Nanostructured manganese dioxide for anticancer applications: preparation, diagnosis, and therapy

Zhang, Zheng; Ji, Yuanhui

doi:10.1039/d0nr04067c

Cited by 66 publications

(33 citation statements)

References 241 publications

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“…Some Mn‐based nanomaterials such as MnO 2 which is a nanomaterial with strong adsorption capacity, large specific surface area, and good biocompatibility, can be used as a nanocarrier for the loading of various anticancer drugs. [ 280 ] The electrostatic interaction is the main driving force of drug loading via MnO 2 ‐based nanomaterials, and the MnO 2 structures with pores (e.g., the honeycomb nanostructure) can improve the drug loading efficiency. [ 281 ] Besides, MnO 2 can be rapidly degraded in tumor cells due to tumor acidic pH and high concentration of GSH, which can be used for the release of chemotherapeutic drugs in some anticancer strategies.…”

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

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358

212

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Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in the tumor region, was first proposed by Bu, Shi, and co‐workers in 2016. Recently, with the rapid development of Fenton and Fenton‐like nanomaterials, CDT has attracted tremendous attention because of its unique advantages: 1) It is tumor‐selective with low side effects; 2) the CDT process does not depend on external field stimulation; 3) it can modulate the hypoxic and immunosuppressive tumor microenvironment; 4) the treatment cost of CDT is low. In addition to the Fe‐involved CDT strategies, the Fenton‐like reaction‐mediated CDT strategies have also been proposed, which are based on many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, and zinc. Moreover, CDT has been combined with other therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, and immunotherapy for achieving enhanced anticancer effects. Besides, there have also been studies that extend the application of CDT to the antibacterial field. This review introduces the latest advancements in the nanomaterials‐involved CDT from 2018 to the present and proposes the current limitations as well as future research directions in the related field.

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Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

Small

358

212

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“…Among them, manganese dioxide (MnO 2 ), one of the redox active layered transition-metal dioxide nanomaterials, is being intensively explored as a novel delivery vehicle due to its distinctive properties [52]. For instance, MnO 2 possesses a large surface area, providing it with great drugloading capacity for anti-cancer drug delivery [53]. MnO 2 is biodegradable because of its excellent catalytic activity and oxidation ability.…”

Section: Manganese Oxide Nanomaterialsmentioning

confidence: 99%

Multifunctional inorganic nanomaterials for cancer photoimmunotherapy

Tang

Zhang

et al. 2022

Cancer Communications

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Phototherapy and immunotherapy in combination is regarded as the ideal therapeutic modality to treat both primary and metastatic tumors. Immunotherapy uses different immunological approaches to stimulate the immune system to identify tumor cells for targeted elimination. Phototherapy destroys the primary tumors by light irradiation, which induces a series of immune responses through triggering immunogenic cancer cell death. Therefore, when integrating immunotherapy with phototherapy, a novel anti-cancer strategy called photoimmunotherapy (PIT) is emerging. This synergistic treatment modality can not only enhance the effectiveness of both therapies but also overcome their inherent limitations, opening a new era for the current anti-cancer therapy. Recently, the advancement of nanomaterials affords a platform for PIT. From all these nanomaterials, inorganic nanomaterials stand out as ideal mediators in PIT due to their unique physiochemical properties. Inorganic nanomaterials can not only serve as carriers to transport immunomodulatory agents in immunotherapy owing to their excellent drug-loading capacity but also function as photothermal agents or photosensitizers in phototherapy because of their great optical characteristics. In this review, the recent advances of multifunctional inorganic nanomaterial-mediated drug delivery and their contributions to cancer PIT will be highlighted.

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“…The NPs based on MnO 2 have been widely used for tumor diagnosis because of their catalytic activity and oxidizing properties. [ 148 ] The fluorescent biosensors, calorimetric biosensors electrochemical biosensors are three of the most commonly used biosensors. The MnO 2 ‐based nanostructure can quench the fluorescence of dyes, subsequent the quenched fluorescence recovered when MnO 2 was decomposed to Mn 2+ ions by the reducing substance (for instance, GSH and H 2 O 2 ).…”

Section: Multimodal Imaging and Cancer Diagnosismentioning

confidence: 99%

Hollow Mesoporous Manganese Oxides: Application in Cancer Diagnosis and Therapy

Qing

Liu

et al. 2022

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The precision, minimal invasiveness, and integration of diagnosis and treatment are critical factors for tumor treatment at the present. Although nanomedicine has shown the potential in tumor precision treatment, nanocarriers with high efficiency, excellent targeting, controlled release, and good biocompatibility still need to be further explored. Hollow mesoporous manganese oxides nanomaterials (HM‐MONs), as an efficient drug delivery carrier, have attracted substantial attention in applications of tumor diagnosis and therapy due to their unique properties, such as tumor microenvironment stimuli‐responsiveness, prominent catalytic activity, excellent biodegradation, and outstanding magnetic resonance imaging ability. The HM‐MONs can not only enhance the therapeutic efficiency but also realize multimodal diagnosis of tumors. Consequently, it is necessary to introduce applications based on HM‐MONs in cancer diagnosis and therapy. In this review, the representative progress of HM‐MONs in synthesis is discussed. Then, several promising applications in drug delivery, bio‐imaging, and bio‐detection are highlighted. Finally, the challenges and perspectives of the anticancer applications are summarized, which is expected to provide meaningful guidance on further research.

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Nanostructured manganese dioxide for anticancer applications: preparation, diagnosis, and therapy

Abstract: Nanostructured manganese dioxide (MnO2) has attracted extensive attention in the field of anticancer applications. As we all know, the tumor microenvironment is usually characterized by high glutathione (GSH) concentration, overproduced...

Cited by 66 publications

References 241 publications

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Multifunctional inorganic nanomaterials for cancer photoimmunotherapy

Hollow Mesoporous Manganese Oxides: Application in Cancer Diagnosis and Therapy

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