ObjectivesWe recommend a new kind of spray made from eight kinds of traditional Chinese medicine, we aimed to investigate the safety and clinical efficacy of combined traditional Chinese medicine spray (TCMS) with premature ejaculation desensitization therapy (PEDT) for the treatment of primary premature ejaculation (PPE).MethodsA total of 90 patients with PPE were randomly assigned to receive TCMS, PEDT monotherapy or TCMS plus PEDT combination therapy for 6 weeks. Intravaginal ejaculation latency time (IELT) and Chinese index of sexual function for premature ejaculation (CIPE-5) were measured to evaluate the effect of each treatment.ResultsEighty six (86) participants completed the study voluntarily. Both IELT and CIPE-5 in these three groups increased after treatment when compared with baseline levels (p< 0.01). IELT and CIPE-5 after treatment in TCMS plus PEDT group were significantly higher than those in the other two groups (both p <0.05). Additionally, clinical efficacy in TCMS plus PEDT group (89.7%) was significantly higher than in TCMS (65.5%) and PEDT group (67.9%) (p< 0.01).ConclusionThe self-made TCMS was safe and effective for the treatment of PPE, a combination of TCMS and PEDT therapy was more effective than the TCMS or PEDT monotherapy.
Objective: To contrast the clinical effects and complications for the treatment of T1 renal carcinoma in partial nephrectomy (PN) and radical nephrectomy (RN). Methods: Multiple databases were adopted to search relevant studies, and articles that eventually satisfied the inclusion criteria were included. All meta-analyses were conducted with the Review Manager 5.0, and to estimate the quality of each article, risk of bias table was performed. Results: In the end, 13 studies including 13,269 patients were involved, which eventually satisfied the eligibility criteria. The number of samples in the PN group and the RN group were 6,145 and 7,124 respectively. The results of heterogeneity test suggested that the operating time (mean difference [MD] = –13.02, 95% CI [–14.15 to –11.89], p < 0.00001; p for heterogeneity < 0.00001, I2 = 100%), glomerular filtration rate (GFR) at 24 h after surgery (MD = 11.28, 95% CI [10.71–11.85], p < 0.00001; p for heterogeneity < 0.000001, I2 = 98%), and recurrence (OR 0.99, 95% CI [0.51–1.93], p = 0.97; p for Heterogeneity = 0.73, I2 = 0%) were significantly different, while differences in GFR at 24 h before surgery (MD = 0.59, 95% CI [0.06–1.12], p = 0.03; p for heterogeneity < 0.000001, I2 = 76%) between PN and RN were insignificant. Conclusion: This study demonstrated that clinical efficacy of RN was better than that of PN to some extent, but PN was a quicker recovery and less harmful therapy.
Background
The prognosis of patients with prostate cancer (PCa) remains poor.
Methods
GSE16560, GSE32448, GSE79957, GSE17951, and TCGA‐PRAD were reanalyzed to evaluate the expression of homeobox B7 (HOXB7) between PCa tissues and normal prostate tissues and to characterize the correlation between the expression of HOXB7 and the clinicopathological features of patients with PCa. Gene set enrichment analysis was conducted to investigate the mechanisms.
Results
HOXB7 was upregulated in PCa tissues (P = 0.0005). Both the univariate and multivariate analyses demonstrated that the expression of HOXB7 was correlated with the Gleason score and TNM staging of patients with PCa. The Gleason score and TNM staging were higher in the HOXB7 high expression group. The overall survival (hazard ratio [HR] = 0.632; 95% confidence interval [CI]: 0.4773‐0.8369;
P = 0.0014) and progression‐free survival (HR = 0.544; 95% CI: 0.3157‐0.9373;
P = 0.0283) favored patients with PCa in HOXB7 low expression group over those in HOXB7 high expression group. PCa samples in HOXB7 low expression group were enriched in gene sets associated with the epithelial mesenchymal transition, apical junction, angiogenesis, ultraviolet response, and hypoxia.
Conclusions
HOXB7 might be an independent prognostic factor of patients with PCa.
The topology of isofrequency surface governs the electromagnetic wave propagation and light–matter interaction in metamaterials. For most metamaterials with local medium description, the low-frequency isosurfaces are typical spheres or ellipsoids centered at zero momentum, which, to some extent, limits our manipulation ability on low-frequency wave. In this work, based on connection-type wire metamaterials, we propose a scheme to engineer the shapes of isofrequency surfaces. An equivalent circuit model is developed to analyze the low-frequency dispersion of connection-type metamaterials. It implies that the shape of index ellipsoids at quasistatic limit is determined by the equivalent inductances and capacitances of the metallic meshes. By adjusting these equivalent circuit parameters, we can achieve the isotropic or anisotropic index ellipsoids at quasistatic limit and, hence, a cruciform or bowtie-shaped isofrequency contours for the lowest-frequency band. Our results demonstrate a feasible platform for topological engineering of isofrequency surfaces, which may pave the way to novel devices for manipulating long-wavelength electromagnetic wave.
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