We determined that premedication with atropine suppressed the incidence and severity of fentanyl-induced cough during induction of general anesthesia. We think that, due to its antimuscarinic effect, atropine is as effective as lidocaine as a premedication.

Objective:Fentanyl is frequently used during anesthesia induction. The use of fentanyl can cause cough through different mechanisms. Here, we aimed to investigate effects of pheniramine maleate (PM), an antihistaminic agent, and compare it with lidocaine on fentanyl induced cough.Methods:This is a randomized double-blind prospective clinical study of ASA I-II, 120 patients scheduled for elective abdominal surgery. Patients were administered drugs intravenously and randomly allocated into three groups: Group C (2 ml 0.9 % normal saline), Group L (1mg/kg lidocaine), and Group F (PM 45.5 mg). 90 seconds after administration, 2µ/kg fentanyl was applied in three seconds to all patients. Severity of cough (mild: 1-2, moderate: 3-5, severe> 5), time of the cough and vital parameters were recorded 90 seconds after fentanyl injection.Results:Eight patients (25%) in Group C had fentanyl induced cough whereas three patients (7.5%) in Group L and one patient (2.5%) in Group F experienced this phenomenon. There was statistically significant difference between Group F and Group C (p<0.05); however, differences between Group L and Group C or Group F and Group L were not statistically significant (p>0.05).Conclusions:Pheniramine Maleate 45.5 mg is better that placebo and as effective as lidocaine to prevent fentanyl induced cough.

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GİRİŞAnne ve bebek sağlığı için sezaryen ameliyatlarında tercih edilecek anestezi yöntemi çok önemlidir 1,2 . Bu ameliyatlarda uygulanacak anestezi yönetimi; cerrahinin aciliyeti, hastanın klinik durumu, anestezi uzmanının deneyimi ve hasta tercihine göre seçilme-lidir. Sezaryen operasyonlarında genel anestezi (GA) ve rejyonal (bölgesel) anestezi (RA) [kombine spinalepidural (KSEA), epidural anestezi (EA), spinal anestezi (SA)] yöntemleri uygulanmaktadır.GA'nin hava yolu kontrolü sağlaması, acil durumlarda hızlı indüksiyon, daha az hipotansiyon ve daha iyi ABSTRAcT