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BackgroundAlthough physical activity is known to be beneficial to lung function, few studies have been conducted to investigate the correlation between physical activity and lung function in dusty areas. Therefore, the purpose of this study is to investigate the correlation between physical activity and lung function in a Korean cohort including normal and COPD-diagnosed participants.MethodsData obtained from the COPD in dusty areas (CODA) cohort was analyzed for the following factors: lung function, symptoms, and information about physical activity. Information on physical activity was valuated using questionnaires, and participants were categorized into two groups: active and inactive. The evaluation of the mean lung function, modified Medical Research Council dyspnea grade scores, and COPD assessment test scores was done based on the participant physical activity using a general linear model after adjusting for age, sex, smoking status, pack-years, height, and weight. In addition, a stratification analysis was performed based on the smoking status and COPD.ResultsPhysical activity had a correlation with high forced expiratory volume in 1 second (FEV1) among CODA cohort (p=0.03). While the active group exhibited significantly higher FEV1 compared to one exhibited by the inactive group among past smokers (p=0.02), no such correlation existed among current smokers. There was no significant difference observed in lung function after it was stratified by COPD.ConclusionThis study established a positive correlation between regular physical activity in dusty areas and lung function in participants.

cused cognitive behavioral therapy, cognitive processing therapy (CPT), and prolonged exposure therapy (PE). These are strongly recommended first-line therapies in major PTSD treatment guidelines. 9 Recently, Sloan and Marx' s 10 research team introduced a fivesession exposure-based PTSD treatment protocol called written exposure therapy (WET). WET is recommended for the treatment of PTSD in clinical practice guidelines (Department of Veterans Affairs/Department of Defense, 2017). Like other EBTs, it comprises critical components considered to be responsible for the successful treatment of PTSD symptoms, such as therapeutic exposure and cognitive processing/cognitive restructuring. [10][11][12] However, WET requires a smaller number of sessions, shorter session durations, and no between-session assignments. 10,13 The efficacy of WET was evaluated using a randomized controlled trial, and this study reported a significant reduction in PTSD symptom severity at the post-treatment follow-up, and symptom reduction was maintained three and six months later with 7% of drop-out rate. 14 A study that directly compared WET

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Poor survival of human pluripotent stem cells (hPSCs) following freezing, thawing, or passaging hinders maintenance and differentiation in stem cell research. Rho-associated kinases (ROCKs) play a crucial role in hPSC survival. To date, a typical ROCK inhibitor, Y-27632, has been the primary agent used in hPSC research. Here, we report that another ROCK inhibitor, fasudil, can be used as an alternative. Fasudil increased hPSC growth due to survival rather than proliferation following thawing and passaging, similar to Y-27632. It did not affect pluripotency and genetic integrity including mitochondrial genome (mtDNA). Notably, the genes related to metabolism, mTORC1, and TP53 have mainly displayed a faster recovery pattern with ROCK inhibitors than control. Furthermore, fasudil was confirmed as useful for the single dissociation of hPSCs and for aggregation. It also increased retinal pigment epithelium (RPE) differentiation and the survival of neural crest cells during differentiation. These findings suggest that fasudil can replace Y-27632 for use in stem cell research.

A seemingly rational workplace, in fact, is full of intertwined emotional events, and grief is one of them. However, the significance of underlying emotions that employees carry with them to the workplace and the impact of employees’ perceived notions toward the organization about the way management handles employee problems are not recognized and properly understood. I learned about my own emotional struggles and those of my coworkers while experiencing the loss of a close colleague, Jay, with cancer. This autoethnographical study is my attempt to formulate a narrative of the whole experience to elicit subjective meanings and learning from it.

Despite the success of tobacco control efforts in reducing smoking rates during the past 50 years, data on the factors contributing to quitting success are still lacking. Smoking-related mortality among women has also not declined. Therefore, this study aimed to characterize sociodemographic features, smoking-related behaviors, mental illness, and smoking cessation in woman smokers in Korea who were registered in the Quitline program. Furthermore, factors associated with 30-day and 1-year successful smoking cessation after enrollment in the Quitline program were investigated. A total of 3360 adult woman Quitline users from 2007 to 2018 were included in the final analysis, with information on their age, education level, marital status, body mass index, frequency of alcohol consumption per month, nicotine dependency, self-efficacy for smoking cessation, presence of a smoking cessation supporter, and mental health history collected upon registration with the Quitline program in Korea. Their cessation outcome was investigated with a 1-year follow-up until the end of 2019. A multiple logistic regression analysis was conducted to identify factors associated with smoking cessation at the 30-day and 1-year follow-ups. The results of the multiple logistic regression analysis indicated that lower nicotine dependency, higher self-efficacy, and the presence of a smoking cessation supporter improved the odds of smoking cessation at the 30-day and 1-year follow-ups. In contrast, users with a mental health condition were less likely to achieve smoking cessation. Incorporating methods to increase self-efficacy in women who decide to quit smoking will contribute to facilitating more attempts to quit and achieving greater success in smoking cessation among woman smokers.