Nanostructured manganese dioxide (MnO2) has attracted extensive attention in the field of anticancer applications. As we all know, the tumor microenvironment is usually characterized by high glutathione (GSH) concentration, overproduced...
Nanomaterials can offer a chance to integrate many excellent physical and chemical performances into a single carrier for smart responsive drug delivery. Herein, gold nanorods/mesoporous manganese dioxide (Au/MnO 2 ) hybrid nanoparticles were prepared to combine the photothermal effect of gold nanorods (AuNRs) with glutathione (GSH)-responsive and pH-responsive performances of MnO 2 . The near-infrared (NIR) responsive constituent of a Au/MnO 2 nanoparticle was AuNRs. Doxorubicin hydrochloride (DOX), a widely used anticancer drug, was loaded into the Au/MnO 2 hybrid nanoparticle via electrostatic force, hydrogen bonding, and physical absorption with a drug loading up to 99.1%. The results revealed that the mesoporous MnO 2 was degraded in the media with high concentrations of GSH and acid microenvironment. The Au/MnO 2 nanoparticles displayed satisfying drug release kinetics (ca. 47% of loaded drug released in 12 h) and showed excellent GSH-responsive, pH-responsive, and NIR-responsive performances. This multiresponsive nanoplatform is expected to have wide biomedical application for cancer therapy such as photothermal therapy, drug delivery, and tumor microenvironment improvement.
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