Evaluation of Healing Effects of New Herbal Formulation on Venous Leg Ulcer: Pilot Study

Elstrom²,

The Journal of the American College of Certified Wound Speciali

et al. 2011

Chronic venous disorders are common in the Western world. The current treatment of venous leg ulcers is unsatisfactory despite the availability of well-documented standards of care. Patients today are interested in alternative approaches to modern medicine. We have developed a wound-healing powder containing natural ingredients with absorptive, aromatic, antiseptic, and anti-inflammatory synergistic properties. This report describes 3 cases that were successfully treated with the powder, demonstrating the potential of herbal remedies in the clinical treatment of venous leg ulcers.

mentioning

confidence: 99%

Novel Wound Healing Powder Formulation for the Treatment of Venous Leg Ulcers

Elstrom²,

The Journal of the American College of Certified Wound Speciali

et al. 2011

“…[97] Studies have demonstrated that calendula has properties that promote wound healing, including anti-inflammatory, antibacterial, antifungal, antioxidant, and pro-angiogenic. [98] Pommier et al compared the efficacy of calendula with triethanolamine and found that the incidence of RTOG grade II and above dermatitis was significantly lower in the calendula group than in the triethanolamine group, and fewer patients interrupted radiotherapy due to severe radiation dermatitis. [99] Babaee et al conducted a randomized controlled trial of calendula extract mouthwash as a treatment for radiation oropharyngeal mucositis in patients with head and neck cancer.…”

Section: Calendulamentioning

confidence: 99%

Radiation Skin Injury Care in Radiotherapy for Oncology: Mechanisms, Drug Therapy and Novel Biomaterial Application Strategies

Wang

Yang

Liu

et al. 2023

Advanced Therapeutics

Radiation skin injury (RSI) is a frequent adverse effect of radiation therapy for malignant tumors. It often leads to problems such as decreased quality of life in patients and interferes with the normal course of radiation therapy (RT). With the rising incidence of tumors and the burgeoning number of patients undergoing RT, the care of RSI is of crucial importance in cancer patient treatment. Currently, drugs and biomaterials are widely used in the care of RSI. However, there is no international consensus on the current protocol for the therapeutic care of RSI. Many drugs and biomaterials cannot be applied to the appropriate type of radiation dermatitis, resulting in unfavorable results in the therapeutic care of RSI. The choice of appropriate drugs and biomaterials for the therapeutic care of the different types of RSI is essential to improving the quality of life of patients. This article first reviews the main mechanisms of acute and chronic RSI. Subsequently, the application of drugs and novel biomaterials in the preventive, acute, and chronic phases of the care of RSI is summarized. Finally, the suggestions and protocols for the application of novel biomaterials in the care of RSI are discussed, as are the current challenges and future prospects for the development of combined biomaterials and integrated care solutions.

“…Light compression hosiery is indicated for treating mild varicose veins; medium compression for pronounced varicosity with edema and strong compression for late complications of constitutional or post thrombotic venous insufficiency, atrophie blanche, dermatosclerosis [24]. However the most effective level of compression to overcome venous hypertension has been determined to be around 40 mm Hg at the ankle recent Cochrane review provides the most complete overview on randomized controlled compression ulcers and concluded that compression clearly increases the rate of healing as compared to no compression [25].…”

Section: Figure 1: Chronic Ulcer On the Medial Malleolusmentioning

confidence: 99%

“…However the most effective level of compression to overcome venous hypertension has been determined to be around 40 mm Hg at the ankle [21]. The recent Cochrane review provides the most complete overview on randomized controlled compression-trials in venous leg ulcers and concluded that compression clearly increases the rate of healing as compared to no compression [25].…”

Section: Figure 1: Chronic Ulcer On the Medial Malleolusmentioning

confidence: 99%

Current understanding on venous leg ulcer

Alok

Bhardwaj

Singh

et al. 2014

IJPBR

Venous leg ulcer (VLU) or stasis ulcer is a relatively common, chronic and recurring problem. Besides being costly to the health-care system, it significantly impairs the quality of life of the patients. Nearly 1% of adults and 3.6% of older patients are reported to suffer from this chronic condition. Chronic venous insufficiency is considered to be the predominant cause of VLU. The most recent theories associate the pathogenesis of venous ulcer with microcirculatory abnormalities and generation of an inflammatory response. The pharmacological treatment for VLU is based on the pathogenesis and often includes diosmin, pentoxifylline, diuretics as well as antibiotics and the non-pharmacological treatment like compression and skin grafting. VLU has a high rate of recurrence and requires self-care to avoid relapse. Treatment of VLU should always focus for complete treatment, and improve quality of life for patients along with minimum relapse. In recent years novel therapeutic approaches for venous ulcers have offered valuable tools for the management of patients with this disorder.