Comparison of Radical Nephrectomy and Partial Nephrectomy for T1 Renal Cell Carcinoma: A Meta-Analysis

Yang, Chao; Liao, Zhaolin

doi:10.1159/000490576

Cited by 13 publications

(10 citation statements)

References 25 publications

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“…All the patients underwent operations successfully which were selected in accordance with general population, and 15 patients with radical nephrectomy and 4 with partial nephrectomy. The 4 patients who underwent partial nephrectomy are still alive without local recurrence or distant metastasis with mean follow-up of 43 months, the same outcome as in general patients [17]. There were a large number of literatures on radical versus partial nephrectomy for cT1 renal cell carcinoma.…”

Section: Discussionmentioning

confidence: 87%

Human immunodeficiency virus-related renal cell carcinoma: a retrospective study of 19 cases

Zhang

Zhu

Xue

et al. 2021

Infect Agents Cancer

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Purpose We aimed to investigate basic information, clinical findings, treatments for tumor, pathology, and outcomes of HIV-positive patients diagnosed with renal cell carcinoma (RCC). Patients and methods We collected 19 patients from 2012 to 2020 who are diagnosed with RCC with HIV-positive. A retrospective analysis was performed on their hospitalization course and tumor-related parameters, including basic information, clinical findings, HIV-associated data, pathology, treatments for tumor, and outcomes. Results In our study, patients were diagnosed with RCC at the median age of 51. Males took a great part (17 males, 89%) in all patients, while only 2 females were diagnosed. The median CD4+ T lymphocyte cell count was 462 cells/μl when diagnosed with RCC (range from 111 cells/μl to 1536 cells/μl). Eleven patients diagnosed with RCC and HIV infection at the same time, who may have high viral load and low CD4+ T lymphocyte cell count. Eight patients accepted a median HAART for 30 months (range from 11 months to 108 months) prior to diagnosis of RCC. All the patients performed operations successfully, and 4 of them performed partial nephrecotomy. Only 1 patient was identified with chromophobe cell carcinoma, 1 with partially clear cell and partially papillary carcinoma, and 17 with clear cell carcinoma. Two of the patients with Fuhrman grades 2–3 accepted cytokine therapy with IL-2 and IFN-α. Two patients died of lung metastasis 1 year and 6 months after surgery respectively, even though 1 patient accepted full dose targeted therapy (sorafenib) for 3 months, and one refused adjuvant therapy. The remaining 17 patients are still alive at a median follow-up of 34 months; however, 1 patient lives with lung and brain metastases at the last follow-up of 3 years after surgery. Conclusions RCC patients with HIV-positive were similar to the general population in terms of clinical characters, treatment measures, and pathology. RCC patients with HIV-positive seemed like to obey the same clinical practice guideline as in the general population. The outcomes of HIV-positive patients with partial nephrectomy are not inferior to patients with radical nephrectomy. Furthermore, experience in targeted therapy and immunal therapy (PD-1/PD-L1 inhibitors) needs to be learned.

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Section: Discussionmentioning

confidence: 87%

Human immunodeficiency virus-related renal cell carcinoma: a retrospective study of 19 cases

Zhang

Zhu

Xue

et al. 2021

Infect Agents Cancer

View full text Add to dashboard Cite

show abstract

“…All the patients underwent operations successfully which were selected in accordance with general population, and 15 patients with radical nephrectomy and 4 with partial nephrectomy. The 4 patients who underwent partial nephrectomy are still alive without local recurrence or distant metastasis with mean follow-up of 43 months, the same outcome as in general patients [17].There were a large number of literatures on radical versus partial nephrectomy for cT1 renal cell carcinoma. A recent study consisted of a total number of 2459 adults in the united states who were treated with radical or partial nephrectomy.…”

Section: Discussionmentioning

confidence: 87%

Human Immunodeficiency Virus Related Renal Cell Carcinoma: a Retrospective Study of 19 Cases

Zhang

Zhu

Xue

et al. 2021

Preprint

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Purpose: We aimed to investigate basic information, clinical findings, treatments for tumor, pathology and outcomes of HIV-positive patients diagnosed renal cell carcinoma(RCC). Patients and Methods: We collected 19 patients from 2012 to 2020 who diagnosed RCC with HIV- positive. A retrospective analyze was performed on their hospitalization course and tumor related parameters, including basic information, clinical findings, HIV associated datas, pathology, treatments for tumor and outcomes.Results: In our study, patients were diagnosed RCC at the median age 51. Males took a great part(17 males,89%) in all patients, while only 2 females were diagnosed. The median CD4+ T-lymphocyte cell count was 462 cells/ul when diagnosed RCC(range from 111 cells/ul to 1536 cells/ul). 11 patients diagnosed RCC and HIV infection at the same time, who may have high viral load and low CD4+ T-lymphocyte cell count. 8 patients accepted a median HAART for 30 months(range from 11 months to 108months) prior to diagnosis of RCC. All the patients performed operations successfully, and 4 of them performed partial nephrecotomy. Only 1 patient was identified with chromophobe cell carcinoma, 1 with partially clear cell and partialy papillary carcinoma, and 17 with clear cell carcinoma. 2 of the patients with Fuhrman grade2-3 accepted cytokine therapy with IL-2 and IFN-α. 2 patients died of lung metastasis one year and six months after surgery respectively, even though 1 patient accepted full dose targeted therapy (Sorafenib) for 3 months, and one refused adjuvant therapy. The remaining 17 patients are still alive at a median follow-up of 34 months, however 1 patient live with lung and brain metastases at last follow-up of 3 years after surgery.Conclusions: RCC Patients with HIV-positive were similar to general population in terms of clinical characters, treatment measures, and pathology. RCC patients with HIV- positive seemed like to obey the same clinical practice guideline as in general population. The outcomes of HIV-positive patients with partial nephrectomy are not inferior to patients with radical nephrectomy. Further more experience in targeted therapy and immunal therapy( PD-1/ PD-L1 inhibitors) needs to be learned.

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“…In the matched cohort, patients in the PN group showed a longer OT and more EBL relative to those in the RN group. A systematic review and meta-analysis by Yang et al comprising 13 retrospective cohort studies with 13,269 patients showed that lower EBL was associated with PN and not RN for T1 renal tumor (25). Li et al reported a similar result in another metaanalysis (26).…”

Section: Discussionmentioning

confidence: 90%

“…A systematic review and meta-analysis by Yang et al. comprising 13 retrospective cohort studies with 13,269 patients showed that lower EBL was associated with PN and not RN for T1 renal tumor ( 25 ). Li et al.…”

Section: Discussionmentioning

confidence: 99%

Partial Nephrectomy Versus Radical Nephrectomy for Endophytic Renal Tumors: Comparison of Operative, Functional, and Oncological Outcomes by Propensity Score Matching Analysis

Xiong

Jiang

et al. 2022

Front. Oncol.

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PurposeThe study aimed to compare operative, functional, and oncological outcomes between partial nephrectomy (PN) and radical nephrectomy (RN) for entophytic renal tumors (ERTs) by propensity score matching (PSM) analysis.MethodsA total of 228 patients with ERTs who underwent PN or RN between August 2014 and December 2021 were assessed. A PSM in a 1:1 ratio was conducted to balance the differences between groups. Perioperative characteristics, renal functional, and oncological outcomes were compared between groups. Univariate and multivariate logistic and Cox proportional hazard regression analyses were used to determine the predictors of functional and survival outcomes.ResultsAfter PSM, 136 cases were matched to the PN group (n = 68) and the RN group (n = 68). Patients who underwent RN had shorter OT, less EBL, and lower high-grade complications (all p <0.05) relative to those who underwent PN. However, better perseveration of renal function was observed in the PN group, which was reflected in 48-h postoperative AKI (44.1% vs. 70.6%, p = 0.002), 1-year postoperative 90% eGFR preservation (45.6% vs. 22.1%, p = 0.004), and new-onset CKD Stage ≥III at last follow-up (2.9% vs. 29.4%, p <0.001). RN was the independent factor of short-term (OR, 2.812; 95% CI, 1.369–5.778; p = 0.005) and long-term renal function decline (OR, 10.242; 95% CI, 2.175–48.240; p = 0.003). Furthermore, PN resulted in a better OS and similar PFS and CSS as compared to RN (p = 0.042, 0.15, and 0.21, respectively). RN (OR, 7.361; 95% CI, 1.143–47.423; p = 0.036) and pT3 stage (OR, 4.241; 95% CI, 1.079–16.664; p = 0.039) were independent predictors of overall mortality.ConclusionAmong patients with ERTs, although the PN group showed a higher incidence of high-grade complications than RN, when technically feasible and with experienced surgeons, PN is recommended for better preservation of renal function, longer OS, and similar oncological outcomes.

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Comparison of Radical Nephrectomy and Partial Nephrectomy for T1 Renal Cell Carcinoma: A Meta-Analysis

Cited by 13 publications

References 25 publications

Human immunodeficiency virus-related renal cell carcinoma: a retrospective study of 19 cases

Human immunodeficiency virus-related renal cell carcinoma: a retrospective study of 19 cases

Human Immunodeficiency Virus Related Renal Cell Carcinoma: a Retrospective Study of 19 Cases

Partial Nephrectomy Versus Radical Nephrectomy for Endophytic Renal Tumors: Comparison of Operative, Functional, and Oncological Outcomes by Propensity Score Matching Analysis

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