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Summary: In a study of 210 patients with corneal ulcer, 105 were clinically diagnosed as mycotic keratitis. 25 of these were positive for fungi in culture. Only 6 of the remaining, 105 cases of keratitis, were of fungal origin. Species of Aspergillus were dominant (11) followed by those of Fusarium and Candida (5 each). Out of 31 fungus positive cases 26 had mycelial fungi and 5 Candida spp. Amphotericin B plus nystatin (mycostatin) or amphotericin B alone were most effective for the former and latter fungal infections respectively. Zusammenfassung: Bei 210 Patienten mit Homhautgeschwüren wurde 105mal klinisch die Diagnose einer mykotischen Keratitis gestellt. In 25 Fällen konnte dabei ein Pilz kulturell nachgewiesen werden. Von den übrigen Fällen erwiesen sich nur 6 als durch Pilze verursacht. Bei den isolierten Pilzen handelte es sich vor allem um Aspergillus‐Arten (11). Fusarium‐ und Candida‐Arten kamen in je 5 Fällen vor. Bei den insgesamt 31 Fällen mit Pilznachwels fanden sich 26mal Hyphomyzeten und 5mal Candida‐Arten. Amphotericin B in Kombination mit Nystatin oder Amphotericin B allein waren bei diesen Infektionen am besten wirksam.

Glechoma hederacea var. longituba (common name: ground-ivy) has been used for the treatment of asthma, bronchitis, cholelithiasis, colds, and inflammation. In the present study, three new sesquiterpene glycosides (1–3), two new diterpene glycosides (4–5), and four known compounds (6–9) were isolated from its MeOH extract. Structure elucidation was performed for the five new compounds (1–5) using 1D and 2D NMR, HRESIMS, ECD calculation, and chemical methods. All the isolates (1–9) were assessed for their anti-neuroinflammatory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, nerve growth factor (NGF) secretion stimulation activity in C6 glioma cells, and cytotoxic activity against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15). Compounds 2 and 5–7 exhibited inhibitory effects on NO production with IC50 values of 52.21, 47.90, 61.61, and 25.35 μM, respectively. Compound 5 also exhibited a significant stimulating effect on NGF secretion (122.77 ± 8.10%). Compound 9 showed potent cytotoxic activity against SK-OV-3 (IC50 3.76 μM) and SK-MEL-2 (IC50 1.48 μM) cell lines, while 7 displayed a strong cytotoxic activity against SK-MEL-2 (IC50 9.81 μM) cell line