The effects of dexamethasone vs low doses of propofol infusion on postoperative nausea and vomiting in tympanoplasty surgery: a randomized, placebo-controlled, double-blinded study

Özmen, Özgür; Bingöl, Fatih; Arslan, Zakir; Bingöl, Buket Özel

doi:10.5222/mmj.2017.085

Cited by 2 publications

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“…The antiemetic effect of propofol is attributed to modulation of subcortical pathways to inhibit nausea or its direct depressant action on the vomiting center [ 29 ]. The results of our study are consistent with other studies, conducted in different settings, in terms of antiemetic rescue therapy requirements and trends of dexamethasone preventive effect [ 22 , 23 , 25 , 30 , 31 ].…”

Section: Discussionsupporting

confidence: 92%

“…Propofol, an antagonist at the 5-HT3 receptor, is also a novel total intravenous anaesthetic that possesses antiemetic properties when given in subhypnotic doses as part of combination therapy [ 5 , 20 ]. Low-dose intravenous propofol (0.5 mg/kg) is effective for prevention of PONV with no significant complications [ 4 , 21 , 22 ]. Even though propofol has been used by a number of anesthesiologists, it is still under investigation.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Propofol versus Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Ear, Nose, and Throat Surgery in Tikur Anbessa Specialized Hospital and Yekatit 12th Hospital, Addis Ababa, Ethiopia

Bantie

Admasu

Mulugeta

et al. 2020

Anesthesiology Research and Practice

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Background. Postoperative nausea and vomiting (PONV) remain as common and unpleasant and highly distressful experience following ear, nose, and throat surgery. During ENT surgery, the incidence of PONV could be significantly reduced in patients who receive dexamethasone and propofol as prophylaxis. However, the comparative effectiveness of the two drugs has not been assessed. The aim of this study was to compare the effectiveness of propofol and dexamethasone for prevention of PONV in ear, nose, and throat surgery. Methods. This study was conducted in 80 patients, with ASA I and II, aged 18–65 years, and scheduled for ENT surgery between December 20, 2017, and March 20, 2018. Patients were randomly assigned to Group A and Group B. Immediately after the procedure, Group A patients received single dose of intravenous (IV) dexamethasone (10 mg/kg) and Group B patients were given propofol (0.5 mg/kg, IV), and equal follow-up was employed. The incidence of PONV was noted at 6th, 12th, and 24th hour of drug administration. Independent t-test and Mann–Whitney test were used for comparison of symmetric numerical and asymmetric data between groups, respectively. Categorical data were analyzed with the chi-square test, and p value of < 0.05 was considered as level of significance. Results. The incidences of PONV throughout the 24-hour postoperative period were 35% in the propofol group and 25% in the dexamethasone group. Statistical significance was found in incidence of PONV (0% versus 22.5%) and use of antiemetic (0% versus 5%) between dexamethasone and propofol groups, respectively, at 12–24 hours. Over 24 hours, 5% in dexamethasone group and 12.5% in propofol group developed moderate PONV, while none of the participants felt severe PONV. Conclusions. Dexamethasone was more effective than propofol to prevent PONV with lower requirements of rescue antiemetics.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effectiveness of Propofol versus Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Ear, Nose, and Throat Surgery in Tikur Anbessa Specialized Hospital and Yekatit 12th Hospital, Addis Ababa, Ethiopia

Bantie

Admasu

Mulugeta

et al. 2020

Anesthesiology Research and Practice

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“…Preventing PONV with low-dose intravenous propofol (0.5 mg/kg) is efficacious and has no major side effects. There are many anesthesiologists who have utilized propofol, although it is still being studied 12,13 . For intravenous anaesthesia, propofol is now the drug of choice.…”

Section: Introductionmentioning

confidence: 99%

Propofol's Effectiveness in Preventing Nausea and Vomiting Following ENT Procedures Performed Under General Anesthesia

Sifatullah¹,

Babar²,

Haq³

et al. 2022

PJMHS

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Objective: Evaluation of Propofol's effectiveness in preventing post-surgery nausea and vomiting after ENT operations performed under general anesthesia Study design: Observational study Sampling method: lottery system Study Place: Peshawar Methods: 70 patients between age 18-65, having elective ENT surgery under conventional general anesthesia were included in this observational. After the surgical procedure, the patients were given either 10 mg/kg of dexamethasone, or 0.5 mg/kg of propofol intravenously. For 24 hours after surgery, the patients were monitored for any instances of nausea and vomiting. Results: No significant variation in Mean ± S.D of age, gender, BMI, ASA categorization and type of surgery was observed in both dexamethasone and propofol group. A significant variation in surgery duration (p=0.031) and anesthesia time (0.001) was observed in both the groups. PONV was more common in the propofol group (70%) than in the dexamethasone group (40%), particularly in the first six hours after surgery. Practical implication: this study will help to determine the whether propofol is a better choice for preventing post-operative nausea and vomiting. Conclusion: Propofol was less efficient than dexamethasone in preventing PONV, necessitating less rescue antiemetic use. Keywords: ENT, Propofol, nausea, vomiting, post-surgery complication, dexamethasone, effectiveness

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The effects of dexamethasone vs low doses of propofol infusion on postoperative nausea and vomiting in tympanoplasty surgery: a randomized, placebo-controlled, double-blinded study

Cited by 2 publications

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Effectiveness of Propofol versus Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Ear, Nose, and Throat Surgery in Tikur Anbessa Specialized Hospital and Yekatit 12th Hospital, Addis Ababa, Ethiopia

Effectiveness of Propofol versus Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Ear, Nose, and Throat Surgery in Tikur Anbessa Specialized Hospital and Yekatit 12th Hospital, Addis Ababa, Ethiopia

Propofol's Effectiveness in Preventing Nausea and Vomiting Following ENT Procedures Performed Under General Anesthesia

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