Our data suggest that PPAR-gamma is present in keloid fibroblasts and PPAR-gamma activation inhibits TGF-beta1-induced collagen type I expression at least in part by decreasing collagen synthesis. PPAR-gamma may be a promising therapeutic target for keloids.
An AlGaN layer with good crystalline quality (χmin=2.1%) was grown by metalorganic vapor phase epitaxy on a sapphire (0001) substrate using a GaN intermediate layer. The Al composition, which cannot be unambiguously determined by x-ray diffraction (XRD) or by photoluminescence, was determined by Rutherford backscattering (RBS). The perpendicular and parallel elastic strain of the Al0.28Ga0.72N layer, e⊥=−0.16% and e∥=+0.39%, respectively, were derived using XRD and RBS/channeling. The small ratio |e⊥/e∥|=0.41 indicates that the Al0.28Ga0.72N lattice is much stiffer in the c-axis direction than in the a-axis direction. A comparison of the strain data for GaN, InGaN, and AlGaN layers is presented.
A new non-classical model for first-order shear deformation circular cylindrical thin shells is developed by using a modified couple stress theory and a surface elasticity theory. Through a variational formulation based on Hamilton’s principle, the equations of motion and boundary conditions are simultaneously obtained, and the microstructure and surface energy effects are treated in a unified manner. The newly developed non-classical shell model contains one material length-scale parameter to account for the microstructure effect and three surface elastic constants to capture the surface energy effect. The new model includes shell models considering the microstructure effect only or the surface energy effect alone as special cases and recovers the first-order shear deformation circular cylindrical thin shell model based on classical elasticity as a limiting case. In addition, the current shell model reduces to the non-classical model for Mindlin plates incorporating the microstructure and surface energy effects when the thin shell radius tends to infinity. To illustrate the new model, the static bending and free vibration problems of a simply supported circular cylindrical thin shell are analytically solved. The numerical results reveal that the inclusion of the microstructure and surface energy effects leads to reduced shell deflections and rotation angles and increased natural frequencies. The differences are significant when the shell is very thin, but they diminish as the shell thickness increases. These predicted size effects at the micron scale agree with the general trends observed in experiments.
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