Efficacy of combined traditional Chinese medicine spray with premature ejaculation desensitization therapy for the treatment of primary premature ejaculation

Cui, Yingdong; Hu, Shu-Bin; Wu, Bo; Li, Shijun; Xiang, Kui; Liao, Zhaolin; Zhang, Huiping; Zhu, Changhong; Rao, Meng

doi:10.4314/ahs.v17i3.2

Cited by 12 publications

(17 citation statements)

References 31 publications

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“…The data extracted from the included studies are summarized in Table 1 based on the type of intervention provided. Proportionately, 31.8% (n = 7) investigated different lifestyle, exercise and/or physical activities [ 58 , 59 , 60 , 61 , 62 , 63 , 64 ]; 22.7% (n = 5) investigated herbal medicine supplements [ 65 , 66 , 67 , 68 , 69 ]; 18.2% (n = 4) investigated topical herbal applications [ 70 , 71 , 72 , 73 ]; 13.6% (n = 3) investigated acupuncture or electroacupuncture [ 74 , 75 , 76 ]; and 4.5% (n = 1) each investigated vitamin, mineral and/or nutraceutical supplements [ 77 ]; hyaluronic acid penile injection [ 78 ]; and music therapy [ 79 ].…”

Section: Resultsmentioning

confidence: 99%

Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review

Leisegang,

Opuwari,

Moichela

et al. 2023

Medicina

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Background and Objectives: Ejaculatory dysfunction (EjD) is a common male sexual disorder that includes premature ejaculation, delayed ejaculation, retrograde ejaculation, and anejaculation. Although psychological and pharmacological treatments are available, traditional, complementary, and alternative medicine (TCAM) is reportedly used. However, the clinical evidence for TCAM in EjD remains unclear. Therefore, this study aims to systematically review human clinical trials investigating the use of TCAM to treat EjD. Materials and Methods: A systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted by searching Scopus and PubMed databases. Controlled clinical trials investigating a cohort of male patients diagnosed primarily with EjD and undergoing any TCAM intervention compared to any comparison group were included. Quality of the studies was assessed using the Cochrane Risk of Bias tool for randomized controlled trials. Results: Following article screening, 22 articles were included. Of these, 21 investigated TCAM in premature ejaculation, and only 1 investigated TCAM in retrograde ejaculation. Different TCAM categories included studies that investigated lifestyle, exercise and/or physical activities (n = 7); herbal medicine supplements (n = 5); topical herbal applications (n = 4); acupuncture or electroacupuncture (n = 3); vitamin, mineral and/or nutraceutical supplements (n = 1); hyaluronic acid penile injection (n = 1); and music therapy (n = 1). Only 31.8% (n = 7) of the included studies were found to have a low risk of bias. The available studies were widely heterogenous in the TCAM intervention investigated and comparison groups used. However, the included studies generally showed improved outcomes intra-group and when compared to placebo. Conclusions: Different TCAM interventions may have an important role particularly in the management of PE. However, more studies using standardized interventions are needed.

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Section: Resultsmentioning

confidence: 99%

Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review

Leisegang,

Opuwari,

Moichela

et al. 2023

Medicina

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“…The therapies for PE have already been extensively studied; however, an increasing number of treatments are emerging, such as yoga, sphincter control training (SCT), acupuncture and masturbation (Cui et al, 2017;Dhikav, Karmarkar, Gupta, & Anand, 2007;Liu et al, 2019;Ma, Zou, Lai, Zhang, & Zhang, 2018;Rodríguez, Marzo, & Piqueras, 2019 First, we analysed the efficacy of the drug for less than 8 weeks of treatment. Topical creams and 9 drugs (SSRI + PDE5i, PDE5i, sertraline, clomipramine, paroxetine, dapoxetine 60 mg, dapoxetine 30 mg, fluoxetine and citalopram) were significantly better than placebo.…”

Section: Discussionmentioning

confidence: 99%

Comparative efficacy and safety of drug treatment for premature ejaculation: A systemic review and Bayesian network meta‐analysis

et al. 2020

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To assess the comparative efficacy and safety of drug treatments for premature ejaculation. A systemic review and Bayesian network meta‐analysis were executed on randomised controlled trials of drug interventions for premature ejaculation. Intravaginal ejaculation latency time and related adverse effects were outcome measures. A total of 44 RCTs with 11,008 patients were included in our NMA. In therapy <8 weeks, the ranking of drug efficacy was topical creams >selective serotonin reuptake inhibitor (SSRI)+ phosphodiesterase 5 inhibitor (PDE5i) > PDE5i > sertraline > clomipramine > paroxetine > dapoxetine 60 milligram (mg) > dapoxetine 30 mg > fluoxetine>citalopram > duloxetine>placebo. In therapy ≥ 8 weeks, the ranking of drug efficacy was SSRI + PDE5i > topical creams > paroxetine > tramadol > PDE5i > fluoxetine > dapoxetine 60 mg > dapoxetine 30 mg > clomipramine>citalopram > placebo. For total adverse events, clomipramine, dapoxetine 30 mg, dapoxetine 60 mg, paroxetine, PDE5i, SSRI + PDE5i and tramadol had a higher risk than placebo. In conclusion, in ≥8 weeks of therapy, the drug combination of SSRI + PDE5i was the most effective PE therapy. In <8 weeks of therapy, the efficacy of local anaesthetics was best. All drug treatments were ranked better than placebo. In general, drugs with better effects had more obvious side effects.

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“…The authors found that traditional Chinese medicine spray (TCMS) was safe and effective for the treatment of premature ejaculation. 1 …”

Section: Sexuality Mother and Child Healthmentioning

confidence: 99%

Editorial: Sexuality, mother-child health and infectious diseases

Tumwine¹

2017

Afr H. Sci.

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Efficacy of combined traditional Chinese medicine spray with premature ejaculation desensitization therapy for the treatment of primary premature ejaculation

Cited by 12 publications

References 31 publications

Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review

Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review

Comparative efficacy and safety of drug treatment for premature ejaculation: A systemic review and Bayesian network meta‐analysis

Editorial: Sexuality, mother-child health and infectious diseases

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