directly affect health and quality of life. Thus, attention should be given to this health problem, using an appropriated management when necessary. In this scenario, phytotherapy may be an option for cutaneous wound treatment, although further high-quality studies are needed to firmly establish the clinical efficacy of plants. This article reviews traditionally used natural actives for wound healing, highlighting their characteristics and mode of action.

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