Thermosensitive hydrogel-functionalized gold nanorod/mesoporous MnO2 nanoparticles for tumor cell-triggered drug delivery

Zhang, Zheng; Ji, Yuanhui; Lin, Chengqi; Li, Tao

doi:10.1016/j.msec.2021.112504

Cited by 19 publications

(17 citation statements)

References 60 publications

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“…35 The spectrum of mMnO 2 indicates the peaks located at 528 cm À1 (Mn O stretching) and 3434 cm À1 (O H stretching). 36 In the case of mMnO 2 -MTX, the characteristic peak of MTX at 2946 cm À1 shifts to 2974 cm À1 , which might be caused by the interaction between MTX and mMnO 2 . The two weak peaks at 1512 and 1288 cm À1 on the spectrum of PDA are due to the bending of N H 37 and the catechol (C OH) group of PDA, 38 respectively.…”

Section: Xrd Patterns Of Mtx Mmno 2 Mmno 2 -Mtx and Mmno 2 -Mtx-pdamentioning

confidence: 96%

“…As previously reported, GSH and acidic solutions can result in the degradation of MnO 2 through the following equations: (1) 36 On the other hand, PDA can also be degraded by GSH and acidic solutions because GSH and acidic solutions can change or even destroy the polymerization state of PDA. 1,22 Here, GSH and low pH-triggered degradation of the mMnO 2 -MTX-PDA is investigated, and the results are presented in Figure 8.…”

Section: Biodegradability Of Mmno 2 -Mtx-pdamentioning

confidence: 97%

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A biodegradable drug‐controlled delivery system based on mesoporous manganese dioxide and poly(dopamine)

Li,

Cai,

Jiang

et al. 2023

Bulletin Korean Chem Soc

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Mesoporous manganese dioxide (mMnO2) was first synthesized for the loading of methotrexate (MTX), and then dopamine was in situ polymerized on the surface of the MTX‐loaded mMnO2 (mMnO2‐MTX) in an alkaline solution to encapsulate the drug in the mesopores of mMnO2. Both low pH and glutathione (GSH) can result in the degradation of mMnO2 and poly(dopamine) (PDA), and thus the delivery of MTX from the mMnO2‐MTX‐PDA can be triggered by low pH and GSH. Near‐infrared (NIR) light‐responsive delivery of MTX can be achieved owing to the outstanding photothermal conversion capability of PDA; on the other hand, the mMnO2‐MTX‐PDA can be utilized for photothermal therapy under the irradiation of NIR light due to the elevated temperature. The results of cytotoxicity test demonstrate that the pH, GSH, and NIR light tri‐responsive drug‐controlled delivery system has excellent biocompatibility, while exhibits pronounced growth inhibition against murine breast tumor cell line 4T1.

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Section: Xrd Patterns Of Mtx Mmno 2 Mmno 2 -Mtx and Mmno 2 -Mtx-pdamentioning

confidence: 96%

Section: Biodegradability Of Mmno 2 -Mtx-pdamentioning

confidence: 97%

A biodegradable drug‐controlled delivery system based on mesoporous manganese dioxide and poly(dopamine)

Li,

Cai,

Jiang

et al. 2023

Bulletin Korean Chem Soc

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“…A hydrogel encapsulated with mesoporous manganese dioxide can relieve localized oxidative stress and prolonged oxygen deprivation via effective oxygen generation [ 91 ]. Mesoporous manganese dioxide also can help composite hydrogels achieve satisfactory glutathione/pH/thermal-responsive controlled drug release in the tumor microenvironment, which is attributed to the fact that manganese dioxide is a redox-active material and can be degraded under glutathione, H 2 O 2 , and acid conditions [ 64 , 92 ]. Mesoporous polydopamine is a new material with good biocompatibility and excellent photothermal properties, which can effectively convert near-infrared light into heat and kill cancer cells in vivo and in vitro [ 93 ].…”

Section: Classification Of Mesoporous Material-loaded Composite Hydro...mentioning

confidence: 99%

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

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Scientists have been attempting to improve the properties of mesoporous materials and expand their application since the 1990s, and the combination with hydrogels, macromolecular biological materials, is one of the research focuses currently. Uniform mesoporous structure, high specific surface area, good biocompatibility, and biodegradability make the combined use of mesoporous materials more suitable for the sustained release of loaded drugs than single hydrogels. As a joint result, they can achieve tumor targeting, tumor environment stimulation responsiveness, and multiple therapeutic platforms such as photothermal therapy and photodynamic therapy. Due to the photothermal conversion ability, mesoporous materials can significantly improve the antibacterial ability of hydrogels and offer a novel photocatalytic antibacterial mode. In bone repair systems, mesoporous materials remarkably strengthen the mineralization and mechanical properties of hydrogels, aside from being used as drug carriers to load and release various bioactivators to promote osteogenesis. In hemostasis, mesoporous materials greatly elevate the water absorption rate of hydrogels, enhance the mechanical strength of the blood clot, and dramatically shorten the bleeding time. As for wound healing and tissue regeneration, incorporating mesoporous materials can be promising for enhancing vessel formation and cell proliferation of hydrogels. In this paper, we introduce the classification and preparation methods of mesoporous material-loaded composite hydrogels and highlight the applications of composite hydrogels in drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. We also summarize the latest research progress and point out future research directions. After searching, no research reporting these contents was found.

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“…Another keyword appeared recently in TOP 16 keywords with the strongest citation bursts was "responsive hydrogels", which includes "thermosensitive hydrogel" generated by trends of keyword occurrences map, indicating that responsive hydrogels are the current research hotspots and direction. Various stimuli responsive NHs have been investigated for controlled drug delivery, such as pH responsive (Barkhordari et al, 2014), electroresponsive (Yan et al, 2012), thermosensitive (Zhang et al, 2021), magnetic responsive and light-responsive (Yan et al, 2012) ones. Moreover, targeted drug delivery has received more attention, especially in cancer treatment.…”

Section: Papermentioning

confidence: 99%

Knowledge mapping concerning applications of nanocomposite hydrogels for drug delivery: A bibliometric and visualized study (2003–2022)

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Background: Nanocomposite Hydrogels (NHs) are 3D molecular networks formed by physically or covalently crosslinking polymer with nanoparticles or nanostructures, which are particularly suitable for serving as carriers for drug delivery systems. Many articles pertaining to the applications of Nanocomposite Hydrogels for drug delivery have been published, however, the use of bibliometric and visualized analysis in this area remains unstudied. The purpose of this bibliometric study intended to comprehensively analyze the knowledge domain, research hotspots and frontiers associated with the applications of Nanocomposite Hydrogels for drug delivery.Methods: We identified and retrieved the publications concerning the applications of NHs for drug delivery between 2003 and 2022 from Web of Science Core Collection Bibliometric and visualized analysis was utilized in this investigative study.Results: 631 articles meeting the inclusion criteria were identified and retrieved from WoSCC. Among those, 2,233 authors worldwide contributed in the studies, accompanied by an average annual article increase of 24.67%. The articles were co-authored by 764 institutions from 52 countries/regions, and China published the most, followed by Iran and the United States. Five institutions published more than 40 papers, namely Univ Tabriz (n = 79), Tabriz Univ Med Sci (n = 70), Islamic Azad Univ (n = 49), Payame Noor Univ (n = 42) and Texas A&M Univ (n = 41). The articles were published in 198 journals, among which the International Journal of Biological Macromolecules (n = 53) published the most articles, followed by Carbohydrate Polymers (n = 24) and ACS Applied Materials and Interfaces (n = 22). The top three journals most locally cited were Carbohydrate Polymers, Biomaterials and Advanced materials. The most productive author was Namazi H (29 articles), followed by Bardajee G (15 articles) and Zhang J (11 articles) and the researchers who worked closely with other ones usually published more papers. “Doxorubicin,” “antibacterial” and “responsive hydrogels” represent the current research hotspots in this field and “cancer therapy” was a rising research topic in recent years. “(cancer) therapeutics” and “bioadhesive” represent the current research frontiers.Conclusion: This bibliometric and visualized analysis offered an investigative study and comprehensive understanding of publications regarding the applications of Nanocomposite Hydrogels for drug delivery from 2003 to 2022. The outcome of this study would provide insights for researchers in the field of Nanocomposite Hydrogels applications for drug delivery.

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Thermosensitive hydrogel-functionalized gold nanorod/mesoporous MnO2 nanoparticles for tumor cell-triggered drug delivery

Cited by 19 publications

References 60 publications

A biodegradable drug‐controlled delivery system based on mesoporous manganese dioxide and poly(dopamine)

A biodegradable drug‐controlled delivery system based on mesoporous manganese dioxide and poly(dopamine)

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Knowledge mapping concerning applications of nanocomposite hydrogels for drug delivery: A bibliometric and visualized study (2003–2022)

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