Role of maternal serum ferritin as a predictive marker in intrauterine growth restriction

Bindal, Neeta; Godha, Zeepee; Kohli, R.; Kadam, V. K.

doi:10.18203/2320-1770.ijrcog20150096

Cited by 5 publications

(15 citation statements)

References 14 publications

(14 reference statements)

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“…This is probably why the current study found a higher degree of correlation between maternal serum ferritin and neonatal birthweight (-0.453) which is higher than those found by Višnjevac et al (-0.24), [15] and Bindal et al (-0.36). [16] On other grounds, Akkurt et al reported a higher hematocrit level in pregnancies with IUGR than controls. [1] They hypothesized that this was related to a degree of hemoconcentration related to IUGR development.…”

Section: Discussionmentioning

confidence: 97%

“…The value of maternal serum ferritin in predicting asymmetric IUGR was previously investigated, for few times, on small numbers of cases, i.e. 7 cases in Ozgu-Erdinc et al [9] , 18 cases in Milasinovic et al [13] , 10 cases in Hubel et al [14] , 17 cases in Visnjevac et al [15] , and 31 cases in Bindal et al, [16] or with limitations in the research methodology such as measuring ferritin at a gestational age that was to early (20 weeks) or to late (36 weeks) [1,4] , or including cases with maternal iron deficiency anemia [15] .…”

Section: Discussionmentioning

confidence: 99%

“…Lower expression of placental transferrin is known to be associated with IUGR [18] . This may cause less iron extraction by the placenta from maternal serum, thus raising the level of serum ferritin [16] . Furthermore, other studies suggest that placental damage, in cases of asymmetric IUGR, releases some of the placental ferritin into the maternal circulation, thus further raising its serum level [1,14,19] .…”

Section: Discussionmentioning

confidence: 99%

“…As opposed to previous studies [3,15,16] , we set anemia among our exclusion criteria. Our results showed non-significant differences between controls and IUGR cases as regards erythrocytic counts, hematocrit and hemoglobin levels, compared to a rate of anemia of 47.4% in the control group of one study [15] .…”

Section: Discussionmentioning

confidence: 99%

“…[13] Its predictive value was previously investigated, in a few small-sized studies, on a small number of cases. [9,[13][14][15][16] This study aimed to assess the accuracy of maternal serum ferritin level at 30 weeks to 32 weeks in predicting the development of IUGR and to identify the ferritin cutoff level with the best predictive value, in a well-selected, adequate-sized group of pregnant women.…”

Section: Introductionmentioning

confidence: 99%

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Role of Maternal Serum Ferritin in the Prediction of Asymmetric Intrauterine Growth Restriction

Salem

Ashoush

Bayoumi

et al. 2019

Evidence Based Women's Health Journal

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Aim: Asymmetric intrauterine growth restriction (IUGR) carries increased intrauterine and neonatal risks. Since most cases are idiopathic, identifying a predictive test remains an ideal prevention management. Maternal serum ferritin level is a potential predictor of later developing asymmetric IUGR. Patients and Methods: Blood samples were drawn, at 30-32 gestational weeks, from 450 women who were then followedup resulting in 32 term pregnancies with asymmetric IUGR. The control group included the first recruited 32 women delivering adequate for gestational age neonates at term. Serum ferritin was then measured in the stored serum samples. Ultrasound scanning was performed at 30-32 weeks then at 37 weeks. Umbilical and middle cerebral artery Doppler scans were added at 37 weeks. Results: Serum ferritin, at 30-32 weeks, was higher in women delivering IUGR babies (19.3±6.83 vs 14±5.18, p<0.01). At 37 weeks, pregnancies with asymmetric IUGR had significantly (p<0.01) higher umbilical artery resistance and pulsatility indices (0.71±0.06 vs 0.59±0.07 and 1.24±0.17 vs 0.86±0.09, respectively). Their middle cerebral artery RI and PI were significantly (p<0.01) lower than controls (0.74±0.09 vs 0.81±0.05 and 1.64±0.07 vs 1.9±0.15, respectively). Ferritin level correlated significantly with neonatal birthweight. A cutoff level >18.2 ng/mL had a sensitivity of 59.4% and a specificity of 90.6%. The area under curve showed an accuracy of 76.8%. Women with ferritin >18.2 ng/ml were 10.23 times more likely to get asymmetrically growth restricted neonates (CI 2.89-36.17, p<0.001). Conclusion: This study presents further evidence that maternal serum ferritin may be a useful test in the prediction of asymmetric IUGR.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Role of Maternal Serum Ferritin in the Prediction of Asymmetric Intrauterine Growth Restriction

Salem

Ashoush

Bayoumi

et al. 2019

Evidence Based Women's Health Journal

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Serum zinc, selenium, iron, and copper levels in pregnant women with fetal growth restriction

Wibowo¹,

Irwinda²,

Rivai³

2019

Clin. Exp. Obstet. Gynecol.

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Background: Fetal growth restriction is associated with many adverse effects and increases the risk of perinatal mortality by more than ten-fold. Zinc, selenium, iron, and copper have important roles in cell proliferation, inflammation, and oxidative stress which possibly serve as the basis for development of fetal growth restriction. Objective: To compare serum zinc, selenium, iron, and copper plasma levels between normal pregnancies and pregnancies with fetal growth restriction. Materials and Methods: The present was a cross-sectional study conducted at Obstetrics Emergency Unit of Cipto Mangunkusumo Hospital Jakarta from February until May 2017. Normal pregnant women and pregnant women with fetal growth restriction were recruited in this study. Maternal blood samples were taken before labor, and serum zinc, selenium, iron, and copper levels measurements were done. Results: Thirty normal pregnancies and 30 pregnancies with fetal growth restriction were enrolled in this study. Mean serum zinc, selenium, iron, and copper levels in normal pregnancy were 42.07 µg/dL, 69.80 µg/L, 70.50 µg/dL, and 2177 µg/L, respectively. Meanwhile, mean serum zinc, selenium, iron, and copper levels in pregnancy with fetal growth restriction were 43.53 µg/dL, 80.83 µg/L, 106 µg/dL, and 2,133.5 µg/L, respectively. There were significant differences in serum selenium concentrations (p = 0.013) and serum iron concentrations (p = 0.009) between the two groups. There were no significant differences in serum zinc and copper levels between both groups. Conclusion: Serum selenium and iron levels were higher in pregnancies with fetal growth restriction. Conclusion: The present study indicates the significant roles of micronutrients and oxidative stress in the pathophysiology of fetal growth restriction.

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Study of Role of Maternal Serum Ferritin in the Prediction of Asymmetric Intrauterine Growth Restriction

Elfayomy¹,

Abdelsalam²,

Mohamed³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Late-onset asymmetric Intrauterine Growth Restriction (IUGR) is associated with an increase in the maternal serum ferritin level, which is thought to be caused by a decrease in placental extraction ferritin from the systemic circulation. Objective: The aim of the current study was to predict asymmetric IUGR by measuring maternal serum ferritin at 30-32 weeks of gestation. Patients and methods: A cross sectional study was conducted on a total of 550 women. At 30-32 weeks of gestation, maternal serum ferritins were assessed. Of the studied women, 84 women were selected and divided into two groups; 42 cases of elevated serum ferritin level taken as a case group and the first included 42 cases with normal serum ferritin level served as a control group. At 30-32 weeks of gestation, we assessed maternal serum ferritin. Results: Serum ferritin is good marker for detecting cases of IUGR at cut off ≥12.45 with a sensitivity of 85.7%, a specificity of 35.7%, a positive predictive value of 57.1% and a negative predictive value of 71.4%., while serum ferritin is good marker for excluding cases of IUGR at cut off ≥20.5 with a sensitivity of 33.3%, a specificity of 85.7%, a positive predictive value of 70% and a negative predictive value of 56.3%. Conclusion: Serum ferritin level with a cut off level ≥12.45 ng/dl in addition to ultrasonography has as a predictive value of asymmetric IUGR

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Role of maternal serum ferritin as a predictive marker in intrauterine growth restriction

Cited by 5 publications

References 14 publications

Role of Maternal Serum Ferritin in the Prediction of Asymmetric Intrauterine Growth Restriction

Role of Maternal Serum Ferritin in the Prediction of Asymmetric Intrauterine Growth Restriction

Serum zinc, selenium, iron, and copper levels in pregnant women with fetal growth restriction

Study of Role of Maternal Serum Ferritin in the Prediction of Asymmetric Intrauterine Growth Restriction

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