Effects of a single-dose preemptive pregabalin on acute and chronic pain after inguinal hernia repair with mesh under spinal anaesthesia

Ahıskalıoğlu, Elif Oral; Ahişkalıoğlu, Ali; Aydin, Pelin; Arslan, Zakir; Aksoy, Mehmet; Temiz, Ayetullah

doi:10.1097/eja.0000000000000395

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…Bupivacaine, lidocaine, clonidine, ketorolac, oral ibuprofen, gabapentin, and pregabalin are drugs used for this purpose. [ 13 – 15 ] The number of studies of IV ibuprofen use is still limited.…”

Section: Discussionmentioning

confidence: 99%

Effects of single-dose preemptive intravenous ibuprofen on postoperative opioid consumption and acute pain after laparoscopic cholecystectomy

et al. 2017

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Background:Although studies involving intravenous (IV) ibuprofen are still limited, it has been shown to have a potential role in the treatment of postoperative pain. The primary objective of this study was to investigate the effects of preemptive IV ibuprofen on postoperative 24 hour opioid consumption and postoperative pain in patients undergoing laparoscopic cholecystectomy.Methods:Following ethical committee approval, 60 patients aged 18 to 65, American Society of Anesthesiology (ASA) I–II, and scheduled for laparoscopic cholecystectomy were included in this prospective, randomized, double-blinded study. Patients were randomly divided into 1 of 2 groups. The control group (n = 30) received 100 mL saline solution 30 minutes before surgery, while the ibuprofen group (n = 30) received 400 mg IV ibuprofen in 100 mL saline. The same general anesthesia protocol was applied in both groups, and all operations were performed by the same surgeon using the same technique. Postoperative analgesia was assessed using a visual analogue pain scale (VAS) with active and passive movements. Twenty-four hour postoperative fentanyl consumption with patient-controlled analgesia and additional analgesia requirements were recorded. Postoperative analgesia was established with 1000 mg paracetamol once every 6 hours and patient-controlled IV fentanyl.Results:Compared with the control group, VAS scores in the IV ibuprofen group were statistically lower at postoperative 30 minutes and 1, 2, 4, 8, 12, and 24 hours (P < 0.001). Twenty-four hour opioid consumption was statistically significantly higher in the control group compared to the ibuprofen group (553.00 ± 257.04 and 303.33 ± 132.08 μcq, respectively, P < 0.001). Additional analgesia use was statistically significantly higher in the control group than in the ibuprofen group (14/30 vs 5/30, respectively, P < 0.001). The rates of nausea and vomiting were higher in group control than in group ibuprofen (13/30 vs 5/30, respectively, P = 0.024). Other side-effects were similar between the groups.Conclusion:A preemptive single dose of IV ibuprofen in laparoscopic cholecystectomy reduced postoperative opioid consumption in the 1st 24 hours by 45%. It generated lower pain scores in the postoperative period compared with placebo.

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Section: Discussionmentioning

confidence: 99%

Effects of single-dose preemptive intravenous ibuprofen on postoperative opioid consumption and acute pain after laparoscopic cholecystectomy

et al. 2017

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“…On the other hand, tourniquet use during limb surgery involving occlusion of the blood ow and the subsequent restoration of perfusion, which may result in ischemia-reperfusion injury (IRI) [9]. This process inevitably initiates the generation of reactive oxygen species (ROS) and triggers oxidative reaction, and in turn results in the production of macromolecules, such as hydrochloric acid, malonyldialdehyde (MDA) and ischaemia-modi ed albumin (IMA), thus leading to cellular necrosis and apoptosis and hence organ dysfunction [10][11]. Although skeletal muscle is relatively resistant to IRI when compared to other organs, it has been reported that irreversible damage will occur after a long time of complete ischemia, such as muscular dysfunction and tissue necrosis [9,11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Tourniquet Use in Ankle Arthroscopic Surgery on Postoperative Recovery: A Prospective Non- Randomized Controlled Study

Huang

Liu

et al. 2020

Preprint

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The aim of this prospective non- randomized controlled study was to explore the effect of tourniquet use on joint swelling, pain, functional outcome, and tourniquet- related ischemia- reperfusion injury (IRI) during ankle arthroscopic surgery.52 patients who received ankle arthroscopy were allocated to had the procedure done with the tourniquet inflated (the Control group, n= 27) or without the tourniquet inflated (the NT group, n= 25). The main outcome measures were: (1) The amount of swelling of the ankle; (2) Pain as measured by a visual analog scale (VAS); (3) The levels of MDA, IMA,TOS, TAS and OSI at 10 min before incision (T1)，after the completion of surgery (T2), and 30 min after tourniquet deflation (T3); (4) The functional outcome as measured by American Orthopaedic Foot and Ankle Society (AOFAS) ankle hindfoot score; (5) The rate of complication. All patients were reviewed at a mean follow- up of 14.2 months (range, 12- 19 months). The mean circumferences of the ankle in the NT group were significantly lower than those in the Control group on postoperative day 2 and 5 (p<0.05). The mean level of VAS in the Control group was significantly higher on postoperative day 2 (p<0.05). The outcomes of AOFAS ankle hindfoot score were comparable between groups postoperatively (p>0.05). The levels of MDA, IMA, TOS and OSI were all significantly lower in the NT group compared at T2 and T3 (p<0.05), and the level of TAS was significantly lower in the NT group at T3 (p<0.05). The complication rates of two groups were comparable (p>0.05).With the use of tourniquet during ankle arthroscopic surgery, there was increased joint swelling and pain postoperatively, and a trend toward increased levels of MDA, IMA, TOS, TAS and OSI intraoperatively. Thus, we do not recommend using a tourniquet in this type of procedure.

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“…However, the mechanism of the action of pregabalin is not yet completely understood, and it is currently indicated for the treatment of diabetic neuropathy, fibromyalgia, and anxiety. Recently, it was found to be effective against postoperative pain [4,9,10]. Additionally, some experimental studies have demonstrated that pregabalin has neuroprotective, antiinflammatory, and apoptosis-reducing effects, and it was effective for improving myelin production, cerebral ischemia, and reperfusion injury [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The effect of pregabalin on the tourniquet induced ischemia-reperfusion injury. A Prospective Randomized Study

Karaca¹,

Pınar²,

Ozgur³

et al. 2019

Turk J Med Sci

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The aim of this study was to investigate the efficacy of pregabalin on ischemia-reperfusion injuries. Materials and methods: Fifty-four patients were randomly assigned into 2 groups. A 150-mg tablet of pregabalin was given the night before and then 1 h before the operation for patients in Group P (pregabalin group, n = 27). A placebo was given to patients in Group C (control group, n = 27) at the same times. After combined spinal-epidural anesthesia was performed, venous blood samples were taken before tourniquet inflation (t 1), just before tourniquet deflation (t 2), and 20 min after tourniquet deflation (t 3) for the analysis of total antioxidant status (TAS), total oxidant status (TOS), catalase (CAT), and ischemia-modified albumin (IMA). Results: There was no significant difference in TAS levels between the groups for the t 3 period. However, the TAS in Group P was significantly higher in the t 3 period than the t 2 period (mean ± SD, 0.46 ± 0.1 vs. 0.38 ± 0.2 mmol of Trolox equivalent/L, respectively; P < 0.05). The CAT level in the t 3 period was significantly higher in Group P than Group C (mean ± SD, 53.04 ± 32.1 vs. 35.46 ± 17.2 µmol/ formaldehyde, respectively; P < 0.05). In the t 3 period, the TOS was significantly lower in Group P than Group C (mean ± SD, 11.97 ± 5 vs. 18.29 ± 9.9 pg/mL, respectively; P < 0.05). The TOS in Group P was significantly lower in the t 3 period than the t 2 period (mean ± SD, 11.97 ± 5 vs. 18.98 ± 10.7 pg/mL, respectively; P < 0.0001). Conclusion: Pregabalin has no marked antioxidant activity, but it contributes to the antioxidant defense system of an organism.

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Effects of a single-dose preemptive pregabalin on acute and chronic pain after inguinal hernia repair with mesh under spinal anaesthesia

Cited by 6 publications

References 7 publications

Effects of single-dose preemptive intravenous ibuprofen on postoperative opioid consumption and acute pain after laparoscopic cholecystectomy

Effects of single-dose preemptive intravenous ibuprofen on postoperative opioid consumption and acute pain after laparoscopic cholecystectomy

Effect of Tourniquet Use in Ankle Arthroscopic Surgery on Postoperative Recovery: A Prospective Non- Randomized Controlled Study

The effect of pregabalin on the tourniquet induced ischemia-reperfusion injury. A Prospective Randomized Study

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