Our data suggest that PPAR-gamma is present in keloid fibroblasts and PPAR-gamma activation inhibits TGF-beta1-induced collagen type I expression at least in part by decreasing collagen synthesis. PPAR-gamma may be a promising therapeutic target for keloids.
Background: Adipose-derived stem cells (ASCs) have shown promise in a vast range of clinical applications, leading to widespread interest and ongoing clinical trials in the areas of soft tissue reconstruction, wound healing, and treatment of ischemic conditions. Despite this, little is known about the effects of donor characteristics on harvested ASCs-factors which may influence patient selection. We hypothesize that variation in BMI could lead to important functional variations in ASCs with meaningful downstream clinical impact.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.