About the Author AbstractPurpose The purpose of this study was to compare the effects of ormeloxifene with medroxyprogesterone acetate in patients with abnormal uterine bleeding. Material and Method 440 Patients were divided into two groups. In group A, ormeloxifene was given at the dosage of 60 mg twice a week for 3 months followed by 60 mg once a week for 1 month. In group B, medroxyprogesterone acetate was given at the dosage of 10 mg twice a day from day 5 to day 25 of the menstrual cycle. At followups, patients were assessed for PBAC score, endometrial thickness by USG, hemoglobin level, and the side effects of drug therapy. Results There were 240 patients in group A and 200 in group B. Reduction in median PBAC score was 79.4 % in group A and 75 % in group B after 4 months of treatment. The mean duration of bleeding reduced to 4.8 from 9 in group A and 5 from 8.7 in group B. Mean hemoglobin was increased from 8.6 to 9.8 g % in group A and from 8.7 to 9.9 g % in group B; endometrial thickness was reduced 123 from 7.7 mm to 6.8 mm in group A and from 7.4 mm to 6.9 mm in group B.Conclusion We conclude from this study that ormeloxifene should be considered the first choice in the management of AUB, especially in the perimenopausal age group where amenorrhea is acceptable.
Objectives: The aim of study is to study the different concentration of intraumblical oxytocin saline injection on duration and blood loss of third stage of labor and other parameter. Methods: After considering inclusion and exclusion criteria, cases were divided in to 5 groups. All Women were injected 50 ml of normal saline into umbilical vein immediately after clamping and cutting the cord, in group A without oxytocin, in Group B with 10 units of oxytocin, in group C with 20 unit oxytocin and in group D with 30 unit oxytocin. In group E (control) women were managed conservatively. Duration and amount of blood loss of third stage was noted. Results: There were total 250 women enrolled in the study. A statistically significant reduction in the duration and amount of blood loss of third stage of labor was found in group B compared to group A. On increasing the concentration of oxytocin from 10 IU to 20 IU a slight reduction in mean duration and amount of blood loss of third stage was noted. On further increasing the concentration of oxytocin to 30 IU a statistical significant reduction was present. Conclusion: For active management of third stage intraumblical injection of oxytocin with saline should be promoted.
Background: Cervical cancer is the leading cause of deaths of women due to malignancies in developing countries worldwide. Having a latency period of upto10 years, preinvasive lesions of cervix give us a wide margin for detection and treatment before it becomes cancerous. This is the aim of this study is to establish a pattern of prevalence of these preinvasive lesions and find out correlation with various epidemiological factors and establish best screening modality in low resource settings like ours. Methods: The cases were studied in terms of their epidemiologic characteristics. The diagnostic accuracy of visual inspection with acetic acid (VIA) and cytology was assessed using colposcopy and biopsy as the gold standard, chisquare test applied and power of the screening test calculated. Results: Abnormal cytology (47/226) was mostly found in age group 30-40 29/47 (61.7%), were para 2 to 4 34/47 (72.3%), belonged to class IV-V socioeconomic class 28(59.6%), belonged to rural areas 32/47(68%) were illiterate 29/47(61.7%) were married at a young age 15-17 23/47(49%) and were not using any contraception 22/47(46.8%). The diagnostic accuracy of the screening tests that is VIA and cytology was tested against the gold standard test which was taken as colposcopy and biopsy in our study. Conclusions: VIA is a screening modality suitable for low resource setting like ours along with cytology. It also offers see and treat option for women in rural areas who are usually lost to follow up.
Gestational Trophoblastic disease is a tumour that is more sensitive and respond well to a wide variety of chemotherapeutic regimes. However emergency hysterectomy is still required for life threatening complications associated with GTD.
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