Abstract. Excessive activation of the hedgehog (Hh) signaling pathway is important in a variety of human cancer cell types, including gastric cancer. However, the underlying mechanisms of the Hh signaling pathway in inducing gastric tumorigenesis and its downstream target genes are largely unknown. In the present study, the inhibitory effect of cyclopamine on the Hh signaling pathway was investigated in the human gastric cancer AGS cell line. It was identified that cyclopamine treatment inhibited the proliferation, migration and invasion of the AGS cells in a dose-and time-dependent manner, and resulted in the downregulation of a number of key Hh signaling pathway-associated factors [glioma-associated oncogene homolog 1, C-X-C chemokine receptor type 4 and transforming growth factor (TGF)-β1] at the RNA and protein levels. Furthermore, the secretion of TGF-β1 was significantly reduced following the administration of cyclopamine to the AGS cells. The results of the present study provided insight into the mechanisms by which the Hh signaling pathway regulates gastric cancer formation and identified the Hh signaling pathway as a potential novel therapeutic target in human gastric cancer.

No abstract

In order to study the effect of fulvic acids (FA) on the migration of TNT in soil, batch experiments in which 2%, 5% and 10% (w/w) of FA were added to soils were conducted.Adsorption kinetics and adsorption-desorption isotherms of TNT in soils were investigated, with results of the kinetics tests showing that the adsorption process could be divided into a fast and a slow stage and that FA could extend the adsorption time. Kinetic datas were fit to pseudo first-order, pseudo second-order, Elovich and intra-particle diffusion kinetic models. The fitting results showed that a pseudo second-order kinetic model best described the adsorption process, while Elovich and intra-particle diffusion kinetic models could accurately predict the adsorption at higher FA content. The adsorption-desorption isotherms were predicted using Linear, Freundlich, and Langmuir isotherm models. Results showed that the Freundlich model best described the adsorption-desorption process, and that FA increased adsorption capacity and enhanced the adsorption affinity. The hysteresis index suggested that FA could reduce the desorption of TNT in soil.

No abstract

The concrete was made :from standard sand, steel fiber, iron ore-sand, carbon-fiber felt, ZnO whisker, ferrite, acetylene gas black, carbonyl iron, so that the concrete shielding material has the microwave absorbing performance. It is to search for a new protection way of grand buildings and martial biding constructions. The concrete shielding material is first analyzed in 3mm wave bands. The paper focuses on the different absorption characteristic of concrete with different material and different content. The relation of content is discussed. It is guide for the future research