Evaluation of healing and antimicrobiological effects of herbal therapy on venous leg ulcer: pilot study

Binić, Ivana; Janković, Aleksandar; Janković, D; Jankovic, Irena; Vrućinić, Zoran

doi:10.1002/ptr.2931

Cited by 21 publications

(17 citation statements)

References 18 publications

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“…Huseini et al (2005) tested a seven-species product called Liv-52 in cirrhosis patients and found significant benefit; however, the small number of patients involved in the trial (a total of 36 in both arms) means that results cannot be taken as conclusive. Likewise, Binić et al (2010), also in a pilot study with few patients, reported that a three-herb topical preparation including yarrow healed surface and venous leg ulcers, outperforming a topical antibiotic.…”

Section: Clinical Trialsmentioning

confidence: 95%

Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research1

Applequist

Moerman

2011

Econ Bot

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Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research. Yarrow (Achillea millefolium L.) is one of the most widely used medicinal plants in the world, primarily for wounds, digestive problems, respiratory infections, and skin conditions, and secondarily, among other uses, for liver disease and as a mild sedative. Preclinical studies indicate that it may have anti-inflammatory, anti-ulcer, hepatoprotective, anxiolytic, and perhaps antipathogenic activities. Animal studies have also shown that yarrow is generally safe and well tolerated. The claim that yarrow has been shown to be specifically contraindicated during pregnancy is based on a single low-quality rat study the results of which were incorrectly interpreted. The combination of human use data from multiple cultures, independently reporting similar activities for yarrow, and the discovery of potentially relevant bioactivities by in vitro and animal studies represent meaningful evidence of the plant's efficacy. We therefore argue that human clinical trials should be funded and conducted.

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Section: Clinical Trialsmentioning

confidence: 95%

Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research1

Applequist

Moerman

2011

Econ Bot

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“…Binić et al, 2010 [66] RCT not blind 17 patients in experimental group and 15 patients in control group.…”

Section: Marigold (Calendula)mentioning

confidence: 99%

“…Binic et al presents the data of its pilot study RCT where 17 patients were treated with herbal therapies compared to 15 patients treated with topical antibiotics [66]. The ulcers of venous leg healed after seven weeks of treatment (p<0.05) and the number of different types of isolated bacterial species decreased.…”

Section: Herbal Therapiesmentioning

confidence: 99%

Complementary Medicine and Venous Ulcers: Review of Literature

Se¹

2017

Health Care Current Reviews

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Introduction: Complementary medicine has ancient historical roots and its use is constantly changing. It alongside scientific medicine is useful in the treatment of many diseases, including oncological, respiratory, and dermatological. It is used in the treatment of pain and in the local treatment of various ulcers (lesions) skin. In particular, scientific medicine uses several treatments for venous ulcers with not completely effective outcomes. Effective treatment prevents complications and improves the quality of life of patients. There is scientific evidence on the efficacy of complementary medicine in the treatment of venous ulcers of the lower limbs. Methods:It was performed as a literature review on the databases: MEDLINE, EMBASE and COCHRANE with the aim of detecting the evidence of efficacy of complementary medicine interventions in the treatment of venous ulcers and ways to treat it. We used the keywords and thesaurus descriptors for complementary medicine. We included the following drawings of relevant studies to the subject of the research: systematic reviews randomized controlled trials (RCTs), case control studies, observational studies, case reports, studies, and expert opinion in English, conducted on humans. For the purpose of this research, 174 documents were identified, of which only 15 were relevant and were within the inclusion criteria.Results: An analysis of the literature shows that many studies have evaluated the effectiveness of aloe, calendula, standardized extract from the aerial parts of A. pichinchensis, Mimosa tenuiflora, modified linen bandages, products made of honey found on the market, herbal therapies, polarized light therapy combined with herbal and plant biomembranes. However, these findings are insufficient to support or deny that one treatment is more effective than another. These results are not widely generalizable because of the low number of samples studied. Conclusion:Despite the interest in complementary medicine and the treatment of venous ulcers, there is currently no truly effective treatment strategy. The detected evidence is insufficient to make significant changes in the treatment of venous leg ulcers with complementary medicine interventions. The available studies on the treatment of venous leg ulcers with products based on plants have not established the existence of a treatment that may be effective individually. Additional studies would be needed to demonstrate the efficacy of these treatments.

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“…Cineol, tannin, and proazulene from yarrow calm inflammatory processes and help regeneration. Essential oils of sage have antibiotic effects and increase the phagocytic activity of leucocytes which partly affects wound healing [11][12][13]. Extract of marigold acts favourably on wound healing due to a synergistic action between essential oils, xanthophylls, saponins, and flavonoids.…”

Section: Methodsmentioning

confidence: 99%

“…Fitoven ® herbal gel, which contains alcoholic extracts of Aesculus hippocastanum, Melilotus officinalis, Rosmarini, and Lavandulae, is used in the treatment of varicose veins, chronic venous insufficiency, thrombophlebitis, haematomas, and haemorrhoids. Favourable actions of these herbal preparations on wound healing, antibacterial effects, high inhibitory effects on the production of hydroxyl radicals (OH) are described in different pharmacognostic, pharmacological, and phytochemical studies [11][12][13]. The aim of this pilot study was to evaluate healing and antimicrobiological effects of a combined treatment of electro-ionizing radiation, polarized light, and phytotherapy for venous leg ulcers.…”

mentioning

confidence: 99%

Can You Combine Herbal Therapy with Physical Agents in the Treatment of Venous Leg Ulcers?

Janković

Binić

Vrućinić³

et al. 2010

Forsch Komplementmed

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Introduction: Venous leg ulcers are an important and common health problem. The aim of this study was to determine the effects of herbal therapies alone or in combination with physical therapy in the treatment of venous ulcers, as well as their antibacterial effects. Patients and Methods: Our study included 60 patients (3 groups, 20 patients each) with non-infected venous leg ulcers. The patients were treated with herbal therapy alone (group HTC), with a combination of electro-ionizing radiation and herbal therapy (group ERHT) or with a combination of polarized light and herbal therapy (group PLHT). Results: Surface area and score of venous leg ulcers were followed clinically at baseline and at the end of 1, 3, 5, and 7 weeks of treatment. Comparing the results within the HTC, PLHT, and ERHT groups we found that the physical agents and herbal therapy significantly accelerated the healing of venous leg ulcers and reduced bacterial flora (p < 0.05). Comparing the results between the tested groups revealed no statistically significant difference (p > 0.05). Conclusions: Our results demonstrate healing and antibacterial effects of combined physical and herbal therapies, but no superiority of the combined treatment for venous leg ulcers as compared to treatment by herbal therapy alone.

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Evaluation of healing and antimicrobiological effects of herbal therapy on venous leg ulcer: pilot study

Cited by 21 publications

References 18 publications

Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research1

Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research1

Complementary Medicine and Venous Ulcers: Review of Literature

Can You Combine Herbal Therapy with Physical Agents in the Treatment of Venous Leg Ulcers?

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